Jens Christian Jensenius

Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer

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Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer. / Ytting, H; Christensen, I J; Steffensen, Rudi Nora; Alsner, Jan; Thiel, Steffen; Jensenius, Jens Christian; Hansen, U; Nielsen, H J.

In: Scandinavian Journal of Immunology, Vol. 73, No. 2, 01.02.2011, p. 122-7.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Ytting, H, Christensen, IJ, Steffensen, RN, Alsner, J, Thiel, S, Jensenius, JC, Hansen, U & Nielsen, HJ 2011, 'Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer', Scandinavian Journal of Immunology, vol. 73, no. 2, pp. 122-7. https://doi.org/10.1111/j.1365-3083.2010.02480.x

APA

Ytting, H., Christensen, I. J., Steffensen, R. N., Alsner, J., Thiel, S., Jensenius, J. C., Hansen, U., & Nielsen, H. J. (2011). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer. Scandinavian Journal of Immunology, 73(2), 122-7. https://doi.org/10.1111/j.1365-3083.2010.02480.x

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MLA

Vancouver

Author

Ytting, H ; Christensen, I J ; Steffensen, Rudi Nora ; Alsner, Jan ; Thiel, Steffen ; Jensenius, Jens Christian ; Hansen, U ; Nielsen, H J. / Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer. In: Scandinavian Journal of Immunology. 2011 ; Vol. 73, No. 2. pp. 122-7.

Bibtex

@article{3152e2d4739e4f00930fb913d4bfa17a,
title = "Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer",
abstract = "Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) are key factors of the lectin pathway of complement activation. Polymorphisms of the MBL2 and MASP-2 genes affect serum levels of MBL and MASP-2. In patients with colorectal cancer (CRC), the MBL and MASP-2 serum levels are increased and high MASP-2 levels are associated with recurrence and poor survival, whereas low MBL levels predict post-operative pneumonia. It is not known whether these associations are genetically based. In this study, the MBL and MASP-2 genotypes are investigated in 593 patients with CRC and 348 healthy controls. The potential association between genetic profile and infections, recurrence and survival is evaluated. Four single-nucleotide polymorphisms (SNPs) of MBL2 were analysed using TaqMan assays, with characterization of MBL2 wildtype A, variants B, C and D and alleles H/L, Y/X and P/Q. The SNP D120G for MASP-2 was determined. Serum levels of MBL and MASP-2 were measured. The MBL2 and MASP-2 genotype distribution was similar among patients with CRC and healthy controls and MBL2 genotype significantly associated with MBL concentration in serum (P",
keywords = "Adult, Aged, Aged, 80 and over, Colorectal Neoplasms, Female, Genotype, Humans, Male, Mannose-Binding Lectin, Mannose-Binding Protein-Associated Serine Proteases, Middle Aged, Treatment Outcome",
author = "H Ytting and Christensen, {I J} and Steffensen, {Rudi Nora} and Jan Alsner and Steffen Thiel and Jensenius, {Jens Christian} and U Hansen and Nielsen, {H J}",
note = "{\textcopyright} 2011 The Authors. Scandinavian Journal of Immunology {\textcopyright} 2011 Blackwell Publishing Ltd.",
year = "2011",
month = feb,
day = "1",
doi = "10.1111/j.1365-3083.2010.02480.x",
language = "English",
volume = "73",
pages = "122--7",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer

AU - Ytting, H

AU - Christensen, I J

AU - Steffensen, Rudi Nora

AU - Alsner, Jan

AU - Thiel, Steffen

AU - Jensenius, Jens Christian

AU - Hansen, U

AU - Nielsen, H J

N1 - © 2011 The Authors. Scandinavian Journal of Immunology © 2011 Blackwell Publishing Ltd.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) are key factors of the lectin pathway of complement activation. Polymorphisms of the MBL2 and MASP-2 genes affect serum levels of MBL and MASP-2. In patients with colorectal cancer (CRC), the MBL and MASP-2 serum levels are increased and high MASP-2 levels are associated with recurrence and poor survival, whereas low MBL levels predict post-operative pneumonia. It is not known whether these associations are genetically based. In this study, the MBL and MASP-2 genotypes are investigated in 593 patients with CRC and 348 healthy controls. The potential association between genetic profile and infections, recurrence and survival is evaluated. Four single-nucleotide polymorphisms (SNPs) of MBL2 were analysed using TaqMan assays, with characterization of MBL2 wildtype A, variants B, C and D and alleles H/L, Y/X and P/Q. The SNP D120G for MASP-2 was determined. Serum levels of MBL and MASP-2 were measured. The MBL2 and MASP-2 genotype distribution was similar among patients with CRC and healthy controls and MBL2 genotype significantly associated with MBL concentration in serum (P

AB - Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) are key factors of the lectin pathway of complement activation. Polymorphisms of the MBL2 and MASP-2 genes affect serum levels of MBL and MASP-2. In patients with colorectal cancer (CRC), the MBL and MASP-2 serum levels are increased and high MASP-2 levels are associated with recurrence and poor survival, whereas low MBL levels predict post-operative pneumonia. It is not known whether these associations are genetically based. In this study, the MBL and MASP-2 genotypes are investigated in 593 patients with CRC and 348 healthy controls. The potential association between genetic profile and infections, recurrence and survival is evaluated. Four single-nucleotide polymorphisms (SNPs) of MBL2 were analysed using TaqMan assays, with characterization of MBL2 wildtype A, variants B, C and D and alleles H/L, Y/X and P/Q. The SNP D120G for MASP-2 was determined. Serum levels of MBL and MASP-2 were measured. The MBL2 and MASP-2 genotype distribution was similar among patients with CRC and healthy controls and MBL2 genotype significantly associated with MBL concentration in serum (P

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Colorectal Neoplasms

KW - Female

KW - Genotype

KW - Humans

KW - Male

KW - Mannose-Binding Lectin

KW - Mannose-Binding Protein-Associated Serine Proteases

KW - Middle Aged

KW - Treatment Outcome

U2 - 10.1111/j.1365-3083.2010.02480.x

DO - 10.1111/j.1365-3083.2010.02480.x

M3 - Journal article

C2 - 21198752

VL - 73

SP - 122

EP - 127

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

IS - 2

ER -