Department of Biomedicine

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Jeppe Prætorius

Professor

Publications

Profile photoJeppe Praetorius
Professor MSO
Department of Biomedicine - Forskning og uddannelse, Syd
Wilhelm Meyers Allé 3, 1233, 219
8000, Aarhus C
Denmark
E-mail: jp@ana.au.dk
Phone: 87167636
Born August 4th 1965, Glostrup, Denmark

Education and postgraduate positions

2010-Professor MSO in epithelial cell biology, Department of Biomedicine, Aarhus University (AU)
2009Aquired title of dr.med. (DMSc), AU
2005-9Associate professor, Institute of Anatomy, AU
2002-5Assistant professor, Institute of Anatomy, AU
2000-2Visiting Fellow (postdoc), Section for Transport Physiology, LKEM, NIH, Bethesda, MD, USA
2000Aquired PhD degree, University of Southern Denmark - Odense (SDU)
1996-99PhD stipendiate, Institute for Medical Biology, SDU
1995-6Internships, military duty
1994Graduated from medical school, Odense University (OU)
1992Diploma in Medical Research, Department of Pharmacology, OU

International meetings

2013Experimental Biology (FASEB), Boston, MA, USA45. Meeting on Membrane Transport, Sandbjerg Gods, AU
2012Experimental Biology (FASEB), San Diego, CA, USA Society for Experimental Biology, Annual Main Meeting, Salzburg, AT 4. Meeting on Molecular Approaches to Membrane Transport, Scand Phys Soc, Sigtuna, SE
2011 Experimental Biology (FASEB), Washington, DC, USA Annual Meeting of the Scandinavian Physiological Society, Bergen, NO International Bicarbonate Transport Meeting, AU 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels: Molecular Mechanisms and Pathophysiology, Pacific Grove, CA, USA
2010Joint Meeting of the Scandinavian and German Physiological Societies, University of Copenhagen (KU), DK 53rd Annual Meeting of the Canadian Society for Biochemistry, Molecular and Cellular Biology, Banff, Alberta, CA Experimental Biology (FASEB), Anaheim, CA, USA
2009Experimental Biology (FASEB), New Orleans, LA, USA Letten Research Centre Opening and WIRED meeting, University of Oslo, NO ISN Forefronts Symposium on Renal and Extrarenal Control of Acid-base Homeostasis in Health Disease, Firenze, IT 5th Borrelli Conference Acid-base and electrolyte balance: from bench to clinic, Napoli, IT TRP Channels: From Sensory Signaling to Human Disease, Karolinska Institutet, Stockholm, SE
2008 Experimental Biology (FASEB), San Francisco, CA, USA 40. Meeting on Membrane Transport, Sandbjerg Gods, AU 1st international Meeting on Brain Aquaporins, Oslo, NO
2007World Congress of Nephrology (ICN), Rio de Janeiro, Brazil 6th International Symposium on Aldosterone and ENaC: from gene to disease. Zermatt, CH
2006Experimental Biology (FASEB), San Francisco, CA, USA Focused Meeting on Frontiers in Epithelial Transport (Fysoc), Manchester, UK 3rd Key Symposium: Membrane transport proteins in health and disease (R Sw Acad Sci), Stockholm, Sverige 38. Meeting on Membrane Transport, Sandbjerg Gods, AU
2005Experimental Biology (FASEB), San Diego, CA, USA 37.th Meeting on membrane Transport, Sandbjerg Gods, AU
2004Experimental Biology (FASEB), Washington DC, USA
2003PhysPharm (Nordisk Fysiologisk Forening), SDU NorFa workshop on water transport and volume regulation, Gålå, Norge
2002Renal Week (American Society of Nephrology), Philadelphia, PA, USA
2001Experimental Biology (FASEB), Orlando, Florida, USA
1999Molecular Physiology of Chloride Channels & Acid/Base Transporters in Epithelial Cells, The British Physiological Society, Manchester, England
199810th International Conference on Second Messengers and Phosphoproteins, Jerusalem, Israel 31. Meeting on Membrane Transport, Sandbjerg Gods, AU
1996Fall meeting. Nordic Physiological Society, Helsinki University, Finland
1992XX Nordic Congress of Physiology & Pharmacology, KU
199124. Meeting on membrane Transport, Sandbjerg Gods, AU

