Jens Georg Leipziger

P2X receptors in epithelia

Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

P2X receptors are ubiquitously expressed in all epithelial tissues but their functional roles are less well studied. Here we review the current state of knowledge by focusing on functional effects of P2X receptor in secretory and in absorptive tissues. In glandular tissue like the parotid gland basolateral P2X receptors stimulate ion secretion via an increase of [Ca2+]i. In absorptive epithelia like the renal tubule P2X receptor stimulation mediates the inhibition of NaCl, Mg2+ and water transport in the thick ascending limb and the distal convoluted tubule, respectively. The underlying signaling pathways that inhibit epithelial absorption are currently not well understood. Epithelial P2X7 receptors show pronounced up-regulation during varies diseased states highlighting a role of purinergic signaling in epithelial pathophysiology. Importantly, functional effects of epithelial P2X receptors cover numerous other aspects ranging from modulation of sound transmission, activation of apoptosis or production of oxygen radicals. Eventually, P2X receptors in epithelia are an understudied issue offering numerous novel and very attractive questions.
Original languageEnglish
Title of host publicationIon Channels and Transporters of Epithelia in Health and Disease
EditorsKirk Hamilton, Brian Harvey, Dan Devor
Number of pages27
Publication year2015
Publication statusPublished - 2015

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