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Jens Christian Jensenius

Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes

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Standard

Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes. / Johnstone, A P; Jensenius, Jens Christian; Millard, R E; Hudson, L.

In: Clinical and Experimental Immunology, Vol. 47, No. 3, 1982, p. 697-705.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Johnstone, AP, Jensenius, JC, Millard, RE & Hudson, L 1982, 'Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes', Clinical and Experimental Immunology, vol. 47, no. 3, pp. 697-705.

APA

Johnstone, A. P., Jensenius, J. C., Millard, R. E., & Hudson, L. (1982). Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes. Clinical and Experimental Immunology, 47(3), 697-705.

CBE

Johnstone AP, Jensenius JC, Millard RE, Hudson L. 1982. Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes. Clinical and Experimental Immunology. 47(3):697-705.

MLA

Johnstone, A P et al. "Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes". Clinical and Experimental Immunology. 1982, 47(3). 697-705.

Vancouver

Johnstone AP, Jensenius JC, Millard RE, Hudson L. Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes. Clinical and Experimental Immunology. 1982;47(3):697-705.

Author

Johnstone, A P ; Jensenius, Jens Christian ; Millard, R E ; Hudson, L. / Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes. In: Clinical and Experimental Immunology. 1982 ; Vol. 47, No. 3. pp. 697-705.

Bibtex

@article{ecfaedf1d857436095f2b178c7626e18,
title = "Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes",
abstract = "The capacity of B cells from patients with chronic lymphocytic leukaemia (CLL) to produce and secrete immunoglobulin following mitogen stimulation was investigated using sensitive radioimmunoassays for mu, gamma, alpha, kappa, and lambda immunoglobulin chains. Lymphocytes from seven of the 11 patients studied secreted immunoglobulin in response to pokeweed mitogen (PWM). IgM was always the major immunoglobulin and in five of the seven responders it was the only class detected; only one type of light chain was observed in most cases. This was in contrast to normal lymphocytes which secreted all classes of immunoglobulin (IgM was invariably the lowest) containing both types of light chain. Lipopolysaccharide induced immunoglobulin secretion in only one of four CLL cases. This was again IgM with only one type of light chain. The assays are therefore most probably measuring a response by the leukaemic cells. In most CLL cases, immunoglobulin secretion by the residual normal cells, which proliferate in response to mitogen, was not observed. This inability of the normal lymphocytes to differentiate fully into immunoglobulin secreting cells and the block in switching from IgM production to other classes in the leukaemic cells may both be attributable to a defect in the regulatory system of the immune response in CLL patients.",
keywords = "Aged, B-Lymphocytes, Female, Humans, Immunoglobulin Light Chains, Immunoglobulin M, Immunoglobulins, Leukemia, Lymphoid, Lipopolysaccharides, Male, Middle Aged, Mitogens, Pokeweed Mitogens",
author = "Johnstone, {A P} and Jensenius, {Jens Christian} and Millard, {R E} and L Hudson",
year = "1982",
language = "English",
volume = "47",
pages = "697--705",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes

AU - Johnstone, A P

AU - Jensenius, Jens Christian

AU - Millard, R E

AU - Hudson, L

PY - 1982

Y1 - 1982

N2 - The capacity of B cells from patients with chronic lymphocytic leukaemia (CLL) to produce and secrete immunoglobulin following mitogen stimulation was investigated using sensitive radioimmunoassays for mu, gamma, alpha, kappa, and lambda immunoglobulin chains. Lymphocytes from seven of the 11 patients studied secreted immunoglobulin in response to pokeweed mitogen (PWM). IgM was always the major immunoglobulin and in five of the seven responders it was the only class detected; only one type of light chain was observed in most cases. This was in contrast to normal lymphocytes which secreted all classes of immunoglobulin (IgM was invariably the lowest) containing both types of light chain. Lipopolysaccharide induced immunoglobulin secretion in only one of four CLL cases. This was again IgM with only one type of light chain. The assays are therefore most probably measuring a response by the leukaemic cells. In most CLL cases, immunoglobulin secretion by the residual normal cells, which proliferate in response to mitogen, was not observed. This inability of the normal lymphocytes to differentiate fully into immunoglobulin secreting cells and the block in switching from IgM production to other classes in the leukaemic cells may both be attributable to a defect in the regulatory system of the immune response in CLL patients.

AB - The capacity of B cells from patients with chronic lymphocytic leukaemia (CLL) to produce and secrete immunoglobulin following mitogen stimulation was investigated using sensitive radioimmunoassays for mu, gamma, alpha, kappa, and lambda immunoglobulin chains. Lymphocytes from seven of the 11 patients studied secreted immunoglobulin in response to pokeweed mitogen (PWM). IgM was always the major immunoglobulin and in five of the seven responders it was the only class detected; only one type of light chain was observed in most cases. This was in contrast to normal lymphocytes which secreted all classes of immunoglobulin (IgM was invariably the lowest) containing both types of light chain. Lipopolysaccharide induced immunoglobulin secretion in only one of four CLL cases. This was again IgM with only one type of light chain. The assays are therefore most probably measuring a response by the leukaemic cells. In most CLL cases, immunoglobulin secretion by the residual normal cells, which proliferate in response to mitogen, was not observed. This inability of the normal lymphocytes to differentiate fully into immunoglobulin secreting cells and the block in switching from IgM production to other classes in the leukaemic cells may both be attributable to a defect in the regulatory system of the immune response in CLL patients.

KW - Aged

KW - B-Lymphocytes

KW - Female

KW - Humans

KW - Immunoglobulin Light Chains

KW - Immunoglobulin M

KW - Immunoglobulins

KW - Leukemia, Lymphoid

KW - Lipopolysaccharides

KW - Male

KW - Middle Aged

KW - Mitogens

KW - Pokeweed Mitogens

M3 - Journal article

C2 - 6805990

VL - 47

SP - 697

EP - 705

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 3

ER -