Invited speaker

2013Department of Pathology, Harvard Medical School - Boston Children's Hospital Boston, MA, USA Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA
2012Society for Experimental Biology, Annual Main Meeting, Salzburg, AU 4. meeting on Molecular Approaches to Membrane Transport, Scand Phys Soc, Sigtuna, SE
2011Annual Meeting of the Scandinavian Physiological Society, Bergen, NO International Sapere Aude Bicarbonate Transport Meeting, AU
2010Annual Meeting of the Scandinavian Physiological Society, Kbh, DK 53rd Annual Mtg. & Conference Can Soc Biochem Mol Cell Biol, Banff, Canada Dept of Physiol Biophys, Case Western Reserve University, Cleveland, OH, USA
2009L'Institut de Pharmacologie de l'Université de Lausanne, Suisse Danish Spring Meeting on Transgenic Mouse Research, Biocenter, Kbh's Universitet Letten Research Centre Opening and WIRED meeting, Oslo, NO 5th Borrelli Conference Acid-base and electrolyte balance: from bench to clinic, Napoli, IT
20081st international Meeting on Brain Aquaporins, Oslo, NO
2006 Focused Meeting on Frontiers in Epithelial Transport (Fysoc), Manchester, UK Fysiologi & Farmakologi , Syddansk Universitet Fysiologisk Institut, Aarhus Universitet
2005Experimental Biology 2005, San Diego, CA, USA
2004Department of Pharmacology, University of Cambridge, England
2003Fysiologisk Institut, Aarhus Universitet
2001Vand og Salt Centeret, Aarhus Universitet Fysiologi & Farmakologi , Syddansk Universitet
2000NHLBI, National Institutes of Health, Bethesda, MD, USA
1999Fysiologi & Farmakologi, Syddansk Universitet Medicinsk Gastroenterologisk Afd., Odense Universitetshospital
1998Afd. for Farmakologi, Odense Universitet
1991Danish Society for Pharmacology, Pharm. Inst., University of Copenhagen

Teaching

More than 1200 lectures and practicals in Cell biology and Histology for medical and molecular medicine students, AU
Performed more than 750 oral examinations in Cell biology and Histology, AU
Censored more than 750 students in written exams, SDU Module 6 (Gastointestinal anatomy, histology, physiology, biochemistry and nutrition) and SDU Module 4 (Skeletal system anatomy, histology, muscle physiology/biochemistry and occupational medicine)
Lectures in Pharmacology for medical and biomedical students, SDU
Taught microscopy, antibody-techniques, structure-function analysis of membrane proteins, and renal physiology at PhD courses and summer schools, AU

Scientific supervision and censorship

Main supervisor for PhD students Helle H Damkier, Marlene V Hofmeister, Janne Lebeck, Muhammad Umar Cheema, Henriette Lajgaard Christensen, and Inga Baash Christensen.
Co-supervisor for PhD students Jacob Nielsen, Hanne B Møller, Ebbe Bødtkier, Anna Mroviec, Elena V Bouzinova, Sabina Jelen, Lena Lindtoft Rosenbæk, Søren Poulsen, Anders Dæhli Skjolding.
Main supervisor for medical research year students Helle H Damkier, Thomas Buus Jensen, Søren Olesen
Co-supervisor for medical research year students Uffe Kjær Schou, Christian Daugaard Peters, Janne Lebeck, An Tuyet Nguyen.
Censor of 2 PhD defences (KU and Cambridge University, UK), 4 Medical research year defences (2 AU, 3 SDU), 3 Masters defences (KU and AU), >15 Bachelor theses (AU, SDU, KU).
Heading 5 PhD evaluation committes (AU).

Society memberships

2012-American Society of Nephrology
2011-Danish Hypertension Society Danish Heart Association
2010-Danish Biochemical Society
1999-Scandinavian Physiological Society American Physiological Society
1994-Danish Medical Society

Other academic and administrative work

Reviewer for: Comprehensive Physiology; Physiology; Pflügers Archives; PloS-One; Neuroscience; Br. J. Pharmacol; Am J Physiol – Renal/Comparative/Circulatory/Gastroint Liver; Nephron; Cell Physiol Biochem; Acta Physiol Scand; Cerebrospinal Fluid Research; Cell Physiol Biochem; FEBS Lett.
Grant review: National Science Foundation (USA); Medical Research Council (UK).
Editorial Board of Am J Physiol – Renal Physiol (2005-08).
Chairman for sessions at Experimental Biology, FASEB, USA (2004, 2011x2) and multiple international symposia GF center or EU network meetings.
Organizer and chairman of session at the 38. Meeting on Membrane Transport, Sandbjerg Gods, AU (2006). Organiser and chairman for Experimental Biology symposium, FASEB (2012, 2013) and arranged an accepted symposium for the same series in 2014. Main organizer, keynote speaker, and session chairman 4. meeting on Molecular Approaches to Membrane Transport, Scand Phys Soc, Sigtuna, SE.
Former Dept. Anatomy, AU: vice-head of Institute (2008-2011), the animal facility board (2005-10), member of teaching board (2006-), research board (2007-11).
Dept. Biomedicine, AU: member of institute forum (2011-13) and research board (2011-13), vice-head of Department (2011-12). Member of the Center for Transgene Technology, AU (2006-), Member of the Water and Salt Research Center board, AU (2007-11). Current member of the research network Membranes (interdiciplinary, AU), and the AU Ideas pilot center, InterPrET.

