Jens Christian Jensenius

Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis. / Sokołowska, Anna; Świerzko, Anna S; Szala-Poździej, Agnieszka; Augustynowicz-Kopeć, Ewa; Kozińska, Monika; Niemiec, Tomasz; Błachnio, Maria; Borkowska-Tatar, Dagmara; Jensenius, Jens C; Thiel, Steffen; Dziadek, Jarosław; Cedzyński, Maciej.

In: Immunobiology, Vol. 225, No. 3, 151905, 05.2020, p. 151905.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Sokołowska, A, Świerzko, AS, Szala-Poździej, A, Augustynowicz-Kopeć, E, Kozińska, M, Niemiec, T, Błachnio, M, Borkowska-Tatar, D, Jensenius, JC, Thiel, S, Dziadek, J & Cedzyński, M 2020, 'Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis', Immunobiology, vol. 225, no. 3, 151905, pp. 151905. https://doi.org/10.1016/j.imbio.2020.151905

APA

Sokołowska, A., Świerzko, A. S., Szala-Poździej, A., Augustynowicz-Kopeć, E., Kozińska, M., Niemiec, T., Błachnio, M., Borkowska-Tatar, D., Jensenius, J. C., Thiel, S., Dziadek, J., & Cedzyński, M. (2020). Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis. Immunobiology, 225(3), 151905. [151905]. https://doi.org/10.1016/j.imbio.2020.151905

CBE

Sokołowska A, Świerzko AS, Szala-Poździej A, Augustynowicz-Kopeć E, Kozińska M, Niemiec T, Błachnio M, Borkowska-Tatar D, Jensenius JC, Thiel S, Dziadek J, Cedzyński M. 2020. Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis. Immunobiology. 225(3):151905. https://doi.org/10.1016/j.imbio.2020.151905

MLA

Vancouver

Sokołowska A, Świerzko AS, Szala-Poździej A, Augustynowicz-Kopeć E, Kozińska M, Niemiec T et al. Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis. Immunobiology. 2020 May;225(3):151905. 151905. https://doi.org/10.1016/j.imbio.2020.151905

Author

Sokołowska, Anna ; Świerzko, Anna S ; Szala-Poździej, Agnieszka ; Augustynowicz-Kopeć, Ewa ; Kozińska, Monika ; Niemiec, Tomasz ; Błachnio, Maria ; Borkowska-Tatar, Dagmara ; Jensenius, Jens C ; Thiel, Steffen ; Dziadek, Jarosław ; Cedzyński, Maciej. / Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis. In: Immunobiology. 2020 ; Vol. 225, No. 3. pp. 151905.

Bibtex

@article{46f95c898a464a06898aa910ea5835eb,
title = "Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis",
abstract = "We conducted a prospective study of 453 Polish patients suffering from pulmonary tuberculosis and 267 healthy controls. Selected polymorphisms of the genes encoding for collectins, ficolins and MBL-associated serine protease 2 were investigated as were serum concentrations of mannose-binding lectin, surfactant protein D, ficolin-1 and ficolin-3. The number of MBL2 gene exon 1 variant allele carriers was significantly higher in patients, compared with controls. The homozygosity for SFTPA2 +26 C > A SNP variant allele occurred less commonly within TB, while homozygosity for the FCN1 -542 G > A major allele was less frequent within the control group. Two patients were found MASP-2-deficient. Serum concentrations of MBL, SP-D and ficolin-1 were higher amongst patients while the converse was found for ficolin-3. Ficolin-1 had high specificity to differentiate between individuals with tuberculosis and healthy persons and therefore may be considered potential disease marker.",
keywords = "Collectin, Ficolin, MASP, Pulmonary surfactant, Tuberculosis",
author = "Anna Soko{\l}owska and {\'S}wierzko, {Anna S} and Agnieszka Szala-Po{\'z}dziej and Ewa Augustynowicz-Kope{\'c} and Monika Kozi{\'n}ska and Tomasz Niemiec and Maria B{\l}achnio and Dagmara Borkowska-Tatar and Jensenius, {Jens C} and Steffen Thiel and Jaros{\l}aw Dziadek and Maciej Cedzy{\'n}ski",
note = "Copyright {\textcopyright} 2020 Elsevier GmbH. All rights reserved.",
year = "2020",
month = may,
doi = "10.1016/j.imbio.2020.151905",
language = "English",
volume = "225",
pages = "151905",
journal = "Immunobiology",
issn = "0171-2985",
publisher = "Elsevier GmbH - Urban und Fischer",
number = "3",

}

RIS

TY - JOUR

T1 - Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis

AU - Sokołowska, Anna

AU - Świerzko, Anna S

AU - Szala-Poździej, Agnieszka

AU - Augustynowicz-Kopeć, Ewa

AU - Kozińska, Monika

AU - Niemiec, Tomasz

AU - Błachnio, Maria

AU - Borkowska-Tatar, Dagmara

AU - Jensenius, Jens C

AU - Thiel, Steffen

AU - Dziadek, Jarosław

AU - Cedzyński, Maciej

N1 - Copyright © 2020 Elsevier GmbH. All rights reserved.

PY - 2020/5

Y1 - 2020/5

N2 - We conducted a prospective study of 453 Polish patients suffering from pulmonary tuberculosis and 267 healthy controls. Selected polymorphisms of the genes encoding for collectins, ficolins and MBL-associated serine protease 2 were investigated as were serum concentrations of mannose-binding lectin, surfactant protein D, ficolin-1 and ficolin-3. The number of MBL2 gene exon 1 variant allele carriers was significantly higher in patients, compared with controls. The homozygosity for SFTPA2 +26 C > A SNP variant allele occurred less commonly within TB, while homozygosity for the FCN1 -542 G > A major allele was less frequent within the control group. Two patients were found MASP-2-deficient. Serum concentrations of MBL, SP-D and ficolin-1 were higher amongst patients while the converse was found for ficolin-3. Ficolin-1 had high specificity to differentiate between individuals with tuberculosis and healthy persons and therefore may be considered potential disease marker.

AB - We conducted a prospective study of 453 Polish patients suffering from pulmonary tuberculosis and 267 healthy controls. Selected polymorphisms of the genes encoding for collectins, ficolins and MBL-associated serine protease 2 were investigated as were serum concentrations of mannose-binding lectin, surfactant protein D, ficolin-1 and ficolin-3. The number of MBL2 gene exon 1 variant allele carriers was significantly higher in patients, compared with controls. The homozygosity for SFTPA2 +26 C > A SNP variant allele occurred less commonly within TB, while homozygosity for the FCN1 -542 G > A major allele was less frequent within the control group. Two patients were found MASP-2-deficient. Serum concentrations of MBL, SP-D and ficolin-1 were higher amongst patients while the converse was found for ficolin-3. Ficolin-1 had high specificity to differentiate between individuals with tuberculosis and healthy persons and therefore may be considered potential disease marker.

KW - Collectin

KW - Ficolin

KW - MASP

KW - Pulmonary surfactant

KW - Tuberculosis

U2 - 10.1016/j.imbio.2020.151905

DO - 10.1016/j.imbio.2020.151905

M3 - Journal article

C2 - 32007302

VL - 225

SP - 151905

JO - Immunobiology

JF - Immunobiology

SN - 0171-2985

IS - 3

M1 - 151905

ER -