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Jens Randel Nyengaard

The number of glomeruli in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients.

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  • Stereological Research Laboratory
  • Institute of Clinical Medicine
  • The Department of Pathology - ÅKH
The number of glomeruli per kidney in Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic patients was estimated by an unbiased stereological method: the fractionator. No significant differences were observed between Type 1 and Type 2 diabetic patients without severe diabetic glomerulopathy and non-diabetic patients. Diabetic patients with proteinuria who were in the early stages of diabetic nephropathy also had a normal number of glomeruli. On the other hand, a subgroup classified as Type 1 diabetic patients with severe diabetic glomerulopathy had significantly less glomeruli compared with Type 1 diabetic patients with mild or no glomerulopathy. A probable explanation is that Type 1 diabetic patients lose glomeruli in relation to the progression of diabetic glomerulopathy. A more theoretical alternative is, however, that development of diabetic glomerulopathy is facilitated by a low number of glomeruli.
Original languageEnglish
JournalDiabetologia
Volume35
Issue9
Pages (from-to)844-850
Number of pages6
ISSN0012-186X
Publication statusPublished - 1992

    Research areas

  • Adolescent, Adult, Aged, Aged, 80 and over, Autopsy, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Kidney Glomerulus, Male, Middle Aged, Regression Analysis

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