Main local collaborators

Health, AU
Helle Hasager Damkier, Department of Biomedicine
Robert A Fenton, Department of Biomedicine
Birgitte Mønster Christensen, Department of Biomedicine
Sebastian Frische, Department of Biomedicine
Christian Aalkjær, Department of Biomedicine
Ebbe Bødtkjer, Department of Biomedicine
Science and Technology, AU
Lene Niemann Nejsum, Department of Molecular Biology and Genetics
Jan J Enghild, Department of Molecular Biology and Genetics
Hans Malte and Tobias Wang, Department of Bioscience - Zoophysiology

Publications

Regulation of Ncbe in the Choroid Plexus of Mice after Hemorrhage-Induced Hydrocephalus

Johnsen, L., Friis, K. A., Ryø, L. B., Mikkelsen, J. G., Lindhardt, T. B., Knopper, R. W., Hansen, B., Praetorius, J. & Damkier, H. H., May 2022, In: The FASEB Journal. 36, S1

Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms

Uriarte, M., De Francesco, P. N., Fernández, G., Castrogiovanni, D., D'Arcangelo, M., Imbernon, M., Cantel, S., Denoyelle, S., Fehrentz, J. A., Praetorius, J., Prevot, V. & Perello, M., Dec 2021, In: Molecular and Cellular Endocrinology. 538, 12 p., 111449.

Multiple Na,K-ATPase Subunits Colocalize in the Brush Border of Mouse Choroid Plexus Epithelial Cells

Baasch Christensen, I., Cheng, L., Brewer, J. R., Bartsch, U., Fenton, R. A., H Damkier, H. & Praetorius, J., Feb 2021, In: International Journal of Molecular Sciences . 22, 4, 27 p., 1569.

The devil is in the C-tail: a NBCe1-carbonic anhydrase bicarbonate transport metabolon?

Praetorius, J., 15 Dec 2020, In: Journal of Physiology. 598, 24, p. 5595-5596 2 p.

Slimhindeimmunitet i fordøjelseskanalen

Vorup-Jensen, T., Praetorius, J., Dige, A. K. & Holm, C. K., Dec 2020, Immunologi. Holm, C. K. (ed.). 2 ed. Roskilde: FADL's Forlag, p. 213-224

NBCe2 (Slc4a5) Is Expressed in the Renal Connecting Tubules and Cortical Collecting Ducts and Mediates Base Extrusion

Barbuskaite, D., Pedersen, F. D., Christensen, H. L., Johnsen, L. Ø., Praetorius, J. & Damkier, H. H., May 2020, In: Frontiers in Physiology. 11, 560.

Acid/base transporters in CSF secretion and pH regulation

Barbuskaite, D., Damkier, H. H. & Praetorius, J., 2020, Role of the choroid plexus in health and disease. Praetorius, J., Blazer-Yost, B. & Damkier, H. H. (eds.). New York: Springer, p. 149-171 (Physiology in Health and Disease).

Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium

Christensen, I. B., Wu, Q., Bohlbro, A. S., Skals, M. G., Damkier, H. H., Hübner, C. A., Fenton, R. A. & Praetorius, J., 2020, In: Fluids and Barriers of the CNS. 17, 1, 18 p., 2.

Ion Transport in the Choroid Plexus Epithelium

Johnsen, L. Ø., Damkier, H. H. & Praetorius, J., 2020, Ion transport across epithelial tissues and disease: Ion Channels and Transporters of Epithelia in Health and Disease : Vol. 2. Hamilton, K. L. & Devor, D. C. (eds.). 2 ed. p. 333-361 (Physiology in Health and Disease).

Structure of the mammalian choroid plexus

Damkier, H. H. & Praetorius, J., 2020, Role of the choroid plexus in health and disease. Praetorius, J., Blazer-Yost, B. & Damkier, H. H. (eds.). New York: Springer, p. 1-33 (Physiology in Health and Disease).

Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice

Huebner, A. K., Maier, H., Maul, A., Nietzsche, S., Herrmann, T., Praetorius, J. & Hübner, C. A., 2019, In: Journal of the Association for Research in Otolaryngology. 20, 3, p. 233-245 13 p.

The choroid plexus sodium-bicarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH

Christensen, H. L., Barbuskaite, D., Rojek, A., Malte, H., Christensen, I. B., Füchtbauer, A. C., Füchtbauer, E-M., Wang, T., Praetorius, J. & Damkier, H. H., Oct 2018, In: The Journal of Physiology. 596, 19, p. 4709-4728 20 p.

