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Jens Randel Nyengaard

Glomerular number and size in relation to age, kidney weight, and body surface in normal man.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Stereological Research Laboratory
  • Institute of Clinical Medicine
  • The Department of Pathology - ÅKH
The number and size of glomeruli in normal, mature human kidneys were estimated by a direct and unbiased stereological method, the fractionator. The number was 617,000 on average, and the mean size 6.0 M microns3. Both glomerular number and size showed significant negative correlation to age and significant positive correlation to kidney weight. Apparently, humans loose glomeruli with age. Body surface area correlated positively to kidney weight and total glomerular volume but not to number of glomeruli. Body surface area correlates significantly with metabolic rate (Robertson and Reid, Lancet, 1: 940-943, 1952). Thus, intraspecies adaptation of kidney filtration capacity to the metabolic demand is performed by changing the size of glomeruli, i.e., the number of glomeruli in individuals of a given species is independent of the metabolic rate.
Original languageEnglish
JournalAnatomical Record
Volume232
Issue2
Pages (from-to)194-201
Number of pages7
ISSN1932-8486
DOIs
Publication statusPublished - 1992

    Research areas

  • Adolescent, Adult, Aged, Aged, 80 and over, Aging, Body Surface Area, Female, Glomerular Filtration Rate, Humans, Kidney Glomerulus, Male, Metabolic Clearance Rate, Middle Aged, Organ Size

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