Jens Christian Jensenius

Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings. / Hoffmann, Hans Jürgen; Iversen, Martin; Brandslund, Ivan; Sigsgaard, Torben; Omland, Øyvind; Oxvig, Claus; Holmskov, Uffe; Bjermer, Leif; Jensenius, Jens Christian; Dahl, Ronald.

In: Annals of Agricultural and Environmental Medicine, Vol. 10, No. 1, 2003, p. 53-60.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Hoffmann, HJ, Iversen, M, Brandslund, I, Sigsgaard, T, Omland, Ø, Oxvig, C, Holmskov, U, Bjermer, L, Jensenius, JC & Dahl, R 2003, 'Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings', Annals of Agricultural and Environmental Medicine, vol. 10, no. 1, pp. 53-60.

APA

Hoffmann, H. J., Iversen, M., Brandslund, I., Sigsgaard, T., Omland, Ø., Oxvig, C., Holmskov, U., Bjermer, L., Jensenius, J. C., & Dahl, R. (2003). Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings. Annals of Agricultural and Environmental Medicine, 10(1), 53-60.

CBE

Hoffmann HJ, Iversen M, Brandslund I, Sigsgaard T, Omland Ø, Oxvig C, Holmskov U, Bjermer L, Jensenius JC, Dahl R. 2003. Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings. Annals of Agricultural and Environmental Medicine. 10(1):53-60.

MLA

Vancouver

Hoffmann HJ, Iversen M, Brandslund I, Sigsgaard T, Omland Ø, Oxvig C et al. Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings. Annals of Agricultural and Environmental Medicine. 2003;10(1):53-60.

Author

Hoffmann, Hans Jürgen ; Iversen, Martin ; Brandslund, Ivan ; Sigsgaard, Torben ; Omland, Øyvind ; Oxvig, Claus ; Holmskov, Uffe ; Bjermer, Leif ; Jensenius, Jens Christian ; Dahl, Ronald. / Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings. In: Annals of Agricultural and Environmental Medicine. 2003 ; Vol. 10, No. 1. pp. 53-60.

Bibtex

@article{953720e0af6511df8c1a000ea68e967b,
title = "Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings",
abstract = "Work in swine confinement buildings leads to an inflammatory response and may be associated with increased levels of acute phase proteins. We compared the inflammatory response of a control group of young former farm workers with age-matched former farm workers who had previously developed the lower airway symptoms of wheeze, cough, tightness of the chest during work in swine confinement buildings, and because of these symptoms had stopped work. Both groups were subjected to an experimental exposure in a swine confinement building for 3 hours. Complement activation and acute phase proteins were measured in blood samples and broncho-alveolar lavage. Plasma C3d levels correlated with respirable dust, significantly so for individual cases and for the whole cohort. Plasma C3, fibrinogen and alpha (1) -acid glycoprotein peaked 1 and 6 h after exposure start, mannan-binding lectin, C-reactive protein and alpha(1)-antitrypsin peaked after 2 h. Surfactant protein D (SP-D) and alpha (2) -macroglobulin were downregulated. In lavage, only SP-D, alpha (2)-macroglobulin and fibronectin were detected. FEV(1), FVC, TLC and FEV(25-75) did not vary during exposure. There was complement activation in response to respiratory dust, more so amongst cases than in the control group. Acute exposure, with work related levels of organic dust containing endotoxin, leads to a weak systemic inflammatory response.",
keywords = "Adult, Age Factors, Air Pollution, Indoor, Animals, Case-Control Studies, Complement C3d, Dust, Humans, Inflammation, Inhalation Exposure, Lipopolysaccharides, Male, Occupational Exposure, Respiratory Tract Diseases, Swine",
author = "Hoffmann, {Hans J{\"u}rgen} and Martin Iversen and Ivan Brandslund and Torben Sigsgaard and {\O}yvind Omland and Claus Oxvig and Uffe Holmskov and Leif Bjermer and Jensenius, {Jens Christian} and Ronald Dahl",
year = "2003",
language = "English",
volume = "10",
pages = "53--60",
journal = "Annals of Agricultural and Environmental Medicine",
issn = "1232-1966",
publisher = "Institute of Rural Health in Lublin, Poland",
number = "1",

