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Jens Christian Jensenius

Ontogeny of human mannan-binding protein, a lectin of the innate immune system

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  • Department of Medical Microbiology and Immunology
Mannan-binding protein (MBP) is a member of the collectins. These lectins are composed of polypeptide chains which contains a collagen-like region and a calcium dependent carbohydrate recognition domain (named a C-type CRD). MBP binds via the CRD to carbohydrate structures on microorganisms. MBP can activate the complement system when bound to carbohydrate. MBP is thus thought to play a role in the defence against microorganisms. The present report describes the ontogeny of MBP. The level of MBP increase during the first 3 months of life, at which time a stable level is reached, comparable to that seen in adults. On average, the level of MBP at term was 37% of the post 3-month level. Measurements on infants born prematurely showed a 3-fold increase in MBP concentration from the time of birth at around 30 weeks from conception to the 10th week of life.
Original languageEnglish
JournalPediatric Allergy and Immunology
Pages (from-to)20-3
Number of pages4
Publication statusPublished - 1 Feb 1995

    Research areas

  • Carrier Proteins, Collectins, Fetal Blood, Humans, Immunity, Maternally-Acquired, Infant, Lectins, Mannans

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