Adenylyl cyclase 6 is required for maintaining acid-base homeostasis

Poulsen, S. B., Marin De Evsikova, C., Murali, S. K., Praetorius, J., Chern, Y., Fenton, R. A. & Rieg, T., 31 Aug 2018, In: Clinical Science. 132, 16, p. 1779-1796 18 p.

Choroid plexus epithelial cells express the adhesion protein P-cadherin at cell-cell contacts and syntaxin-4 in the luminal membrane domain

Christensen, I. B., Mogensen, E. N., Damkier, H. H. & Praetorius, J., May 2018, In: American Journal of Physiology: Cell Physiology. 314, 5, p. C519-C533 15 p.

The murine choroid plexus epithelium expresses the 2Cl-/H+-exchanger ClC-7 and Na+/H+ exchanger NHE6 in the luminal membrane domain

Damkier, H. H., Christensen, H. L., Christensen, I. B., Wu, Q., Fenton, R. A. & Praetorius, J., Apr 2018, In: American Journal of Physiology: Cell Physiology. 314, 4, p. C439-C448 10 p.

Transport across the Choroid Plexus Epithelium

Praetorius, J. & Damkier, H. H., 1 Jun 2017, In: American Journal of Physiology: Cell Physiology. 312, p. C673-C686 ajpcell.00041.2017.

The choroid plexus sodium-bicarbonate cotransporter NBCe2 regulates cerebrospinal fluid pH

Barbuskaite, D., Praetorius, J., Christensen, H. L., Rojek, A., Nielsen, H. M., Fuchtbauer, E-M., Wang, T. & Damkier, H. H., Apr 2017, In: F A S E B Journal. 31, 1 p.

The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations

Christensen, H. L., Păunescu, T. G., Matchkov, V., Barbuskaite, D., Brown, D., Damkier, H. H. & Praetorius, J., 3 Jan 2017, In: Physiological Reports. 5, 1, no. e13072.

Isolating subpopulations of human epidermal basal cells based on polyclonal serum against trypsin-resistant CSPG4 epitopes

Gunnarsson, A. P. A., Christensen, R., Prætorius, J. & Jensen, U. B., 20 Dec 2016, In: Experimental Cell Research.

Extracellular superoxide dismutase is present in secretory vesicles of human neutrophils and released upon stimulation

Iversen, M. B., Gottfredsen, R. H., Larsen, U. G., Enghild, J. J., Praetorius, J., Borregaard, N. & Petersen, S. V., Aug 2016, In: Free Radical Biology & Medicine. 97, p. 478-88 11 p.

The zinc transporter ZNT3 co-localizes with insulin in INS-1E pancreatic beta cells and influences cell survival, insulin secretion capacity, and ZNT8 expression

Smidt, K., Larsen, A., Brønden, A., Sørensen, K. S., Nielsen, J. V., Praetorius, J., Martensen, P. M. & Rungby, J., 11 Feb 2016, In: BioMetals. 29, 2, p. 287–298 12 p.

Reducing αENaC expression in kidney connecting tubule induces pseudohypoaldosteronism type 1 symptoms during K+ loading

Poulsen, S. B., Praetorius, J., Damkier, H. H., Miller, L., Nelson, R. D., Hummler, E. & Christensen, B. M., 2016, In: American Journal of Physiology: Renal Physiology. 310, 4, p. F300-F310 11 p.

Reply to Orešković et al

Damkier, H. H., Brown, P. D. & Praetorius, J., 2016, In: Physiological Reviews. 96, 4, p. 1663-4 2 p.

Renal type a intercalated cells contain albumin in organelles with aldosterone-regulated abundance

Jensen, T. B., Cheema, M. U., Szymiczek, A., Damkier, H. H. & Praetorius, J., 2015, In: PLOS ONE. 10, 4, p. e0124902

Hepatic AQP9 expression in male rats is reduced in response to PPARα agonist treatment

Lebeck, J., Cheema, M. U., Skowronski, M. T., Nielsen, S. & Praetorius, J., 4 Dec 2014, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. p. ajpgi.00407.2013

Coordinated regulation of TRPV5-mediated Ca(2+) transport in primary distal convolution cultures

van der Hagen, E. A. E., Lavrijsen, M., van Zeeland, F., Praetorius, J., Bonny, O., Bindels, R. J. M. & Hoenderop, J. G. J., Nov 2014, In: Pflügers Archiv - European Journal of Physiology. 466, 11, p. 2077-2087 11 p.

Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene

Poulsen, E. T., Runager, K., Risør, M. W., Dyrlund, T. F., Scavenius, C., Karring, H., Praetorius, J., Vorum, H., Otzen, D. E., Klintworth, G. K. & Enghild, J. J., Apr 2014, In: Proteomics - Clinical Applications. 8, 3-4, p. 168-177 10 p.

