Jens Randel Nyengaard

Calcified cartilage in patients with osteoarthritis of the hip compared to that of healthy subjects. A design-based histological study

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Calcified cartilage in patients with osteoarthritis of the hip compared to that of healthy subjects. A design-based histological study. / Klose-Jensen, Rasmus; Hartlev, Louise Brøndt; Thomsen, Jesper Skovhus; Nyengaard, Jens Randel; Boel, Lene Warner Thorup; Laursen, Mogens; Laurberg, Trine Bay; Stengaard-Pedersen, Kristian; Hauge, Ellen Margrethe.

In: Bone, Vol. 143, 115660, 02.2021.

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@article{daa6c5f676f146138d624678a1b14e5a,
title = "Calcified cartilage in patients with osteoarthritis of the hip compared to that of healthy subjects. A design-based histological study",
abstract = "Objective: Calcified cartilage is suggested to be involved in the pathogenesis of osteoarthritis (OA) by facilitating endochondral ossification at the bone-cartilage unit. Therefore, the objective was to quantify the volume and surface area of the calcified cartilage in the femoral head in OA patients and healthy subjects. Materials and methods: We used design-based stereological principles, i.e., systematic uniform random sampling and vertical uniform random sections of the entire femoral head. We investigated the articular and calcified cartilage and femoral head surface area and volume, excluding fovea capitis and marginal osteophytes, in 20 patients with OA and 15 healthy subjects. Results: The volume of the calcified cartilage was significantly larger for the patients with OA compared with the healthy subjects (mean difference [95% CI]) (284 [110,457] mm3, p = 0.002). The upper and lower surface area of the calcified cartilage, i.e. the tidemark and cement line, were both significantly larger for OA patients compared with the healthy subjects (17.8 [8.4,27.3] cm2, p < 0.001) and (38.7 [20.8,56.7] cm2, p = 0.002), respectively. The volume of the calcified cartilage and the volume of the femoral head were significantly correlated for the patients with OA (Spearman's ρ = 0.51, p = 0.021), but not for the healthy subjects (ρ = 0.41, p = 0.123). Conclusions: Patients with OA had a larger femoral head surface area and more calcified cartilage compared to healthy subjects. The volume of the calcified cartilage correlated positively with the volume of the femoral head for patients with OA, but not for healthy subjects. This strongly supports the existing view that bone growth in OA is associated with endochondral ossification.",
keywords = "Calcified cartilage, Femur head, Histology, Human, Osteoarthritis, Stereology",
author = "Rasmus Klose-Jensen and Hartlev, {Louise Br{\o}ndt} and Thomsen, {Jesper Skovhus} and Nyengaard, {Jens Randel} and Boel, {Lene Warner Thorup} and Mogens Laursen and Laurberg, {Trine Bay} and Kristian Stengaard-Pedersen and Hauge, {Ellen Margrethe}",
year = "2021",
month = feb,
doi = "10.1016/j.bone.2020.115660",
language = "English",
volume = "143",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Calcified cartilage in patients with osteoarthritis of the hip compared to that of healthy subjects. A design-based histological study

AU - Klose-Jensen, Rasmus

AU - Hartlev, Louise Brøndt

AU - Thomsen, Jesper Skovhus

AU - Nyengaard, Jens Randel

AU - Boel, Lene Warner Thorup

AU - Laursen, Mogens

AU - Laurberg, Trine Bay

AU - Stengaard-Pedersen, Kristian

AU - Hauge, Ellen Margrethe

PY - 2021/2

Y1 - 2021/2

N2 - Objective: Calcified cartilage is suggested to be involved in the pathogenesis of osteoarthritis (OA) by facilitating endochondral ossification at the bone-cartilage unit. Therefore, the objective was to quantify the volume and surface area of the calcified cartilage in the femoral head in OA patients and healthy subjects. Materials and methods: We used design-based stereological principles, i.e., systematic uniform random sampling and vertical uniform random sections of the entire femoral head. We investigated the articular and calcified cartilage and femoral head surface area and volume, excluding fovea capitis and marginal osteophytes, in 20 patients with OA and 15 healthy subjects. Results: The volume of the calcified cartilage was significantly larger for the patients with OA compared with the healthy subjects (mean difference [95% CI]) (284 [110,457] mm3, p = 0.002). The upper and lower surface area of the calcified cartilage, i.e. the tidemark and cement line, were both significantly larger for OA patients compared with the healthy subjects (17.8 [8.4,27.3] cm2, p < 0.001) and (38.7 [20.8,56.7] cm2, p = 0.002), respectively. The volume of the calcified cartilage and the volume of the femoral head were significantly correlated for the patients with OA (Spearman's ρ = 0.51, p = 0.021), but not for the healthy subjects (ρ = 0.41, p = 0.123). Conclusions: Patients with OA had a larger femoral head surface area and more calcified cartilage compared to healthy subjects. The volume of the calcified cartilage correlated positively with the volume of the femoral head for patients with OA, but not for healthy subjects. This strongly supports the existing view that bone growth in OA is associated with endochondral ossification.

AB - Objective: Calcified cartilage is suggested to be involved in the pathogenesis of osteoarthritis (OA) by facilitating endochondral ossification at the bone-cartilage unit. Therefore, the objective was to quantify the volume and surface area of the calcified cartilage in the femoral head in OA patients and healthy subjects. Materials and methods: We used design-based stereological principles, i.e., systematic uniform random sampling and vertical uniform random sections of the entire femoral head. We investigated the articular and calcified cartilage and femoral head surface area and volume, excluding fovea capitis and marginal osteophytes, in 20 patients with OA and 15 healthy subjects. Results: The volume of the calcified cartilage was significantly larger for the patients with OA compared with the healthy subjects (mean difference [95% CI]) (284 [110,457] mm3, p = 0.002). The upper and lower surface area of the calcified cartilage, i.e. the tidemark and cement line, were both significantly larger for OA patients compared with the healthy subjects (17.8 [8.4,27.3] cm2, p < 0.001) and (38.7 [20.8,56.7] cm2, p = 0.002), respectively. The volume of the calcified cartilage and the volume of the femoral head were significantly correlated for the patients with OA (Spearman's ρ = 0.51, p = 0.021), but not for the healthy subjects (ρ = 0.41, p = 0.123). Conclusions: Patients with OA had a larger femoral head surface area and more calcified cartilage compared to healthy subjects. The volume of the calcified cartilage correlated positively with the volume of the femoral head for patients with OA, but not for healthy subjects. This strongly supports the existing view that bone growth in OA is associated with endochondral ossification.

KW - Calcified cartilage

KW - Femur head

KW - Histology

KW - Human

KW - Osteoarthritis

KW - Stereology

UR - http://www.scopus.com/inward/record.url?scp=85091787600&partnerID=8YFLogxK

U2 - 10.1016/j.bone.2020.115660

DO - 10.1016/j.bone.2020.115660

M3 - Journal article

C2 - 32979538

AN - SCOPUS:85091787600

VL - 143

JO - Bone

JF - Bone

SN - 8756-3282

M1 - 115660

ER -