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Jens Randel Nyengaard

Heterogeneous downregulation of angiotensin II AT1-A and AT1-B receptors in arterioles in STZ-induced diabetic rat kidneys

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Heterogeneous downregulation of angiotensin II AT1-A and AT1-B receptors in arterioles in STZ-induced diabetic rat kidneys. / Razga, Zsolt; Kovacs, Gabor; Bódi, Nikolett; Talapka, Petra; Nyengaard, Jens Randel.

In: BioMed Research International, Vol. 2014, 947506, 2014.

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Razga, Zsolt ; Kovacs, Gabor ; Bódi, Nikolett ; Talapka, Petra ; Nyengaard, Jens Randel. / Heterogeneous downregulation of angiotensin II AT1-A and AT1-B receptors in arterioles in STZ-induced diabetic rat kidneys. In: BioMed Research International. 2014 ; Vol. 2014.

Bibtex

@article{656633d747dd441a8d81a1e69b4fb88e,
title = "Heterogeneous downregulation of angiotensin II AT1-A and AT1-B receptors in arterioles in STZ-induced diabetic rat kidneys",
abstract = "INTRODUCTION: The renin granulation of kidney arterioles is enhanced in diabetes despite the fact that the level of angiotensin II in the diabetic kidney is elevated. Therefore, the number of angiotensin II AT1-A and AT1-B receptors in afferent and efferent arteriole's renin-positive and renin-negative smooth muscle cells (SMC) was estimated.METHOD: Immunohistochemistry at the electron microscopic level was combined with 3D stereological sampling techniques.RESULTS: In diabetes the enhanced downregulation of AT1-B receptors in the renin-positive than in the renin-negative SMCs in both arterioles was resulted: the significant difference in the number of AT1 (AT1-A + AT1-B) receptors between the two types of SMCs in the normal rats was further increased in diabetes and in contrast with the significant difference observed between the afferent and efferent arterioles in the normal animals, there was no such difference in diabetes.CONCLUSIONS: The enhanced downregulation of the AT1-B receptors in the renin-negative SMCs in the efferent arterioles demonstrates that the regulation of the glomerular filtration rate by the pre- and postglomerular arterioles is changed in diabetes. The enhanced downregulation of the AT1-B receptors in the renin-positive SMCs in the arterioles may result in an enhanced level of renin granulation in the arterioles.",
author = "Zsolt Razga and Gabor Kovacs and Nikolett B{\'o}di and Petra Talapka and Nyengaard, {Jens Randel}",
year = "2014",
doi = "10.1155/2014/947506",
language = "English",
volume = "2014",
journal = "Journal of Biomedicine and Biotechnology",
issn = "1110-7243",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Heterogeneous downregulation of angiotensin II AT1-A and AT1-B receptors in arterioles in STZ-induced diabetic rat kidneys

AU - Razga, Zsolt

AU - Kovacs, Gabor

AU - Bódi, Nikolett

AU - Talapka, Petra

AU - Nyengaard, Jens Randel

PY - 2014

Y1 - 2014

N2 - INTRODUCTION: The renin granulation of kidney arterioles is enhanced in diabetes despite the fact that the level of angiotensin II in the diabetic kidney is elevated. Therefore, the number of angiotensin II AT1-A and AT1-B receptors in afferent and efferent arteriole's renin-positive and renin-negative smooth muscle cells (SMC) was estimated.METHOD: Immunohistochemistry at the electron microscopic level was combined with 3D stereological sampling techniques.RESULTS: In diabetes the enhanced downregulation of AT1-B receptors in the renin-positive than in the renin-negative SMCs in both arterioles was resulted: the significant difference in the number of AT1 (AT1-A + AT1-B) receptors between the two types of SMCs in the normal rats was further increased in diabetes and in contrast with the significant difference observed between the afferent and efferent arterioles in the normal animals, there was no such difference in diabetes.CONCLUSIONS: The enhanced downregulation of the AT1-B receptors in the renin-negative SMCs in the efferent arterioles demonstrates that the regulation of the glomerular filtration rate by the pre- and postglomerular arterioles is changed in diabetes. The enhanced downregulation of the AT1-B receptors in the renin-positive SMCs in the arterioles may result in an enhanced level of renin granulation in the arterioles.

AB - INTRODUCTION: The renin granulation of kidney arterioles is enhanced in diabetes despite the fact that the level of angiotensin II in the diabetic kidney is elevated. Therefore, the number of angiotensin II AT1-A and AT1-B receptors in afferent and efferent arteriole's renin-positive and renin-negative smooth muscle cells (SMC) was estimated.METHOD: Immunohistochemistry at the electron microscopic level was combined with 3D stereological sampling techniques.RESULTS: In diabetes the enhanced downregulation of AT1-B receptors in the renin-positive than in the renin-negative SMCs in both arterioles was resulted: the significant difference in the number of AT1 (AT1-A + AT1-B) receptors between the two types of SMCs in the normal rats was further increased in diabetes and in contrast with the significant difference observed between the afferent and efferent arterioles in the normal animals, there was no such difference in diabetes.CONCLUSIONS: The enhanced downregulation of the AT1-B receptors in the renin-negative SMCs in the efferent arterioles demonstrates that the regulation of the glomerular filtration rate by the pre- and postglomerular arterioles is changed in diabetes. The enhanced downregulation of the AT1-B receptors in the renin-positive SMCs in the arterioles may result in an enhanced level of renin granulation in the arterioles.

U2 - 10.1155/2014/947506

DO - 10.1155/2014/947506

M3 - Journal article

C2 - 24587998

VL - 2014

JO - Journal of Biomedicine and Biotechnology

JF - Journal of Biomedicine and Biotechnology

SN - 1110-7243

M1 - 947506

ER -