Jens Randel Nyengaard

Left ventricular morphology of the giraffe heart examined by stereological methods

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Left ventricular morphology of the giraffe heart examined by stereological methods. / Østergaard, Kristine Hovkjær; Baandrup, Ulrik; Wang, Tobias; Bertelsen, Mads F; Andersen, Johnnie B; Smerup, Morten Holdgaard; Nyengaard, Jens R.

In: Anatomical Record, Vol. 296, No. 4, 04.2013, p. 611-21.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Østergaard, KH, Baandrup, U, Wang, T, Bertelsen, MF, Andersen, JB, Smerup, MH & Nyengaard, JR 2013, 'Left ventricular morphology of the giraffe heart examined by stereological methods', Anatomical Record, vol. 296, no. 4, pp. 611-21. https://doi.org/10.1002/ar.22672

APA

Østergaard, K. H., Baandrup, U., Wang, T., Bertelsen, M. F., Andersen, J. B., Smerup, M. H., & Nyengaard, J. R. (2013). Left ventricular morphology of the giraffe heart examined by stereological methods. Anatomical Record, 296(4), 611-21. https://doi.org/10.1002/ar.22672

CBE

MLA

Østergaard, Kristine Hovkjær et al. "Left ventricular morphology of the giraffe heart examined by stereological methods". Anatomical Record. 2013, 296(4). 611-21. https://doi.org/10.1002/ar.22672

Vancouver

Østergaard KH, Baandrup U, Wang T, Bertelsen MF, Andersen JB, Smerup MH et al. Left ventricular morphology of the giraffe heart examined by stereological methods. Anatomical Record. 2013 Apr;296(4):611-21. https://doi.org/10.1002/ar.22672

Author

Østergaard, Kristine Hovkjær ; Baandrup, Ulrik ; Wang, Tobias ; Bertelsen, Mads F ; Andersen, Johnnie B ; Smerup, Morten Holdgaard ; Nyengaard, Jens R. / Left ventricular morphology of the giraffe heart examined by stereological methods. In: Anatomical Record. 2013 ; Vol. 296, No. 4. pp. 611-21.

Bibtex

@article{9568b92e712f4c3dbd77a1ae7d19bc56,
title = "Left ventricular morphology of the giraffe heart examined by stereological methods",
abstract = "The giraffe heart has a relative mass similar to other mammals, but generates twice the blood pressure to overcome the gravitational challenge of perfusing the cerebral circulation. To provide insight as to how the giraffe left ventricle (LV) is structurally adapted to tackle such a high afterload, we performed a quantitative structural study of the LV myocardium in young and adult giraffe hearts. Tissue samples were collected from young and adult giraffe LV. Design-based stereology was used to obtain unbiased estimates of numbers and sizes of cardiomyocytes, nuclei and capillaries. The numerical density of myocyte nuclei was 120 × 10(3) mm(-3) in the adult and 504 × 10(3) mm(-3) in the young LV. The total number (N) of myocyte nuclei was 1.3 × 10(11) in the adult LV and 4.9 × 10(10) in the young LV. In the adult LV the volume per myocyte was 39.5 × 10(3) µm(3) and the number of nuclei per myocyte was 4.2. The numerical density of myocytes was 24.1 × 10(6) cm(-3) and the capillary volume fraction of the adult giraffe ventricle was 0.054. The significantly higher total number of myocyte nuclei in the adult LV, the high density of myocyte nuclei in the LV, and the number of nuclei per myocyte (which was unusually high compared to other mammalian, including human data), all suggest the presence of myocyte proliferation during growth of the animal to increase wall thickness and normalize LV wall tension as the neck lengthens and the need for higher blood pressure ensues. Anat Rec, 296:611-621, 2013. {\textcopyright} 2013 Wiley Periodicals, Inc.",
author = "{\O}stergaard, {Kristine Hovkj{\ae}r} and Ulrik Baandrup and Tobias Wang and Bertelsen, {Mads F} and Andersen, {Johnnie B} and Smerup, {Morten Holdgaard} and Nyengaard, {Jens R}",
note = "Copyright {\textcopyright} 2013 Wiley Periodicals, Inc.",
year = "2013",
month = apr,
doi = "10.1002/ar.22672",
language = "English",
volume = "296",
pages = "611--21",
journal = "Anatomical Record",
issn = "1932-8486",
publisher = "Wiley",
number = "4",

