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Jens Randel Nyengaard

The developing left superior cervical ganglion of Pacas (Agouti paca)

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  • Samanta Rios Melo, Denmark
  • Jens Randel Nyengaard
  • Felipe da Roza Oliveira, Denmark
  • Fernando Vagner Lobo Ladd, Denmark
  • Luciana Maria Bigaram Abrahão, Denmark
  • Márcia R F Machado, Denmark
  • Tais H C Sasahara, Denmark
  • Mariana Pereira de Melo, Denmark
  • Antonio Augusto C M Ribeiro, Denmark
  • Stereological Research Laboratory
In this study the main question investigated was the number and size of both binucleate and mononucleate superior cervical ganglion (SCG) neurons and, whether post-natal development would affect these parameters. Twenty left SCGs from 20 male pacas were used. Four different ages were investigated, that is newborn (4 days), young (45 days), adult (2 years), and aged animals (7 years). By using design-based stereological methods, that is the Cavalieri principle and a physical disector combined with serial sectioning, the total volume of ganglion and total number of mononucleate and binucleate neurons were estimated. Furthermore, the mean perikaryal (somal) volume of mononucleate and binucleate neurons was estimated using the vertical nucleator. The main findings of this study were a 154% increase in the SCG volume, a 95% increase in the total number of mononucleate SCG neurons and a 50% increase in the total volume of SCG neurons. In conclusion, apart from neuron number, different adaptive mechanisms may coexist in the autonomic nervous system to guarantee a functional homeostasis during ageing, which is not always associated with neuron losses.
Original languageEnglish
JournalAnatomical record (Hoboken, N.J. : 2007)
Volume292
Issue7
Pages (from-to)966-75
Number of pages9
DOIs
Publication statusPublished - 2009

    Research areas

  • Aging, Animals, Autonomic Pathways, Cardiovascular Physiological Phenomena, Cell Count, Cell Nucleus, Cell Proliferation, Cell Size, Functional Laterality, Male, Neurogenesis, Neurons, Rodentia, Species Specificity, Superior Cervical Ganglion, Sympathetic Fibers, Postganglionic

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