Jens Christian Jensenius

Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus

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Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus. / Troldborg, Anne; Thiel, Steffen; Laska, Magdalena Janina; Deleuran, Bent; Jensenius, Jens Christian; Stengaard-Pedersen, Kristian.

In: Journal of Rheumatology, Vol. 42, No. 6, 06.2015, p. 948-51.

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@article{36f7ac22c99a40dca753d1439b2669ba,
title = "Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus",
abstract = "OBJECTIVE: To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis.METHODS: Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC).RESULTS: Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133).CONCLUSION: In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis.",
author = "Anne Troldborg and Steffen Thiel and Laska, {Magdalena Janina} and Bent Deleuran and Jensenius, {Jens Christian} and Kristian Stengaard-Pedersen",
year = "2015",
month = "6",
doi = "10.3899/jrheum.141163",
language = "English",
volume = "42",
pages = "948--51",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology Publishing Co. Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus

AU - Troldborg, Anne

AU - Thiel, Steffen

AU - Laska, Magdalena Janina

AU - Deleuran, Bent

AU - Jensenius, Jens Christian

AU - Stengaard-Pedersen, Kristian

PY - 2015/6

Y1 - 2015/6

N2 - OBJECTIVE: To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis.METHODS: Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC).RESULTS: Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133).CONCLUSION: In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis.

AB - OBJECTIVE: To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis.METHODS: Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC).RESULTS: Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133).CONCLUSION: In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis.

U2 - 10.3899/jrheum.141163

DO - 10.3899/jrheum.141163

M3 - Journal article

VL - 42

SP - 948

EP - 951

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 6

ER -