Jens Randel Nyengaard

Hyperglycemic pseudohypoxia and diabetic complications

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Standard

Hyperglycemic pseudohypoxia and diabetic complications. / Williamson, Joseph R.; Chang, Katherine; Frangos, Myrto; Hasan, Khalid S.; Ido, Yasuo; Kawamura, Takahiko; Nyengaard, Jens R.; Van Den Enden, Maria; Kilo, Charles; Tilton, Ronald G.

In: Diabetes, Vol. 42, No. 6, 01.01.1993, p. 801-813.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Williamson, JR, Chang, K, Frangos, M, Hasan, KS, Ido, Y, Kawamura, T, Nyengaard, JR, Van Den Enden, M, Kilo, C & Tilton, RG 1993, 'Hyperglycemic pseudohypoxia and diabetic complications', Diabetes, vol. 42, no. 6, pp. 801-813. https://doi.org/10.2337/diab.42.6.801

APA

Williamson, J. R., Chang, K., Frangos, M., Hasan, K. S., Ido, Y., Kawamura, T., Nyengaard, J. R., Van Den Enden, M., Kilo, C., & Tilton, R. G. (1993). Hyperglycemic pseudohypoxia and diabetic complications. Diabetes, 42(6), 801-813. https://doi.org/10.2337/diab.42.6.801

CBE

Williamson JR, Chang K, Frangos M, Hasan KS, Ido Y, Kawamura T, Nyengaard JR, Van Den Enden M, Kilo C, Tilton RG. 1993. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 42(6):801-813. https://doi.org/10.2337/diab.42.6.801

MLA

Williamson, Joseph R. et al. "Hyperglycemic pseudohypoxia and diabetic complications". Diabetes. 1993, 42(6). 801-813. https://doi.org/10.2337/diab.42.6.801

Vancouver

Williamson JR, Chang K, Frangos M, Hasan KS, Ido Y, Kawamura T et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993 Jan 1;42(6):801-813. https://doi.org/10.2337/diab.42.6.801

Author

Williamson, Joseph R. ; Chang, Katherine ; Frangos, Myrto ; Hasan, Khalid S. ; Ido, Yasuo ; Kawamura, Takahiko ; Nyengaard, Jens R. ; Van Den Enden, Maria ; Kilo, Charles ; Tilton, Ronald G. / Hyperglycemic pseudohypoxia and diabetic complications. In: Diabetes. 1993 ; Vol. 42, No. 6. pp. 801-813.

Bibtex

@article{891c0df81132454895f90b044fd8a691,
title = "Hyperglycemic pseudohypoxia and diabetic complications",
abstract = "Vasodilation and increased blood flow are characteristic early vascular responses to acute hyperglycemia and tissue hypoxia. In hypoxic tissues these vascular changes are linked to metabolic imbalances associated with impaired oxidation of NADH to NAD+ and the resulting increased ratio of NADH/NAD+. In hyperglycemic tissues these vascular changes also are linked to an increased ratio of NADH/NAD+, in this case because of an increased rate of reduction of NAD+ to NADH. Several lines of evidence support the likelihood that the increased cytosolic ratio of free NADH/NAD+ caused by hyperglycemia, referred to as pseudohypoxia because tissue partial pressure oxygen is normal, is a characteristic feature of poorly controlled diabetes that mimics the effects of true hypoxia on vascular and neural function and plays an important role in the pathogenesis of diabetic complications. These effects of hypoxia and hyperglycemia-induced pseudohypoxia on vascular and neural function are mediated by a branching cascade of imbalances in lipid metabolism, increased production of superoxide anion, and possibly increased nitric oxide formation.",
author = "Williamson, {Joseph R.} and Katherine Chang and Myrto Frangos and Hasan, {Khalid S.} and Yasuo Ido and Takahiko Kawamura and Nyengaard, {Jens R.} and {Van Den Enden}, Maria and Charles Kilo and Tilton, {Ronald G.}",
year = "1993",
month = jan,
day = "1",
doi = "10.2337/diab.42.6.801",
language = "English",
volume = "42",
pages = "801--813",
journal = "Diabetes",
issn = "0012-1797",
publisher = "AMER DIABETES ASSOC",
number = "6",

}

RIS

TY - JOUR

T1 - Hyperglycemic pseudohypoxia and diabetic complications

AU - Williamson, Joseph R.

AU - Chang, Katherine

AU - Frangos, Myrto

AU - Hasan, Khalid S.

AU - Ido, Yasuo

AU - Kawamura, Takahiko

AU - Nyengaard, Jens R.

AU - Van Den Enden, Maria

AU - Kilo, Charles

AU - Tilton, Ronald G.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Vasodilation and increased blood flow are characteristic early vascular responses to acute hyperglycemia and tissue hypoxia. In hypoxic tissues these vascular changes are linked to metabolic imbalances associated with impaired oxidation of NADH to NAD+ and the resulting increased ratio of NADH/NAD+. In hyperglycemic tissues these vascular changes also are linked to an increased ratio of NADH/NAD+, in this case because of an increased rate of reduction of NAD+ to NADH. Several lines of evidence support the likelihood that the increased cytosolic ratio of free NADH/NAD+ caused by hyperglycemia, referred to as pseudohypoxia because tissue partial pressure oxygen is normal, is a characteristic feature of poorly controlled diabetes that mimics the effects of true hypoxia on vascular and neural function and plays an important role in the pathogenesis of diabetic complications. These effects of hypoxia and hyperglycemia-induced pseudohypoxia on vascular and neural function are mediated by a branching cascade of imbalances in lipid metabolism, increased production of superoxide anion, and possibly increased nitric oxide formation.

AB - Vasodilation and increased blood flow are characteristic early vascular responses to acute hyperglycemia and tissue hypoxia. In hypoxic tissues these vascular changes are linked to metabolic imbalances associated with impaired oxidation of NADH to NAD+ and the resulting increased ratio of NADH/NAD+. In hyperglycemic tissues these vascular changes also are linked to an increased ratio of NADH/NAD+, in this case because of an increased rate of reduction of NAD+ to NADH. Several lines of evidence support the likelihood that the increased cytosolic ratio of free NADH/NAD+ caused by hyperglycemia, referred to as pseudohypoxia because tissue partial pressure oxygen is normal, is a characteristic feature of poorly controlled diabetes that mimics the effects of true hypoxia on vascular and neural function and plays an important role in the pathogenesis of diabetic complications. These effects of hypoxia and hyperglycemia-induced pseudohypoxia on vascular and neural function are mediated by a branching cascade of imbalances in lipid metabolism, increased production of superoxide anion, and possibly increased nitric oxide formation.

UR - http://www.scopus.com/inward/record.url?scp=0027318772&partnerID=8YFLogxK

U2 - 10.2337/diab.42.6.801

DO - 10.2337/diab.42.6.801

M3 - Review

C2 - 8495803

AN - SCOPUS:0027318772

VL - 42

SP - 801

EP - 813

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 6

ER -