Jens Christian Jensenius

Leprosy association with low MASP-2 levels generated by MASP2 haplotypes and polymorphisms flanking MAp19 exon 5

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Angelica Beate Winter Boldt, Laboratório de Imunopatologia Molecular - Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, BR. iarareason@hc.ufpr.br
  • ,
  • Isabela Goeldner
  • ,
  • Ewalda R S Stahlke
  • ,
  • Steffen Thiel
  • Jens Christian Jensenius
  • Iara José Taborda de Messias-Reason
The gene MASP2 (mannan-binding lectin (MBL)-associated serine protease 2) encodes two proteins, MASP-2 and MAp19 (MBL-associated protein of 19 kDa), bound in plasma to MBL and ficolins. The binding of MBL/MASP-2 and ficolin/MASP-2 complexes to microorganisms activates the lectin pathway of complement and may increase the ingestion of intracellular pathogens such as Mycobacterium leprae.
Original languageEnglish
JournalPLOS ONE
Volume8
Issue7
Pages (from-to)e69054
ISSN1932-6203
DOIs
Publication statusPublished - 2013

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