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Jens Christian Jensenius

The association between mannose-binding lectin gene polymorphism and rheumatic heart disease

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Mannan-binding lectin (MBL) is an innate pattern recognition molecule known to play a key role in pathogen clearance. As MBL2 gene polymorphism is associated to an increased susceptibility to infection, we aimed to determine genetic variations in the MBL2 gene in rheumatic heart disease (RHD). Genetic variations in the promoter and exon 1 region of the MBL2 gene were analyzed in 107 patients with RHD and 105 controls by real-time polymerase chain reaction. The frequency of MBL2* A/A genotype was significantly higher in RHD patients (71/107, 66.36% vs 52/105, 49.52%, p
Original languageEnglish
JournalHuman Immunology
Volume67
Issue12
Pages (from-to)991-8
Number of pages8
ISSN0198-8859
DOIs
Publication statusPublished - 2006

    Research areas

  • Adult, Aged, Case-Control Studies, Exons, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Humans, Male, Mannose-Binding Lectin, Middle Aged, Polymorphism, Genetic, Promoter Regions, Genetic, Rheumatic Heart Disease

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