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Jens Christian Jensenius

Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus

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Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus. / Troldborg, Anne; Thiel, Steffen; Laska, Magdalena Janina; Deleuran, Bent; Jensenius, Jens Christian; Stengaard-Pedersen, Kristian.

In: Journal of Rheumatology, Vol. 42, No. 6, 06.2015, p. 948-51.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Troldborg, A, Thiel, S, Laska, MJ, Deleuran, B, Jensenius, JC & Stengaard-Pedersen, K 2015, 'Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus', Journal of Rheumatology, vol. 42, no. 6, pp. 948-51. https://doi.org/10.3899/jrheum.141163

APA

Troldborg, A., Thiel, S., Laska, M. J., Deleuran, B., Jensenius, J. C., & Stengaard-Pedersen, K. (2015). Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus. Journal of Rheumatology, 42(6), 948-51. https://doi.org/10.3899/jrheum.141163

CBE

Troldborg A, Thiel S, Laska MJ, Deleuran B, Jensenius JC, Stengaard-Pedersen K. 2015. Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus. Journal of Rheumatology. 42(6):948-51. https://doi.org/10.3899/jrheum.141163

MLA

Troldborg, Anne et al. "Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus". Journal of Rheumatology. 2015, 42(6). 948-51. https://doi.org/10.3899/jrheum.141163

Vancouver

Troldborg A, Thiel S, Laska MJ, Deleuran B, Jensenius JC, Stengaard-Pedersen K. Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus. Journal of Rheumatology. 2015 Jun;42(6):948-51. https://doi.org/10.3899/jrheum.141163

Author

Troldborg, Anne ; Thiel, Steffen ; Laska, Magdalena Janina ; Deleuran, Bent ; Jensenius, Jens Christian ; Stengaard-Pedersen, Kristian. / Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus. In: Journal of Rheumatology. 2015 ; Vol. 42, No. 6. pp. 948-51.

Bibtex

@article{36f7ac22c99a40dca753d1439b2669ba,
title = "Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus",
abstract = "OBJECTIVE: To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis.METHODS: Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC).RESULTS: Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133).CONCLUSION: In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis.",
author = "Anne Troldborg and Steffen Thiel and Laska, {Magdalena Janina} and Bent Deleuran and Jensenius, {Jens Christian} and Kristian Stengaard-Pedersen",
year = "2015",
month = "6",
doi = "10.3899/jrheum.141163",
language = "English",
volume = "42",
pages = "948--51",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology Publishing Co. Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus

AU - Troldborg, Anne

AU - Thiel, Steffen

AU - Laska, Magdalena Janina

AU - Deleuran, Bent

AU - Jensenius, Jens Christian

AU - Stengaard-Pedersen, Kristian

PY - 2015/6

Y1 - 2015/6

N2 - OBJECTIVE: To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis.METHODS: Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC).RESULTS: Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133).CONCLUSION: In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis.

AB - OBJECTIVE: To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis.METHODS: Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC).RESULTS: Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133).CONCLUSION: In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis.

U2 - 10.3899/jrheum.141163

DO - 10.3899/jrheum.141163

M3 - Journal article

VL - 42

SP - 948

EP - 951

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 6

ER -