Distal Renal Tubules Are Deficient in Aggresome Formation and Autophagy upon Aldosterone Administration

Cheema, M. U., Damkier, H. H., Nielsen, J., Poulsen, E. T., Enghild, J. J., Fenton, R. A. & Praetorius, J., 2014, In: PLOS ONE. 9, 7, p. e101258

Aldosterone and angiotensin II induced protein aggregation in renal proximal tubules

Cheema, M. U., Poulsen, E. T., Enghild, J. J., Hoorn, E., Fenton, R. A. & Praetorius, J., Sep 2013, In: Physiological Reports. 1, 4, p. e00064

Assessment of the Effect of 24-Hour Aldosterone Administration on Protein Abundance in Fluorescence-Sorted Mouse Distal Renal Tubules by Mass Spectrometry

Jensen, T. B., Pisitkun, T., Hoffert, J. D., Jensen, U. B., Fenton, R. A., Praetorius, H. A., Knepper, M. A. & Prætorius, J., 2013, In: NEPHRON PHYSIOLOGY. 121, 3-4, p. p9-p15

Cerebrospinal fluid secretion by the choroid plexus

Damkier, H., Brown, P. D. & Praetorius, J., 2013, In: Physiological Reviews. 93, 4, p. 1847-92 45 p.

Essential role of the electroneutral Na+HCO3- cotransporter NBCn1 in murine duodenal acid/base balance and colonic mucus layer build-up in vivo

Singh, A. K., Xia, W., Riederer, B., Juric, M., Li, J., Zheng, W., Cinar, A., Xiao, F., Bachmann, O., Song, P., Prætorius, J., Aalkjaer, C. & Seidler, U., 2013, In: The Journal of Physiology. 591, 8, p. 2189-2204

Insulin secretion and ZnT8 gene expression are decreased by ZnT3 overexpression

Smidt, K., Sørensen, K. S., Larsen, A., Praetorius, J., Martensen, P. M. & Rungby, J., 2013, In: Diabetologia. 56, s199

Polarization of membrane associated proteins in the choroid plexus epithelium from normal and slc4a10 knockout mice

Christensen, I. B., Gyldenholm, T., Damkier, H. & Praetorius, J., 2013, In: Frontiers in Physiology. 4, p. 344

The N-terminal cytoplasmic region of NCBE displays features of an intrinsic disordered structure and represents a novel target for specific drug screening

Bjerregaard-Andersen, K., Perdreau-Dahl, H., Guldsten, H., Praetorius, J., Jensen, J. K. & Morth, J. P., 2013, In: Frontiers in Physiology. 4, p. 320

Gender-specific effect of physical training on AQP7 protein expression in human adipose tissue

Lebeck, J., Ostergård, T., Rojek, A., Füchtbauer, E-M., Lund, S. & Prætorius, J., Dec 2012, In: Acta Diabetologica. 49, Suppl 1, p. S215-S226 11 p.

17β-estradiol induces non-genomic effects in renal intercalated cells through the G-protein coupled estrogen receptor 1

Hofmeister, M. V., Damkier, H. H., Christensen, B. M., Olde, B., Leeb-Lundberg, L. M. F., Fenton, R. A., Praetorius, H. A. & Prætorius, J., 2012, In: American Journal of Physiology: Renal Physiology. 302, p. F358

Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytes

Jelen, S., Gena, P., Lebeck, J., Rojek, A., Praetorius, J., Frøkiaer, J., Fenton, R. A., Nielsen, S., Calamita, G. & Rützler, M., 2012, In: A J P: Gastrointestinal and Liver Physiology (Online). 303, 11, p. G1279-87

Brenner and Rector’s; The Kidney. Anatomy of the kidney

Nielsen, S., Kwon, T-H., Fenton, R. A. & Prætorius, J., 2012, Elsevier Saunders. 63 p.

Depletion of SLC4A11 causes cell death by apoptosis in an immortalized human corneal endothelial cell line

Liu, J., Seet, L-F., Koh, L. W., Venkatraman, A., Venkataraman, D., Mohan, R. R., Prætorius, J., Bonanno, J. A., Aung, T. & Vithana, E. N., 2012, In: Investigative Ophthalmology & Visual Science. 53, 7, p. 3270-9 10 p.

Genetic ablation of Slc4a10 alters the expression pattern of transporters involved in solute movement in the mouse choroid plexus

Damkier, H. & Praetorius, J., 2012, In: American Journal of Physiology: Cell Physiology. 302, 10, p. C1452

Handbook of Physiology; Comprehensive Physiology: Molecular physiology of the medullary collecting ducts

Fenton, R. A. & Prætorius, J., 2012, Wiley-Blackwell.

