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Jens Christian Jensenius

Ontogeny of human mannan-binding protein, a lectin of the innate immune system

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  • Department of Medical Microbiology and Immunology
Mannan-binding protein (MBP) is a member of the collectins. These lectins are composed of polypeptide chains which contains a collagen-like region and a calcium dependent carbohydrate recognition domain (named a C-type CRD). MBP binds via the CRD to carbohydrate structures on microorganisms. MBP can activate the complement system when bound to carbohydrate. MBP is thus thought to play a role in the defence against microorganisms. The present report describes the ontogeny of MBP. The level of MBP increase during the first 3 months of life, at which time a stable level is reached, comparable to that seen in adults. On average, the level of MBP at term was 37% of the post 3-month level. Measurements on infants born prematurely showed a 3-fold increase in MBP concentration from the time of birth at around 30 weeks from conception to the 10th week of life.
Original languageEnglish
JournalPediatric Allergy and Immunology
Volume6
Issue1
Pages (from-to)20-3
Number of pages4
ISSN0905-6157
Publication statusPublished - 1 Feb 1995

    Research areas

  • Carrier Proteins, Collectins, Fetal Blood, Humans, Immunity, Maternally-Acquired, Infant, Lectins, Mannans

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