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Jens Christian Jensenius

Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus

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Gram-positive organisms like Staphylococcus aureus are a major cause of morbidity and mortality worldwide. Humoral response molecules together with phagocytes play a role in host responses to S. aureus. The mannose-binding lectin (MBL, also known as mannose-binding protein) is an oligomeric serum molecule that recognizes carbohydrates decorating a broad range of infectious agents including S. aureus. Circumstantial evidence in vitro and in vivo suggests that MBL plays a key role in first line host defense. We tested this contention directly in vivo by generating mice that were devoid of all MBL activity. We found that 100% of MBL-null mice died 48 h after exposure to an intravenous inoculation of S. aureus compared with 45% mortality in wild-type mice. Furthermore, we demonstrated that neutrophils and MBL are required to limit intraperitoneal infection with S. aureus. Our study provides direct evidence that MBL plays a key role in restricting the complications associated with S. aureus infection in mice and raises the idea that the MBL gene may act as a disease susceptibility gene against staphylococci infections in humans.
Original languageEnglish
JournalJournal of Experimental Medicine
Volume199
Issue10
Pages (from-to)1379-90
Number of pages12
ISSN0022-1007
DOIs
Publication statusPublished - 2004

    Research areas

  • Animals, DNA, Bacterial, Disease Susceptibility, Lung, Mannose-Binding Lectin, Mice, Mice, Knockout, Reference Values, Reverse Transcriptase Polymerase Chain Reaction, Spleen, Staphylococcal Infections

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