}

RIS

TY - JOUR

T1 - Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings

AU - Hoffmann, Hans Jürgen

AU - Iversen, Martin

AU - Brandslund, Ivan

AU - Sigsgaard, Torben

AU - Omland, Øyvind

AU - Oxvig, Claus

AU - Holmskov, Uffe

AU - Bjermer, Leif

AU - Jensenius, Jens Christian

AU - Dahl, Ronald

PY - 2003

Y1 - 2003

N2 - Work in swine confinement buildings leads to an inflammatory response and may be associated with increased levels of acute phase proteins. We compared the inflammatory response of a control group of young former farm workers with age-matched former farm workers who had previously developed the lower airway symptoms of wheeze, cough, tightness of the chest during work in swine confinement buildings, and because of these symptoms had stopped work. Both groups were subjected to an experimental exposure in a swine confinement building for 3 hours. Complement activation and acute phase proteins were measured in blood samples and broncho-alveolar lavage. Plasma C3d levels correlated with respirable dust, significantly so for individual cases and for the whole cohort. Plasma C3, fibrinogen and alpha (1) -acid glycoprotein peaked 1 and 6 h after exposure start, mannan-binding lectin, C-reactive protein and alpha(1)-antitrypsin peaked after 2 h. Surfactant protein D (SP-D) and alpha (2) -macroglobulin were downregulated. In lavage, only SP-D, alpha (2)-macroglobulin and fibronectin were detected. FEV(1), FVC, TLC and FEV(25-75) did not vary during exposure. There was complement activation in response to respiratory dust, more so amongst cases than in the control group. Acute exposure, with work related levels of organic dust containing endotoxin, leads to a weak systemic inflammatory response.

AB - Work in swine confinement buildings leads to an inflammatory response and may be associated with increased levels of acute phase proteins. We compared the inflammatory response of a control group of young former farm workers with age-matched former farm workers who had previously developed the lower airway symptoms of wheeze, cough, tightness of the chest during work in swine confinement buildings, and because of these symptoms had stopped work. Both groups were subjected to an experimental exposure in a swine confinement building for 3 hours. Complement activation and acute phase proteins were measured in blood samples and broncho-alveolar lavage. Plasma C3d levels correlated with respirable dust, significantly so for individual cases and for the whole cohort. Plasma C3, fibrinogen and alpha (1) -acid glycoprotein peaked 1 and 6 h after exposure start, mannan-binding lectin, C-reactive protein and alpha(1)-antitrypsin peaked after 2 h. Surfactant protein D (SP-D) and alpha (2) -macroglobulin were downregulated. In lavage, only SP-D, alpha (2)-macroglobulin and fibronectin were detected. FEV(1), FVC, TLC and FEV(25-75) did not vary during exposure. There was complement activation in response to respiratory dust, more so amongst cases than in the control group. Acute exposure, with work related levels of organic dust containing endotoxin, leads to a weak systemic inflammatory response.

KW - Adult

KW - Age Factors

KW - Air Pollution, Indoor

KW - Animals

KW - Case-Control Studies

KW - Complement C3d

KW - Dust

KW - Humans

KW - Inflammation

KW - Inhalation Exposure

KW - Lipopolysaccharides

KW - Male

KW - Occupational Exposure

KW - Respiratory Tract Diseases

KW - Swine

M3 - Journal article

C2 - 12852733

VL - 10

SP - 53

EP - 60

JO - Annals of Agricultural and Environmental Medicine

JF - Annals of Agricultural and Environmental Medicine

SN - 1232-1966

IS - 1

ER -