Na+-coupled bicarbonate transporters in duodenum, collecting ducts and choroid plexus

Prætorius, J., 2012, In: J N: Journal of Nephrology. 23 Suppl 16, p. S35-42

The electroneutral Na⁺:HCO₃⁻ cotransporter NBCn1 is a major pHi regulator in murine duodenum

Chen, M., Prætorius, J., Zheng, W., Xiao, F., Riederer, B., Singh, A. K., Stieger, N., Wang, J., Shull, G. E., Aalkjaer, C. & Seidler, U., 2012, In: The Journal of Physiology. 590, 14, p. 3317-33 17 p.

Disruption of Na+,HCO₃⁻ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²⁺ sensitivity, and hypertension development in mice

Boedtkjer, E., Prætorius, J., Matchkov, V. V., Stankevicius, E., Mogensen, S., Füchtbauer, A. C., Simonsen, U., Füchtbauer, E-M. & Aalkjaer, C., 26 Sep 2011, In: Circulation. 124, 17, p. 1819-1829 11 p.

Molecular physiology of the medullary collecting duct

Fenton, R. A. & Praetorius, J., 1 Apr 2011, In: Comprehensive Physiology. 1, 2, p. 1031-1056 26 p.

The TRPV5 Promoter as a Tool for Generation of Transgenic Mouse Models

Hofmeister, M. V., Füchtbauer, E-M., Fenton, R. A. & Praetorius, J., 1 Jan 2011, In: Advances in Experimental Medicine and Biology. 704, p. 277-86 10 p.

Estrogen prevents increased hepatic aquaporin-9 expression and glycerol uptake during starvation

Lebeck, J., Gena, P., O'Neill, H., Skowronski, M. T., Lund, S., Calamita, G. & Prætorius, J., 2011, In: American Journal of Physiology: Gastrointestinal and Liver Physiology.

Na+-dependent HCO3- import by the slc4a10 gene product involves Cl- export

Damkier, H. H., Aalkjaer, C. & Prætorius, J., 27 Aug 2010, In: Journal of Biological Chemistry. 285, 35, p. 26998-7007 10 p.

Epithelial pathways in choroid plexus electrolyte transport

Damkier, H. H., Brown, P. D. N. & Prætorius, J., 1 Aug 2010, In: Physiology. 25, 4, p. 239-49 11 p.

Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain

Skjolding, A. D., Rowland, I. J., Søgaard, L. V-C., Prætorius, J., Penkowa, M. & Juhler, M., 1 Jan 2010, In: Cerebrospinal Fluid Research. 7, p. 20

Ion channels and transporters in secretory and cyclically modulating ameloblasts.

Josephsen, K., Takano, Y., Frische, S., Prætorius, J., Nielsen, S., Aoba, T. & Fejerskov, O., 2010. 1 p.

Ion transporters in secretory and cyclically modulating ameloblasts: a new hypothesis for cellular control of preeruptive enamel maturation.

Josephsen, K., Takano, Y., Frische, S., Prætorius, J., Nielsen, S., Aoba, T. & Fejerskov, O., 2010, In: American Journal of Physiology: Cell Physiology. 299, p. C:1299-C:1307 9 p.

Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions

Møller, H., Praetorius, J., Rützler, M. R. & Fenton, R. A., 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 424-9 5 p.

Fluorescence-isolation of mouse late distal convoluted tubules and connecting tubules: effects of vasopressin and vitamin D3 on Ca2+ signaling.

Hofmeister, M. V., Fenton, R. & Praetorius, J., 2009, In: American Journal of Physiology: Renal Physiology. 296, 1, p. F194-203 10 p.

Na+ -coupled acid/base transporters in epithelial research: lessons from duodenum, renal tubules and choroid plexus

Prætorius, J., 2009, SUN-TRYK, Aarhus Universitet. 41 p.

Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice

Damkier, H., Prasad, V., Hübner, C. A. & Praetorius, J., 2009, In: American Journal of Physiology: Cell Physiology. 296, 6, p. C1291-300

Rapid effects of 17beta-estradiol on TRPV5 epithelial Ca2+ channels in rat renal cells

Irnaten, M., Blanchard-Gutton, N., Praetorius, J. & Harvey, B. J., 2009, In: Steroids. 74, 8, p. 642-9 7 p.

Targeted disruption of the Cl-/HCO3-exchanger Ae2 results in osteopetrosis in mice

Josephsen, K., Prætorius, J., Frische, S., Gawenis, L. R., Kwon, T-H., Agre, P., Nielsen, S. & Fejerskov, O., 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 5, p. 1638-1641 4 p.