}

RIS

TY - JOUR

T1 - Left ventricular morphology of the giraffe heart examined by stereological methods

AU - Østergaard, Kristine Hovkjær

AU - Baandrup, Ulrik

AU - Wang, Tobias

AU - Bertelsen, Mads F

AU - Andersen, Johnnie B

AU - Smerup, Morten Holdgaard

AU - Nyengaard, Jens R

N1 - Copyright © 2013 Wiley Periodicals, Inc.

PY - 2013/4

Y1 - 2013/4

N2 - The giraffe heart has a relative mass similar to other mammals, but generates twice the blood pressure to overcome the gravitational challenge of perfusing the cerebral circulation. To provide insight as to how the giraffe left ventricle (LV) is structurally adapted to tackle such a high afterload, we performed a quantitative structural study of the LV myocardium in young and adult giraffe hearts. Tissue samples were collected from young and adult giraffe LV. Design-based stereology was used to obtain unbiased estimates of numbers and sizes of cardiomyocytes, nuclei and capillaries. The numerical density of myocyte nuclei was 120 × 10(3) mm(-3) in the adult and 504 × 10(3) mm(-3) in the young LV. The total number (N) of myocyte nuclei was 1.3 × 10(11) in the adult LV and 4.9 × 10(10) in the young LV. In the adult LV the volume per myocyte was 39.5 × 10(3) µm(3) and the number of nuclei per myocyte was 4.2. The numerical density of myocytes was 24.1 × 10(6) cm(-3) and the capillary volume fraction of the adult giraffe ventricle was 0.054. The significantly higher total number of myocyte nuclei in the adult LV, the high density of myocyte nuclei in the LV, and the number of nuclei per myocyte (which was unusually high compared to other mammalian, including human data), all suggest the presence of myocyte proliferation during growth of the animal to increase wall thickness and normalize LV wall tension as the neck lengthens and the need for higher blood pressure ensues. Anat Rec, 296:611-621, 2013. © 2013 Wiley Periodicals, Inc.

AB - The giraffe heart has a relative mass similar to other mammals, but generates twice the blood pressure to overcome the gravitational challenge of perfusing the cerebral circulation. To provide insight as to how the giraffe left ventricle (LV) is structurally adapted to tackle such a high afterload, we performed a quantitative structural study of the LV myocardium in young and adult giraffe hearts. Tissue samples were collected from young and adult giraffe LV. Design-based stereology was used to obtain unbiased estimates of numbers and sizes of cardiomyocytes, nuclei and capillaries. The numerical density of myocyte nuclei was 120 × 10(3) mm(-3) in the adult and 504 × 10(3) mm(-3) in the young LV. The total number (N) of myocyte nuclei was 1.3 × 10(11) in the adult LV and 4.9 × 10(10) in the young LV. In the adult LV the volume per myocyte was 39.5 × 10(3) µm(3) and the number of nuclei per myocyte was 4.2. The numerical density of myocytes was 24.1 × 10(6) cm(-3) and the capillary volume fraction of the adult giraffe ventricle was 0.054. The significantly higher total number of myocyte nuclei in the adult LV, the high density of myocyte nuclei in the LV, and the number of nuclei per myocyte (which was unusually high compared to other mammalian, including human data), all suggest the presence of myocyte proliferation during growth of the animal to increase wall thickness and normalize LV wall tension as the neck lengthens and the need for higher blood pressure ensues. Anat Rec, 296:611-621, 2013. © 2013 Wiley Periodicals, Inc.

U2 - 10.1002/ar.22672

DO - 10.1002/ar.22672

M3 - Journal article

C2 - 23420662

VL - 296

SP - 611

EP - 621

JO - Anatomical Record

JF - Anatomical Record

SN - 1932-8486

IS - 4

ER -