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Jens Randel Nyengaard

Stereological estimation of total cell numbers in the young human utricular macula

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Standard

Stereological estimation of total cell numbers in the young human utricular macula. / Severinsen, Stig Avall; Sørensen, Mads Sølvsten; Kirkegaard, Mette; Nyengaard, Jens R.

In: Acta Oto-Laryngologica, Vol. 130, No. 7, 01.07.2010, p. 773-779.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Severinsen, SA, Sørensen, MS, Kirkegaard, M & Nyengaard, JR 2010, 'Stereological estimation of total cell numbers in the young human utricular macula', Acta Oto-Laryngologica, vol. 130, no. 7, pp. 773-779. https://doi.org/10.3109/00016480903397694

APA

Severinsen, S. A., Sørensen, M. S., Kirkegaard, M., & Nyengaard, J. R. (2010). Stereological estimation of total cell numbers in the young human utricular macula. Acta Oto-Laryngologica, 130(7), 773-779. https://doi.org/10.3109/00016480903397694

CBE

MLA

Vancouver

Severinsen SA, Sørensen MS, Kirkegaard M, Nyengaard JR. Stereological estimation of total cell numbers in the young human utricular macula. Acta Oto-Laryngologica. 2010 Jul 1;130(7):773-779. https://doi.org/10.3109/00016480903397694

Author

Severinsen, Stig Avall ; Sørensen, Mads Sølvsten ; Kirkegaard, Mette ; Nyengaard, Jens R. / Stereological estimation of total cell numbers in the young human utricular macula. In: Acta Oto-Laryngologica. 2010 ; Vol. 130, No. 7. pp. 773-779.

Bibtex

@article{adca4336893346bdbfefd9f2afbfb239,
title = "Stereological estimation of total cell numbers in the young human utricular macula",
abstract = "Abstract Conclusion: There is no change in the total cell population and hair cell:supporting cell ratio in the human utricular macula from gestational week 16 and onwards, whereas the lower hair cell:supporting cell ratio and lower total number of cells in the youngest specimens indicate that the utricle is still differentiating and adding new cells at the 10th to 12th gestational week. Objectives: Archival temporal bones were investigated to quantify cell numbers in the utricular macula in fetuses and children. Methods: The age of the subjects ranged from gestational week 10 to 15 years. The optical fractionator was used to estimate the total number of cells in the utricular macula. Results: The total cell number was found to be 143 000 in subjects older than gestational week 16. The number of hair cells and supporting cells did not change between the 16th gestational week and 15 years and was 36 000 and 107 000, respectively. In the youngest specimen (10th and 12th gestational week) there was a statistically significant lower total number of cells (62 000) and a lower hair cell:supporting cell ratio, resulting in a mean number of 13 000 hair cells and 49 000 supporting cells.",
author = "Severinsen, {Stig Avall} and S{\o}rensen, {Mads S{\o}lvsten} and Mette Kirkegaard and Nyengaard, {Jens R}",
year = "2010",
month = jul,
day = "1",
doi = "10.3109/00016480903397694",
language = "English",
volume = "130",
pages = "773--779",
journal = "Acta Oto-Laryngologica",
issn = "0001-6489",
publisher = "Taylor & Francis ",
number = "7",

}

RIS

TY - JOUR

T1 - Stereological estimation of total cell numbers in the young human utricular macula

AU - Severinsen, Stig Avall

AU - Sørensen, Mads Sølvsten

AU - Kirkegaard, Mette

AU - Nyengaard, Jens R

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Abstract Conclusion: There is no change in the total cell population and hair cell:supporting cell ratio in the human utricular macula from gestational week 16 and onwards, whereas the lower hair cell:supporting cell ratio and lower total number of cells in the youngest specimens indicate that the utricle is still differentiating and adding new cells at the 10th to 12th gestational week. Objectives: Archival temporal bones were investigated to quantify cell numbers in the utricular macula in fetuses and children. Methods: The age of the subjects ranged from gestational week 10 to 15 years. The optical fractionator was used to estimate the total number of cells in the utricular macula. Results: The total cell number was found to be 143 000 in subjects older than gestational week 16. The number of hair cells and supporting cells did not change between the 16th gestational week and 15 years and was 36 000 and 107 000, respectively. In the youngest specimen (10th and 12th gestational week) there was a statistically significant lower total number of cells (62 000) and a lower hair cell:supporting cell ratio, resulting in a mean number of 13 000 hair cells and 49 000 supporting cells.

AB - Abstract Conclusion: There is no change in the total cell population and hair cell:supporting cell ratio in the human utricular macula from gestational week 16 and onwards, whereas the lower hair cell:supporting cell ratio and lower total number of cells in the youngest specimens indicate that the utricle is still differentiating and adding new cells at the 10th to 12th gestational week. Objectives: Archival temporal bones were investigated to quantify cell numbers in the utricular macula in fetuses and children. Methods: The age of the subjects ranged from gestational week 10 to 15 years. The optical fractionator was used to estimate the total number of cells in the utricular macula. Results: The total cell number was found to be 143 000 in subjects older than gestational week 16. The number of hair cells and supporting cells did not change between the 16th gestational week and 15 years and was 36 000 and 107 000, respectively. In the youngest specimen (10th and 12th gestational week) there was a statistically significant lower total number of cells (62 000) and a lower hair cell:supporting cell ratio, resulting in a mean number of 13 000 hair cells and 49 000 supporting cells.

U2 - 10.3109/00016480903397694

DO - 10.3109/00016480903397694

M3 - Journal article

C2 - 20082566

VL - 130

SP - 773

EP - 779

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

SN - 0001-6489

IS - 7

ER -