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Jens Christian Jensenius

Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene

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Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene. / Stover, C M; Thiel, S; Thelen, M; Lynch, N J; Vorup-Jensen, T; Jensenius, Jens Christian; Schwaeble, W J.

In: Journal of Immunology, Vol. 162, No. 6, 1999, p. 3481-90.

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@article{d3fb7d8365c84436ba8498c2466ded50,
title = "Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene",
abstract = "Mannan-binding lectin (MBL) forms a multimolecular complex with at least two MBL-associated serine proteases, MASP-1 and MASP-2. This complex initiates the MBL pathway of complement activation by binding to carbohydrate structures present on bacteria, yeast, and viruses. MASP-1 and MASP-2 are composed of modular structural motifs similar to those of the C1q-associated serine proteases C1r and C1s. Another protein of 19 kDa with the same N-terminal sequence as the 76-kDa MASP-2 protein is consistently detected as part of the MBL/MASP complex. In this study, we present the primary structure of this novel MBL-associated plasma protein of 19 kDa, MAp19, and demonstrate that MAp19 and MASP-2 are encoded by two different mRNA species generated by alternative splicing/polyadenylation from one structural gene.",
keywords = "Alternative Splicing, Amino Acid Sequence, Animals, Base Sequence, Blood Proteins, Carrier Proteins, Collectins, Complement Activation, Exons, Genes, Humans, Introns, Lectins, Mannans, Mannose-Binding Protein-Associated Serine Proteases, Molecular Sequence Data, Molecular Weight, RNA, Messenger, Rats, Sequence Analysis, DNA, Serine Endopeptidases, Transcription, Genetic",
author = "Stover, {C M} and S Thiel and M Thelen and Lynch, {N J} and T Vorup-Jensen and Jensenius, {Jens Christian} and Schwaeble, {W J}",
year = "1999",
language = "English",
volume = "162",
pages = "3481--90",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "6",

}

RIS

TY - JOUR

T1 - Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene

AU - Stover, C M

AU - Thiel, S

AU - Thelen, M

AU - Lynch, N J

AU - Vorup-Jensen, T

AU - Jensenius, Jens Christian

AU - Schwaeble, W J

PY - 1999

Y1 - 1999

N2 - Mannan-binding lectin (MBL) forms a multimolecular complex with at least two MBL-associated serine proteases, MASP-1 and MASP-2. This complex initiates the MBL pathway of complement activation by binding to carbohydrate structures present on bacteria, yeast, and viruses. MASP-1 and MASP-2 are composed of modular structural motifs similar to those of the C1q-associated serine proteases C1r and C1s. Another protein of 19 kDa with the same N-terminal sequence as the 76-kDa MASP-2 protein is consistently detected as part of the MBL/MASP complex. In this study, we present the primary structure of this novel MBL-associated plasma protein of 19 kDa, MAp19, and demonstrate that MAp19 and MASP-2 are encoded by two different mRNA species generated by alternative splicing/polyadenylation from one structural gene.

AB - Mannan-binding lectin (MBL) forms a multimolecular complex with at least two MBL-associated serine proteases, MASP-1 and MASP-2. This complex initiates the MBL pathway of complement activation by binding to carbohydrate structures present on bacteria, yeast, and viruses. MASP-1 and MASP-2 are composed of modular structural motifs similar to those of the C1q-associated serine proteases C1r and C1s. Another protein of 19 kDa with the same N-terminal sequence as the 76-kDa MASP-2 protein is consistently detected as part of the MBL/MASP complex. In this study, we present the primary structure of this novel MBL-associated plasma protein of 19 kDa, MAp19, and demonstrate that MAp19 and MASP-2 are encoded by two different mRNA species generated by alternative splicing/polyadenylation from one structural gene.

KW - Alternative Splicing

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - Blood Proteins

KW - Carrier Proteins

KW - Collectins

KW - Complement Activation

KW - Exons

KW - Genes

KW - Humans

KW - Introns

KW - Lectins

KW - Mannans

KW - Mannose-Binding Protein-Associated Serine Proteases

KW - Molecular Sequence Data

KW - Molecular Weight

KW - RNA, Messenger

KW - Rats

KW - Sequence Analysis, DNA

KW - Serine Endopeptidases

KW - Transcription, Genetic

M3 - Journal article

C2 - 10092804

VL - 162

SP - 3481

EP - 3490

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 6

ER -