Jens Randel Nyengaard

Mannan-binding lectin in diabetic kidney disease: the impact of mouse genetics in a type 1 diabetes model

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BACKGROUND. Mannan-binding lectin (MBL) is involved in the development of diabetic nephropathy. MBL is a part of the innate immune system where it can activate the complement system. Serum MBL level predicts later renal impairment in diabetes patients. Direct involvement of MBL in the development of diabetic kidney disease is observed in one animal strain. However, this involvement may differ among the animal strains. We thus examined the impact of the genetic background on the role of MBL in diabetic nephropathy.
Original languageEnglish
JournalExperimental Diabetes Research
Volume2012
Pages (from-to)678381
ISSN1687-5214
DOIs
Publication statusPublished - 2012

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