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Jens Randel Nyengaard

Dynamics of Cell Generation and Turnover in the Human Heart

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Dynamics of Cell Generation and Turnover in the Human Heart. / Bergmann, Olaf; Zdunek, Sofia; Felker, Anastasia; Salehpour, Mehran; Alkass, Kanar; Bernard, Samuel; Sjostrom, Staffan L; Szewczykowska, Mirosława; Jackowska, Teresa; Dos Remedios, Cris; Malm, Torsten; Andrä, Michaela; Jashari, Ramadan; Nyengaard, Jens R; Possnert, Göran; Jovinge, Stefan; Druid, Henrik; Frisén, Jonas.

In: Cell, Vol. 161, No. 7, 18.06.2015, p. 1566-75.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Bergmann, O, Zdunek, S, Felker, A, Salehpour, M, Alkass, K, Bernard, S, Sjostrom, SL, Szewczykowska, M, Jackowska, T, Dos Remedios, C, Malm, T, Andrä, M, Jashari, R, Nyengaard, JR, Possnert, G, Jovinge, S, Druid, H & Frisén, J 2015, 'Dynamics of Cell Generation and Turnover in the Human Heart', Cell, vol. 161, no. 7, pp. 1566-75. https://doi.org/10.1016/j.cell.2015.05.026

APA

Bergmann, O., Zdunek, S., Felker, A., Salehpour, M., Alkass, K., Bernard, S., Sjostrom, S. L., Szewczykowska, M., Jackowska, T., Dos Remedios, C., Malm, T., Andrä, M., Jashari, R., Nyengaard, J. R., Possnert, G., Jovinge, S., Druid, H., & Frisén, J. (2015). Dynamics of Cell Generation and Turnover in the Human Heart. Cell, 161(7), 1566-75. https://doi.org/10.1016/j.cell.2015.05.026

CBE

Bergmann O, Zdunek S, Felker A, Salehpour M, Alkass K, Bernard S, Sjostrom SL, Szewczykowska M, Jackowska T, Dos Remedios C, Malm T, Andrä M, Jashari R, Nyengaard JR, Possnert G, Jovinge S, Druid H, Frisén J. 2015. Dynamics of Cell Generation and Turnover in the Human Heart. Cell. 161(7):1566-75. https://doi.org/10.1016/j.cell.2015.05.026

MLA

Vancouver

Bergmann O, Zdunek S, Felker A, Salehpour M, Alkass K, Bernard S et al. Dynamics of Cell Generation and Turnover in the Human Heart. Cell. 2015 Jun 18;161(7):1566-75. https://doi.org/10.1016/j.cell.2015.05.026

Author

Bergmann, Olaf ; Zdunek, Sofia ; Felker, Anastasia ; Salehpour, Mehran ; Alkass, Kanar ; Bernard, Samuel ; Sjostrom, Staffan L ; Szewczykowska, Mirosława ; Jackowska, Teresa ; Dos Remedios, Cris ; Malm, Torsten ; Andrä, Michaela ; Jashari, Ramadan ; Nyengaard, Jens R ; Possnert, Göran ; Jovinge, Stefan ; Druid, Henrik ; Frisén, Jonas. / Dynamics of Cell Generation and Turnover in the Human Heart. In: Cell. 2015 ; Vol. 161, No. 7. pp. 1566-75.

Bibtex

@article{c0022211601444129bac6f83d7299473,
title = "Dynamics of Cell Generation and Turnover in the Human Heart",
abstract = "The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart.",
keywords = "Antigens, CD45, Endothelial Cells, Heart, Humans, Mesoderm, Myocardium, Myocytes, Cardiac, Polyploidy, Radiometric Dating",
author = "Olaf Bergmann and Sofia Zdunek and Anastasia Felker and Mehran Salehpour and Kanar Alkass and Samuel Bernard and Sjostrom, {Staffan L} and Miros{\l}awa Szewczykowska and Teresa Jackowska and {Dos Remedios}, Cris and Torsten Malm and Michaela Andr{\"a} and Ramadan Jashari and Nyengaard, {Jens R} and G{\"o}ran Possnert and Stefan Jovinge and Henrik Druid and Jonas Fris{\'e}n",
note = "Copyright {\textcopyright} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
month = jun,
day = "18",
doi = "10.1016/j.cell.2015.05.026",
language = "English",
volume = "161",
pages = "1566--75",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "7",

}

RIS

TY - JOUR

T1 - Dynamics of Cell Generation and Turnover in the Human Heart

AU - Bergmann, Olaf

AU - Zdunek, Sofia

AU - Felker, Anastasia

AU - Salehpour, Mehran

AU - Alkass, Kanar

AU - Bernard, Samuel

AU - Sjostrom, Staffan L

AU - Szewczykowska, Mirosława

AU - Jackowska, Teresa

AU - Dos Remedios, Cris

AU - Malm, Torsten

AU - Andrä, Michaela

AU - Jashari, Ramadan

AU - Nyengaard, Jens R

AU - Possnert, Göran

AU - Jovinge, Stefan

AU - Druid, Henrik

AU - Frisén, Jonas

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/6/18

Y1 - 2015/6/18

N2 - The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart.

AB - The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart.

KW - Antigens, CD45

KW - Endothelial Cells

KW - Heart

KW - Humans

KW - Mesoderm

KW - Myocardium

KW - Myocytes, Cardiac

KW - Polyploidy

KW - Radiometric Dating

U2 - 10.1016/j.cell.2015.05.026

DO - 10.1016/j.cell.2015.05.026

M3 - Journal article

C2 - 26073943

VL - 161

SP - 1566

EP - 1575

JO - Cell

JF - Cell

SN - 0092-8674

IS - 7

ER -