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Jens Christian Jensenius

Reduced complement-mediated immune complex solubilizing capacity and the presence of incompletely solubilized immune complexes in SLE sera

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Reduced complement-mediated immune complex solubilizing capacity and the presence of incompletely solubilized immune complexes in SLE sera. / Baatrup, G; Petersen, I; Jensenius, Jens Christian; Svehag, S E.

In: Clinical and Experimental Immunology, Vol. 54, No. 2, 1983, p. 439-47.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Baatrup, G, Petersen, I, Jensenius, JC & Svehag, SE 1983, 'Reduced complement-mediated immune complex solubilizing capacity and the presence of incompletely solubilized immune complexes in SLE sera', Clinical and Experimental Immunology, vol. 54, no. 2, pp. 439-47.

APA

Baatrup, G., Petersen, I., Jensenius, J. C., & Svehag, S. E. (1983). Reduced complement-mediated immune complex solubilizing capacity and the presence of incompletely solubilized immune complexes in SLE sera. Clinical and Experimental Immunology, 54(2), 439-47.

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MLA

Vancouver

Author

Baatrup, G ; Petersen, I ; Jensenius, Jens Christian ; Svehag, S E. / Reduced complement-mediated immune complex solubilizing capacity and the presence of incompletely solubilized immune complexes in SLE sera. In: Clinical and Experimental Immunology. 1983 ; Vol. 54, No. 2. pp. 439-47.

Bibtex

@article{b669166b97f2443bb16d661975d591ad,
title = "Reduced complement-mediated immune complex solubilizing capacity and the presence of incompletely solubilized immune complexes in SLE sera",
abstract = "Reduced complement-mediated solubilization (CMS) of pre-formed immune complexes (IC) was demonstrated in sera from 11 out of 12 SLE patients. The presence of incompletely solubilized endogeneous IC in SLE sera was indicated by the following findings: (1) When IC positive SLE sera with reduced CMS capacity were mixed with normal donor sera they inhibited the CMS of the latter sera. (2) Resuspended PEG (2.75{\%}) precipitates obtained from SLE sera inhibited the CMS of normal donor sera. (3) Non-solubilized or incompletely complement solubilized IC in SLE sera give a strong response in the PEG-CC assay for IC. The IC activity of SLE sera was clearly reduced in this assay when the endogeneous IC were solubilized prior to testing. In contrast, sera of 14 rheumatoid arthritis (RA) patients exhibited normal CMS. IC which could be further solubilized by complement were not demonstrable although all RA sera were IC positive.",
keywords = "Adult, Aged, Antigen-Antibody Complex, Arthritis, Rheumatoid, Chromatography, Gel, Complement Fixation Tests, Complement System Proteins, Female, Humans, Immunoglobulin G, Lupus Erythematosus, Systemic, Male, Middle Aged, Polyethylene Glycols, Precipitin Tests, Solubility",
author = "G Baatrup and I Petersen and Jensenius, {Jens Christian} and Svehag, {S E}",
year = "1983",
language = "English",
volume = "54",
pages = "439--47",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - Reduced complement-mediated immune complex solubilizing capacity and the presence of incompletely solubilized immune complexes in SLE sera

AU - Baatrup, G

AU - Petersen, I

AU - Jensenius, Jens Christian

AU - Svehag, S E

PY - 1983

Y1 - 1983

N2 - Reduced complement-mediated solubilization (CMS) of pre-formed immune complexes (IC) was demonstrated in sera from 11 out of 12 SLE patients. The presence of incompletely solubilized endogeneous IC in SLE sera was indicated by the following findings: (1) When IC positive SLE sera with reduced CMS capacity were mixed with normal donor sera they inhibited the CMS of the latter sera. (2) Resuspended PEG (2.75%) precipitates obtained from SLE sera inhibited the CMS of normal donor sera. (3) Non-solubilized or incompletely complement solubilized IC in SLE sera give a strong response in the PEG-CC assay for IC. The IC activity of SLE sera was clearly reduced in this assay when the endogeneous IC were solubilized prior to testing. In contrast, sera of 14 rheumatoid arthritis (RA) patients exhibited normal CMS. IC which could be further solubilized by complement were not demonstrable although all RA sera were IC positive.

AB - Reduced complement-mediated solubilization (CMS) of pre-formed immune complexes (IC) was demonstrated in sera from 11 out of 12 SLE patients. The presence of incompletely solubilized endogeneous IC in SLE sera was indicated by the following findings: (1) When IC positive SLE sera with reduced CMS capacity were mixed with normal donor sera they inhibited the CMS of the latter sera. (2) Resuspended PEG (2.75%) precipitates obtained from SLE sera inhibited the CMS of normal donor sera. (3) Non-solubilized or incompletely complement solubilized IC in SLE sera give a strong response in the PEG-CC assay for IC. The IC activity of SLE sera was clearly reduced in this assay when the endogeneous IC were solubilized prior to testing. In contrast, sera of 14 rheumatoid arthritis (RA) patients exhibited normal CMS. IC which could be further solubilized by complement were not demonstrable although all RA sera were IC positive.

KW - Adult

KW - Aged

KW - Antigen-Antibody Complex

KW - Arthritis, Rheumatoid

KW - Chromatography, Gel

KW - Complement Fixation Tests

KW - Complement System Proteins

KW - Female

KW - Humans

KW - Immunoglobulin G

KW - Lupus Erythematosus, Systemic

KW - Male

KW - Middle Aged

KW - Polyethylene Glycols

KW - Precipitin Tests

KW - Solubility

M3 - Journal article

C2 - 6652967

VL - 54

SP - 439

EP - 447

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 2

ER -