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Jens Christian Jensenius

Susceptibility to Leprosy is Associated with M-ficolin Polymorphisms

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Angelica B W Boldt
  • ,
  • Maria Iolanda N Sanchez
  • ,
  • Ewalda R S Stahlke
  • ,
  • Rudi Steffensen, Aalborg University Hospital, Aalborg, Denmark., Denmark
  • Steffen Thiel
  • Jens C Jensenius
  • Flávia Costa Prevedello
  • ,
  • Marcelo Távora Mira
  • ,
  • Jürgen F J Kun
  • ,
  • Iara J T Messias-Reason
Mycobacterium leprae exploits complement activation and opsonophagocytosis to infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on monocyte surfaces. We investigated FCN1 promoter polymorphisms that could be responsible for the high interindividual variability of M-ficolin levels and for modulating leprosy susceptibility.
Original languageEnglish
JournalJournal of Clinical Immunology
Volume33
Issue1
Pages (from-to)210-9
Number of pages10
ISSN0271-9142
DOIs
Publication statusPublished - 2013

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