A current view of the mammalian aquaglyceroporins

Rojek, A., Prætorius, J., Frøkiær, J., Nielsen, S. & Fenton, R., 2008, In: Annual Review of Physiology. 70, p. 301-27

A current view of the mammalian aquaglyceroporins

Rojek, A., Praetorius, J., Frøkiaer, J., Nielsen, S. & Fenton, R. A., 2008, In: Annual Review of Physiology. 70, p. 301-27 27 p.

Antibody-independent localization of the electroneutral Na+-HCO3- cotransporter NBCn1 (slc4a7) in mice

Bødtkjer, E., Prætorius, J., Füchtbauer, E-M. & Aalkjær, C., 2008, In: American Journal of Physiology: Cell Physiology. 294, 2, p. C591-C603 13 p.

Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability

Jacobs, S., Ruusuvuori, E., Sipilä, S. T., Haapanen, A., Damkier, H., Kurth, I., Hentschke, M., Schweizer, M., Rudhard, Y., Laatikainen, L. M., Tyynelä, J., Prætorius, J., Voipio, J. & Hübner, C. A., 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 1, p. 311-6

Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney

Fenton, R. A., Brønd, L., Nielsen, S. & Praetorius, J., 1 Sep 2007, In: American Journal of Physiology - Renal Physiology. 293, 3

AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism

Skowronski, M., Lebeck, J., Rojek, A., Prætorius, J., Füchtbauer, E-M., Frøkiær, J. & Nielsen, S., 2007, In: American Journal of Physiology: Renal Physiology. 292, 3, p. F956-65

Cellular and subcellular distribution of the type-2 vasopressin receptor in kidney

Fenton, R., Miller, L. B., Nielsen, S. & Prætorius, J., 2007, In: American Journal of Physiology: Renal Physiology. 293, 3, p. F748-60

Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure

Torp, M., Brønd, L., Hadrup, N., Nielsen, JB., Prætorius, J., Nielsen, S., Christensen, S. & Jonassen, T. E., 2007, In: Acta Physiol (Oxf.). 190, 4, p. 339-50

Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues

Damkier, H., Nielsen, S. & Prætorius, J., 2007, In: Am. J. Physiol. Regul. Integr. Comp. Physiol.. 293, 5, p. R2136-45

Vacuolar H+-ATPase expression is increased in acid-secreting intercalated cells in kidneys of rats with hypercalcaemia-induced alkalosis

Wang, W., Prætorius, J., Li, C., Prætorius, H., Kwon, T-H., Frøkiær, J. & Nielsen, S., 2007, In: Acta Physiol (Oxf.). 189, 4, p. 359-68

Water and solute secretion by the choroid plexus

Prætorius, J., 2007, In: Pflügers Archiv - European Journal of Physiology. 454, 1, p. 1-18

Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus

Nielsen, J., Kwon, T-H., Prætorius, J., Frøkiær, J., Knepper, M. A. & Nielsen, S., 2006, In: American Journal of Physiology: Renal Physiology. 290, 2, p. F438-49

An anti-NH2-terminal antibody localizes NBCn1 to heart endothelia and skeletal and vascular smooth muscle cells

Damkier, H. H., Nielsen, S. & Prætorius, J., 2006, In: Am. J. Physiol. Heart Circ Physiol. 290, 1, p. H172-H180

Aquaporin-11: a channel protein lacking apparent transport function expressed in brain

Gorelick, D. A., Prætorius, J., Tsunenari, T., Nielsen, S. & Agre, P., 2006, In: BMC Biochem. 7, p. 14

Distribution of sodium transporters and aquaporin-1 in the human choroid plexus

Prætorius, J. & Nielsen, S., 2006, In: Am. J. Physiol. (Cell Physiol.). 291, 1, p. C59-67

NBCn1 (slc4a7) mediates the Na+-dependent bicarbonate transport important for regulation of intracellular pH in mouse vascular smooth muscle cells

Bødtkjer, E., Prætorius, J. & Aalkjær, C., 2006, In: Circulation Research. 98, 4, p. 515-23

Successful treatment of a patient with primary Sjogren's syndrome with Rituximab

Ring, T., Kallenbach, M., Prætorius, J., Nielsen, S. & Melgaard, B., 2006, In: Clin Rheumatol. 25, 6, p. 891-4

NKCC1 and NHE1 are abundantly expressed in the basolateral plasma membrane of secretory coil cells in rat, mouse, and human sweat glands.

Nejsum, L. N., Prætorius, J. & Nielsen, S., 2005, In: American Journal of Physiology: Cell Physiology. 289, 2, p. C333-340 8 p.

Na+-dependent HCO3- uptake into the rat choroid plexus epithelium is partially DIDS sensitive.

