Jens Christian Jensenius

Non-Synonymous Polymorphisms in the FCN1 Gene Determine Ligand-Binding Ability and Serum Levels of M-Ficolin

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Non-Synonymous Polymorphisms in the FCN1 Gene Determine Ligand-Binding Ability and Serum Levels of M-Ficolin. / Ammitzbøll, Christian Gytz; Kjær, Troels Rønn; Steffensen, Rudi; Stengaard-Pedersen, Kristian; Nielsen, Hans Jørgen; Thiel, Steffen; Bøgsted, Martin; Jensenius, Jens Christian.

In: P L o S One, Vol. 7, No. 11, 2012, p. e50585.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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@article{5ea40c3e4ba94337a988115245bca98e,
title = "Non-Synonymous Polymorphisms in the FCN1 Gene Determine Ligand-Binding Ability and Serum Levels of M-Ficolin",
abstract = "The innate immune system encompasses various recognition molecules able to sense both exogenous and endogenous danger signals arising from pathogens or damaged host cells. One such pattern-recognition molecule is M-ficolin, which is capable of activating the complement system through the lectin pathway. The lectin pathway is multifaceted with activities spanning from complement activation to coagulation, autoimmunity, ischemia-reperfusion injury and embryogenesis. Our aim was to explore associations between SNPs in FCN1, encoding M-ficolin and corresponding protein concentrations, and the impact of non-synonymous SNPs on protein function.",
author = "Ammitzb{\o}ll, {Christian Gytz} and Kj{\ae}r, {Troels R{\o}nn} and Rudi Steffensen and Kristian Stengaard-Pedersen and Nielsen, {Hans J{\o}rgen} and Steffen Thiel and Martin B{\o}gsted and Jensenius, {Jens Christian}",
year = "2012",
doi = "10.1371/journal.pone.0050585",
language = "English",
volume = "7",
pages = "e50585",
journal = "P L o S One",
issn = "1932-6203",
publisher = "public library of science",
number = "11",

}

RIS

TY - JOUR

T1 - Non-Synonymous Polymorphisms in the FCN1 Gene Determine Ligand-Binding Ability and Serum Levels of M-Ficolin

AU - Ammitzbøll, Christian Gytz

AU - Kjær, Troels Rønn

AU - Steffensen, Rudi

AU - Stengaard-Pedersen, Kristian

AU - Nielsen, Hans Jørgen

AU - Thiel, Steffen

AU - Bøgsted, Martin

AU - Jensenius, Jens Christian

PY - 2012

Y1 - 2012

N2 - The innate immune system encompasses various recognition molecules able to sense both exogenous and endogenous danger signals arising from pathogens or damaged host cells. One such pattern-recognition molecule is M-ficolin, which is capable of activating the complement system through the lectin pathway. The lectin pathway is multifaceted with activities spanning from complement activation to coagulation, autoimmunity, ischemia-reperfusion injury and embryogenesis. Our aim was to explore associations between SNPs in FCN1, encoding M-ficolin and corresponding protein concentrations, and the impact of non-synonymous SNPs on protein function.

AB - The innate immune system encompasses various recognition molecules able to sense both exogenous and endogenous danger signals arising from pathogens or damaged host cells. One such pattern-recognition molecule is M-ficolin, which is capable of activating the complement system through the lectin pathway. The lectin pathway is multifaceted with activities spanning from complement activation to coagulation, autoimmunity, ischemia-reperfusion injury and embryogenesis. Our aim was to explore associations between SNPs in FCN1, encoding M-ficolin and corresponding protein concentrations, and the impact of non-synonymous SNPs on protein function.

U2 - 10.1371/journal.pone.0050585

DO - 10.1371/journal.pone.0050585

M3 - Journal article

C2 - 23209787

VL - 7

SP - e50585

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 11

ER -