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Jens Christian Jensenius

Levels of lectin pathway proteins in plasma and synovial fluid of rheumatoid arthritis and osteoarthritis

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Levels of lectin pathway proteins in plasma and synovial fluid of rheumatoid arthritis and osteoarthritis. / Ammitzboll, C G; Thiel, S; Ellingsen, T; Deleuran, B; Jorgensen, Anette; Jensenius, Jens Christian; Stengaard-Pedersen, K.

In: Rheumatology International, 2011.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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@article{aeb3a6971711481ca1d302dd4a1b34a0,
title = "Levels of lectin pathway proteins in plasma and synovial fluid of rheumatoid arthritis and osteoarthritis",
abstract = "The innate immune system contributes to the development of rheumatoid arthritis (RA). A potent contributor to such processes is the complement system. The complement system is known to be activated in the inflammatory phases of osteoarthritis (OA). The lectin pathway of the complement system is activated through the recognition of pathogens or altered self-structures by mannan-binding lectin (MBL) or one of the three ficolins in collaboration with MBL-associated serine proteases (MASPs). We assessed the lectin pathway in plasma and synovial fluid (SF) of 27 RA patients and 30 OA patients by measuring MBL, MASP-2, MASP-3, M-ficolin, and H-ficolin. The concentration for all 5 proteins was significantly higher in plasma than in SF (P ",
author = "Ammitzboll, {C G} and S Thiel and T Ellingsen and B Deleuran and Anette Jorgensen and Jensenius, {Jens Christian} and K Stengaard-Pedersen",
year = "2011",
doi = "10.1007/s00296-011-1879-x",
language = "English",
journal = "Rheumatology International",
issn = "0172-8172",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Levels of lectin pathway proteins in plasma and synovial fluid of rheumatoid arthritis and osteoarthritis

AU - Ammitzboll, C G

AU - Thiel, S

AU - Ellingsen, T

AU - Deleuran, B

AU - Jorgensen, Anette

AU - Jensenius, Jens Christian

AU - Stengaard-Pedersen, K

PY - 2011

Y1 - 2011

N2 - The innate immune system contributes to the development of rheumatoid arthritis (RA). A potent contributor to such processes is the complement system. The complement system is known to be activated in the inflammatory phases of osteoarthritis (OA). The lectin pathway of the complement system is activated through the recognition of pathogens or altered self-structures by mannan-binding lectin (MBL) or one of the three ficolins in collaboration with MBL-associated serine proteases (MASPs). We assessed the lectin pathway in plasma and synovial fluid (SF) of 27 RA patients and 30 OA patients by measuring MBL, MASP-2, MASP-3, M-ficolin, and H-ficolin. The concentration for all 5 proteins was significantly higher in plasma than in SF (P 

AB - The innate immune system contributes to the development of rheumatoid arthritis (RA). A potent contributor to such processes is the complement system. The complement system is known to be activated in the inflammatory phases of osteoarthritis (OA). The lectin pathway of the complement system is activated through the recognition of pathogens or altered self-structures by mannan-binding lectin (MBL) or one of the three ficolins in collaboration with MBL-associated serine proteases (MASPs). We assessed the lectin pathway in plasma and synovial fluid (SF) of 27 RA patients and 30 OA patients by measuring MBL, MASP-2, MASP-3, M-ficolin, and H-ficolin. The concentration for all 5 proteins was significantly higher in plasma than in SF (P 

U2 - 10.1007/s00296-011-1879-x

DO - 10.1007/s00296-011-1879-x

M3 - Journal article

JO - Rheumatology International

JF - Rheumatology International

SN - 0172-8172

ER -