Aarhus University Seal / Aarhus Universitets segl

Jens Christian Jensenius

Susceptibility to Leprosy is Associated with M-ficolin Polymorphisms

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Angelica B W Boldt
  • ,
  • Maria Iolanda N Sanchez
  • ,
  • Ewalda R S Stahlke
  • ,
  • Rudi Steffensen, Aalborg University, Denmark
  • Steffen Thiel
  • Jens C Jensenius
  • Flávia Costa Prevedello
  • ,
  • Marcelo Távora Mira
  • ,
  • Jürgen F J Kun
  • ,
  • Iara J T Messias-Reason
Mycobacterium leprae exploits complement activation and opsonophagocytosis to infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on monocyte surfaces. We investigated FCN1 promoter polymorphisms that could be responsible for the high interindividual variability of M-ficolin levels and for modulating leprosy susceptibility.
Original languageEnglish
JournalJournal of Clinical Immunology
Pages (from-to)210-9
Number of pages10
Publication statusPublished - 2013

See relations at Aarhus University Citationformats

ID: 52459615