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Jens Randel Nyengaard

Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Frömter rat

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  • Angela Schulz, Denmark
  • Jonna Hänsch, Denmark
  • Kristina Kuhn, Denmark
  • Maria Schlesener, Denmark
  • Peter Kossmehl, Denmark
  • Jens R Nyengaard
  • Norbert Wendt, Denmark
  • Matthias Huber, Denmark
  • Reinhold Kreutz, Denmark
  • Stereological Research Laboratory
The Munich Wistar Frömter (MWF) rat represents a genetic model with an inherited nephron deficit and exhibits mild hypertension and progressive albuminuria, which is more pronounced in males than females. Previously, we demonstrated in a consomic strain that replacement of a quantitative trait locus on chromosome 6 normalized the nephron deficit and suppressed albuminuria development, suggesting a link between the two findings. Here we tested the role of a second major locus linked to albuminuria in MWF on chromosome 8 and generated the consomic strain MWF-8(SHR) by transfer of chromosome 8 from spontaneously hypertensive rats (SHR) into MWF. The early onset of albuminuria at 8 wk of age in MWF (>50-fold increase compared with SHR) was significantly suppressed in consomic animals, and the development of marked proteinuria at 32 wk significantly diminished. Total nephron number in consomic rats (23,771 +/- 1,352) and MWF (27,028 +/- 1,322) were similar and significantly lower (-36%) compared with SHR (36,979 +/- 1,352, P < 0.0001). The development of mild albuminuria in female MWF was also significantly diminished in MWF-8(SHR). Thus, the development of overt and mild albuminuria in male and female MWF rats is not a mandatory consequence of the inherited nephron deficit. The locus on chromosome 8 appears of interest, because its exchange between MWF and SHR protects against the development of albuminuria in MWF-8(SHR) animals despite their inherited nephron deficit and higher systolic blood pressure.
Original languageEnglish
JournalPhysiological Genomics
Volume35
Issue1
Pages (from-to)30-5
Number of pages5
ISSN1094-8341
DOIs
Publication statusPublished - 2008

    Research areas

  • Albuminuria, Animals, Animals, Congenic, Chromosomes, Mammalian, Female, Hypertension, Male, Nephrons, Rats, Rats, Inbred SHR, Sex Characteristics

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