Jens Randel Nyengaard

Expression of hypoxia-inducible factor-1α and hepatocyte growth factor in development of fibrosis in the transplanted kidney

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Expression of hypoxia-inducible factor-1α and hepatocyte growth factor in development of fibrosis in the transplanted kidney. / Kellenberger, Terese; Marcussen, Niels; Nyengaard, Jens Randel; Wogensen, Lise; Jespersen, Bente.

In: Transplant International, Vol. 28, No. 2, 27.10.2014, p. 180-190.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{041c8992a0da46039549cbeb7b2b16dd,
title = "Expression of hypoxia-inducible factor-1α and hepatocyte growth factor in development of fibrosis in the transplanted kidney",
abstract = "Late renal graft loss is associated with interstitial fibrosis. Hypoxia-inducible factor-1α (HIF-1α) is thought to facilitate fibrosis through interaction with TGF-β1, while hepatocyte growth factor (HGF) may act anti-fibrotic in the kidney allograft. The aim of this study was to investigate the expression of HIF-1α and HGF in protocol biopsies as possible prognostic biomarkers for renal fibrosis. Thirty-nine renal transplant recipients were included in the study. Protocol biopsies performed one and two years after transplantation were used for immunohistochemistry analysis. The correlation between HIF-1α/HGF and the Banff score was analysed. In addition, progression in renal fibrosis and graft survival among recipients with high or low expression of HIF-1α/HGF after transplantation was compared. There was no significant correlation between fibrosis and the HIF-1α expression one and two years after transplantation, but an inverse significant correlation between the HGF expression and the fibrosis score one year after transplantation was shown. Even when adjusting for HLA mismatches, there was a significant relationship between fibrosis and HGF expression. Graft survival was not significantly correlated to HIF-1α or HGF at one year, although the trend was towards better graft survival with high HGF. HGF may have anti-fibrotic effects in human renal transplants. (Central.Denmark.Region.Committee number: 1-10-72-318-13) This article is protected by copyright. All rights reserved.",
author = "Terese Kellenberger and Niels Marcussen and Nyengaard, {Jens Randel} and Lise Wogensen and Bente Jespersen",
note = "This article is protected by copyright. All rights reserved.",
year = "2014",
month = oct,
day = "27",
doi = "10.1111/tri.12475",
language = "English",
volume = "28",
pages = "180--190",
journal = "Transplant International",
issn = "0934-0874",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - Expression of hypoxia-inducible factor-1α and hepatocyte growth factor in development of fibrosis in the transplanted kidney

AU - Kellenberger, Terese

AU - Marcussen, Niels

AU - Nyengaard, Jens Randel

AU - Wogensen, Lise

AU - Jespersen, Bente

N1 - This article is protected by copyright. All rights reserved.

PY - 2014/10/27

Y1 - 2014/10/27

N2 - Late renal graft loss is associated with interstitial fibrosis. Hypoxia-inducible factor-1α (HIF-1α) is thought to facilitate fibrosis through interaction with TGF-β1, while hepatocyte growth factor (HGF) may act anti-fibrotic in the kidney allograft. The aim of this study was to investigate the expression of HIF-1α and HGF in protocol biopsies as possible prognostic biomarkers for renal fibrosis. Thirty-nine renal transplant recipients were included in the study. Protocol biopsies performed one and two years after transplantation were used for immunohistochemistry analysis. The correlation between HIF-1α/HGF and the Banff score was analysed. In addition, progression in renal fibrosis and graft survival among recipients with high or low expression of HIF-1α/HGF after transplantation was compared. There was no significant correlation between fibrosis and the HIF-1α expression one and two years after transplantation, but an inverse significant correlation between the HGF expression and the fibrosis score one year after transplantation was shown. Even when adjusting for HLA mismatches, there was a significant relationship between fibrosis and HGF expression. Graft survival was not significantly correlated to HIF-1α or HGF at one year, although the trend was towards better graft survival with high HGF. HGF may have anti-fibrotic effects in human renal transplants. (Central.Denmark.Region.Committee number: 1-10-72-318-13) This article is protected by copyright. All rights reserved.

AB - Late renal graft loss is associated with interstitial fibrosis. Hypoxia-inducible factor-1α (HIF-1α) is thought to facilitate fibrosis through interaction with TGF-β1, while hepatocyte growth factor (HGF) may act anti-fibrotic in the kidney allograft. The aim of this study was to investigate the expression of HIF-1α and HGF in protocol biopsies as possible prognostic biomarkers for renal fibrosis. Thirty-nine renal transplant recipients were included in the study. Protocol biopsies performed one and two years after transplantation were used for immunohistochemistry analysis. The correlation between HIF-1α/HGF and the Banff score was analysed. In addition, progression in renal fibrosis and graft survival among recipients with high or low expression of HIF-1α/HGF after transplantation was compared. There was no significant correlation between fibrosis and the HIF-1α expression one and two years after transplantation, but an inverse significant correlation between the HGF expression and the fibrosis score one year after transplantation was shown. Even when adjusting for HLA mismatches, there was a significant relationship between fibrosis and HGF expression. Graft survival was not significantly correlated to HIF-1α or HGF at one year, although the trend was towards better graft survival with high HGF. HGF may have anti-fibrotic effects in human renal transplants. (Central.Denmark.Region.Committee number: 1-10-72-318-13) This article is protected by copyright. All rights reserved.

U2 - 10.1111/tri.12475

DO - 10.1111/tri.12475

M3 - Journal article

C2 - 25284705

VL - 28

SP - 180

EP - 190

JO - Transplant International

JF - Transplant International

SN - 0934-0874

IS - 2

ER -