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Jens Christian Jensenius

Mannan-binding lectin deficiency is associated with unexplained recurrent miscarriage

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  • Department of Medical Microbiology and Immunology
Mannan-binding lectin (MBL) is a plasma protein which, upon binding to microbial carbohydrate structures, elicits activation of the complement system. The level of MBL is genetically determined. It has been reported that the frequency of low plasma levels of MBL is increased in patients with unexplained recurrent miscarriages (RM). In the present study plasma MBL levels were determined in 146 Danish women with RM and 41 of their husbands together with 49 Scottish RM women and 41 of their husbands. In both countries MBL levels were also investigated in a total of 444 controls. Based on the control data, a cut-off MBL level <50 ng/ml was selected to define MBL deficiency. The typical odds ratio for MBL deficiency among female patients in the two populations was 1.68 (95% confidence limits 1.01-2.80, P
Original languageEnglish
JournalScandinavian Journal of Immunology
Volume49
Issue2
Pages (from-to)193-6
Number of pages4
ISSN0300-9475
Publication statusPublished - 1 Feb 1999

    Research areas

  • Abortion, Habitual, Carrier Proteins, Cohort Studies, Collectins, Cross-Sectional Studies, Denmark, Female, Humans, Lectins, Male, Mannans, Odds Ratio, Pregnancy, Prospective Studies, Scotland

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