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Jens Randel Nyengaard

Reduced infarct size in neuroglobin-null mice after experimental stroke in vivo

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  • Zindy Raida, NeuroCluster, Denmark
  • Christian Ansgar Hundahl, Denmark
  • Jesper Kelsen, Denmark
  • Jens Randel Nyengaard
  • Anders Hay-Schmidt, Institut for Neurovidenskab og Farmakologi, Denmark
Neuroglobin is considered to be a novel important pharmacological target in combating stroke and neurodegenerative disorders, although the mechanism by which this protection is accomplished remains an enigma. We hypothesized that if neuroglobin is directly involved in neuroprotection, then permanent cerebral ischemia would lead to larger infarct volumes in neuroglobin-null mice than in wild-type mice.
Original languageEnglish
JournalExperimental & Translational Stroke Medicine
Volume4
Issue1
Pages (from-to)1-12
Number of pages12
ISSN2040-7378
DOIs
Publication statusPublished - 20 Aug 2012

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