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Jens Randel Nyengaard

A new model for fetal programming: maternal Ramadan-type fasting programs nephrogenesis

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A new model for fetal programming : maternal Ramadan-type fasting programs nephrogenesis. / Mohany, M.; Ashton, N.; Harrath, A. H.; Nyengaard, J. R.; Alomar, S. Y.; Alwasel, S.

In: Journal of Developmental Origins of Health and Disease, Vol. 9, No. 3, 2018, p. 287-298.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Mohany, M, Ashton, N, Harrath, AH, Nyengaard, JR, Alomar, SY & Alwasel, S 2018, 'A new model for fetal programming: maternal Ramadan-type fasting programs nephrogenesis', Journal of Developmental Origins of Health and Disease, vol. 9, no. 3, pp. 287-298. https://doi.org/10.1017/S204017441700109X

APA

Mohany, M., Ashton, N., Harrath, A. H., Nyengaard, J. R., Alomar, S. Y., & Alwasel, S. (2018). A new model for fetal programming: maternal Ramadan-type fasting programs nephrogenesis. Journal of Developmental Origins of Health and Disease, 9(3), 287-298. https://doi.org/10.1017/S204017441700109X

CBE

Mohany M, Ashton N, Harrath AH, Nyengaard JR, Alomar SY, Alwasel S. 2018. A new model for fetal programming: maternal Ramadan-type fasting programs nephrogenesis. Journal of Developmental Origins of Health and Disease. 9(3):287-298. https://doi.org/10.1017/S204017441700109X

MLA

Mohany, M. et al. "A new model for fetal programming: maternal Ramadan-type fasting programs nephrogenesis". Journal of Developmental Origins of Health and Disease. 2018, 9(3). 287-298. https://doi.org/10.1017/S204017441700109X

Vancouver

Mohany M, Ashton N, Harrath AH, Nyengaard JR, Alomar SY, Alwasel S. A new model for fetal programming: maternal Ramadan-type fasting programs nephrogenesis. Journal of Developmental Origins of Health and Disease. 2018;9(3):287-298. https://doi.org/10.1017/S204017441700109X

Author

Mohany, M. ; Ashton, N. ; Harrath, A. H. ; Nyengaard, J. R. ; Alomar, S. Y. ; Alwasel, S. / A new model for fetal programming : maternal Ramadan-type fasting programs nephrogenesis. In: Journal of Developmental Origins of Health and Disease. 2018 ; Vol. 9, No. 3. pp. 287-298.

Bibtex

@article{3d218bad4b32493a9140354d5ae1f81d,
title = "A new model for fetal programming: maternal Ramadan-type fasting programs nephrogenesis",
abstract = "The effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and water ad libitum during pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined during fetal life, at birth, and in early and late adulthood. Maternal body weight, food intake, relative food intake and plasma glucose levels were significantly lower (P<0.001) in the RTF group. Litter and pup weights also were significantly lower (P<0.05) in the RTF group at birth, with no difference in the litter size. The RTF group had a longer gestation, delayed nephrogenesis with less well-differentiated glomeruli, more connective tissue, fewer medullary rays, an increase in the nephrogenic zone/cortical zone ratio, and significant increase (P<0.001) in kidney apoptosis at birth. On the other hand, maternal fasting reduced nephron number (by ~31%) with unchanged kidney and total glomerular volumes. Mean glomerular volume was significantly higher in RTF offspring. Assessment of renal structure revealed mild glomerulosclerosis with enlarged lobulated glomeruli in the renal cortex and high interstitial fibrosis in the medulla of RTF kidneys. Taken together, gestational fasting delays nephrogenesis and reduces nephron number in the kidneys of the offspring, that could be partially owing to increased apoptosis.",
keywords = "apoptosis, fasting, nephrogenesis, pregnancy",
author = "M. Mohany and N. Ashton and Harrath, {A. H.} and Nyengaard, {J. R.} and Alomar, {S. Y.} and S. Alwasel",
year = "2018",
doi = "10.1017/S204017441700109X",
language = "English",
volume = "9",
pages = "287--298",
journal = "Journal of Developmental Origins of Health and Disease",
issn = "2040-1744",
publisher = "Cambridge University Press",
number = "3",

}

RIS

TY - JOUR

T1 - A new model for fetal programming

T2 - maternal Ramadan-type fasting programs nephrogenesis

AU - Mohany, M.

AU - Ashton, N.

AU - Harrath, A. H.

AU - Nyengaard, J. R.

AU - Alomar, S. Y.

AU - Alwasel, S.

PY - 2018

Y1 - 2018

N2 - The effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and water ad libitum during pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined during fetal life, at birth, and in early and late adulthood. Maternal body weight, food intake, relative food intake and plasma glucose levels were significantly lower (P<0.001) in the RTF group. Litter and pup weights also were significantly lower (P<0.05) in the RTF group at birth, with no difference in the litter size. The RTF group had a longer gestation, delayed nephrogenesis with less well-differentiated glomeruli, more connective tissue, fewer medullary rays, an increase in the nephrogenic zone/cortical zone ratio, and significant increase (P<0.001) in kidney apoptosis at birth. On the other hand, maternal fasting reduced nephron number (by ~31%) with unchanged kidney and total glomerular volumes. Mean glomerular volume was significantly higher in RTF offspring. Assessment of renal structure revealed mild glomerulosclerosis with enlarged lobulated glomeruli in the renal cortex and high interstitial fibrosis in the medulla of RTF kidneys. Taken together, gestational fasting delays nephrogenesis and reduces nephron number in the kidneys of the offspring, that could be partially owing to increased apoptosis.

AB - The effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and water ad libitum during pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined during fetal life, at birth, and in early and late adulthood. Maternal body weight, food intake, relative food intake and plasma glucose levels were significantly lower (P<0.001) in the RTF group. Litter and pup weights also were significantly lower (P<0.05) in the RTF group at birth, with no difference in the litter size. The RTF group had a longer gestation, delayed nephrogenesis with less well-differentiated glomeruli, more connective tissue, fewer medullary rays, an increase in the nephrogenic zone/cortical zone ratio, and significant increase (P<0.001) in kidney apoptosis at birth. On the other hand, maternal fasting reduced nephron number (by ~31%) with unchanged kidney and total glomerular volumes. Mean glomerular volume was significantly higher in RTF offspring. Assessment of renal structure revealed mild glomerulosclerosis with enlarged lobulated glomeruli in the renal cortex and high interstitial fibrosis in the medulla of RTF kidneys. Taken together, gestational fasting delays nephrogenesis and reduces nephron number in the kidneys of the offspring, that could be partially owing to increased apoptosis.

KW - apoptosis

KW - fasting

KW - nephrogenesis

KW - pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85040742430&partnerID=8YFLogxK

U2 - 10.1017/S204017441700109X

DO - 10.1017/S204017441700109X

M3 - Journal article

C2 - 29317010

AN - SCOPUS:85040742430

VL - 9

SP - 287

EP - 298

JO - Journal of Developmental Origins of Health and Disease

JF - Journal of Developmental Origins of Health and Disease

SN - 2040-1744

IS - 3

ER -