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Jens Randel Nyengaard

Neuroglobin over expressing mice: expression pattern and effect on brain ischemic infarct size

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  • Zindy Raida, Institut for Neurovidenskab og Farmakologi, Denmark
  • Christian Ansgar Hundahl, Denmark
  • Jens R Nyengaard
  • Anders Hay-Schmidt, Laboratorium for Neural Plasticitet, Denmark
Stroke is a major cause of death and severe disability, but effective treatments are limited. Neuroglobin, a neuronal heme-globin, has been advocated as a novel pharmacological target in combating stroke and neurodegenerative disorders based on cytoprotective properties. Using thoroughly validated antibodies and oligos, we give a detailed brain anatomical characterization of transgenic mice over expressing Neuroglobin. Moreover, using permanent middle artery occlusion the effect of elevated levels of Neuroglobin on ischemic damage was studied. Lastly, the impact of mouse strain genetic background on ischemic damage was investigated.
Original languageEnglish
JournalPLOS ONE
Volume8
Issue10
Pages (from-to)e76565
Number of pages13
ISSN1932-6203
DOIs
Publication statusPublished - 2013

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