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Jens Christian Jensenius

Umbilical cord mannan-binding lectin and infections in early childhood

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  • Department of Medical Microbiology and Immunology
  • Perinatal epidemiologi, SKS
  • The Danish Epidemiology Science Centre
  • The Department of Paediatrics
To investigate whether mannan-binding lectin (MBL) in umbilical cord blood (UCB) is associated with the incidence rate of hospitalizations for infections during early childhood. A follow-up study from birth to 31 months of age, with endpoint data from the Danish National Hospital Discharge Registry. The concentration of MBL and immunoglobulin A (IgA) in UCB was measured in a time-resolved immunofluorometric assay. Information on possible confounding factors was obtained from questionnaires completed by mothers during their pregnancy, and characteristics of the child at birth were registered by a midwife on a structured coding sheet. A total of 2104 infants born in the period between 1 February 1990 and 25 May 1991 to mothers living in the municipality of Aarhus. Concentration of MBL and IgA in UCB, gestational age, birth weight, number of siblings less than 3 years old, mother's smoking habits, alcohol and coffee consumption, educational and marital status and previous spontaneous abortions and stillbirths. Of 2104 children, 626 were hospitalized at least once, and 346 of these were hospitalized with infection. The hazard ratio (HR) of hospitalization with infections in children with low levels of MBL (
Original languageEnglish
JournalScandinavian Journal of Immunology
Volume57
Issue2
Pages (from-to)167-72
Number of pages6
ISSN0300-9475
DOIs
Publication statusPublished - 2003

    Research areas

  • Adult, Birth Weight, Cohort Studies, Communicable Diseases, Denmark, Female, Fetal Blood, Follow-Up Studies, Gestational Age, Hospitalization, Humans, Immunoglobulin A, Incidence, Infant, Newborn, Mannose-Binding Lectin, Maternal Age, Pregnancy, Proportional Hazards Models, Questionnaires

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