Bouzinova, E. V., Prætorius, J., Virkki, L. V., Nielsen, S., Boron, W. F. & Aalkjær, C., 2005, In: Am. J. Physiol.. 289, p. C1448-C1456

A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells

Praetorius, J., Nejsum, L. N. & Nielsen, S., 1 Mar 2004, In: American Journal of Physiology: Cell Physiology. 286, 3, p. C601-10

AE2 isoforms in rat kidney: immunohistochemical localization and regulation in response to chronic NH4Cl loading

Frische, S., Zolotarev, A. S., Kim, Y-H., Prætorius, J., Alper, S., Nielsen, S. & Wall, S. M., 2004, In: American Journal of Physiology: Renal Physiology. 286, 6, p. F1163-70

Basolateral Na+-dependent HCO3- transporter NBCn1-mediated HCO3- influx in rat medullary thick ascending limb

Odgaard, E. V. P., Jakobsen, J. K., Frische, S., Prætorius, J., Nielsen, S., Aalkjær, C. & Leipziger, J. G., 2004, In: J. Physiol.. 555, 1, p. 205-218

Betal-integrins in the primary cilium of MDCK cells potentiate fibronectin-induced Ca2+ signalling

Prætorius, H., Prætorius, J., Nielsen, S., Frøkiær, J. & Spring, K. R., 2004, In: American Journal of Physiology: Renal Physiology. 287, 5, p. 969-978 10 p.

Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats

Kim, S. W., Wang, W., Nielsen, J., Prætorius, J., Kwon, T-H., Knepper, M. A., Frøkiaer, J. & Nielsen, S., 2004, In: American Journal of Physiology: Renal Physiology. 286, 5, p. F922-35

NBCn1 is a basolateral Na+-HCO3- cotransporter in rat kidney inner medullary collecting ducts

Prætorius, J., Kim, Y-H., Bouzinova, E. V., Frische, S., Rojek, A., Aalkjær, C. & Nielsen, S., 2004, In: American Journal of Physiology: Renal Physiology. 286, 5, p. F903-F912

Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation

Hadrup, N., Petersen, J., Prætorius, J., Meier, E., Graebe, M., Brønd, L., Staahltoft, D., Nielsen, S., Christensen, S., Kapusta, D. R. & Jonassen, T. E. N., 2004, In: American Journal of Physiology: Renal Physiology. 287, 1, p. F160-8

Sodium coupled bicarbonate transporters in the kidney, an update

Aalkjær, C., Frische, S., Leipziger, J. G., Nielsen, S. & Prætorius, J., 2004, In: Acta Physiologica (Print). 181, 4, p. 505-512

Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver

Carbrey, J. M., Gorelick-Feldman, D. A., Kozono, D., Prætorius, J., Nielsen, S. & Agre, P., 2003, In: Proceedings of the National Academy of Sciences of the United States of America. 100, 5, p. 2945-50 6 p.

Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI

Nielsen, J., Kwon, T-H., Prætorius, J., Kim, Y-H., Frøkiær, J., Knepper, M. A. & Nielsen, S., 2003, In: American Journal of Physiology: Renal Physiology. 285, 6, p. F1198-F1209

Specific lectins map the distribution of fibronectin and beta 1-integrin on living MDCK cells

Prætorius, J. & Spring, K. R., 2002, In: Experimental Cell Research. 276, 1, p. 52-62 11 p.

The cystic fibrosis transmembrane conductance regulator is not a base transporter in isolated duodenal epithelial cells

Prætorius, J., Friis, U. G., Ainsworth, M. A., Schaffalitzky de Muckadell, OB. & Johansen, T., 2002, In: Acta Physiologica (Print). 174, 4, p. 327-336

Specific lectin binding to beta1 integrin and fibronectin on the apical membrane of madin-darby canine kidney cells

Praetorius, J., Backlund, P., Yergey, A. L. & Spring, K. R., 1 Dec 2001, In: Journal of Membrane Biology. 184, 3, p. 273-81 9 p.

Molecular and functional evidence for electrogenic and electroneutral Na(+)-HCO(3)(-) cotransporters in murine duodenum

Praetorius, J., Hager, H., Nielsen, S., Aalkjaer, C., Friis, U. G., Ainsworth, M. A. & Johansen, T., Mar 2001, In: A J P: Gastrointestinal and Liver Physiology (Online). 280, 3, p. G332-43

NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells

Prætorius, J., Andreasen, D., Jensen, B. L., Ainsworth, M. A., Friis, U. G. & Johansen, T., 2000, In: Am. J. Physiol. Gastrointest. Liver Physiol.. 278, 2, p. G197-G206

Evidence for a Na+/Ca2+ exchange mechanism in rat peritoneal mast cells

Prætorius, H., Friis, U. G., Prætorius, J., Knudsen, T. & Johansen, T., 1998, In: Pflügers Archiv - European Journal of Physiology. 184, p. 71-79