Aarhus University Seal / Aarhus Universitets segl

Jens Christian Jensenius

Influence of mesonephros on foetal and neonatal rabbit gonads. I. Sex-steroid release by the testis in vitro

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

The experiments were performed to study the influence of mesonephros on gonadal sex hormone release. Foetal and neonatal rabbit testes were cultured for 5 days, with and without their mesonephric tissue. The culture media were harvested every day and analyzed by RIA for the content of testosterone, progesterone and oestradiol. The development of the tissues were evaluated microscopically after culturing. The results show that between day 20 pc and day 1 pp the mesonephric tissue lowered the amounts of testosterone in co-cultures with testis. This effect disappears when the mesonephric derived cells develop the capacity to synthesize a meiosis inducing substance (MIS). A relationship between decrease of testosterone and secretion of MIS is discussed. It is concluded that the steroid producing cells of the testis, the Leydig cells, originate or are heavily influenced by mesonephros during early testicular organogenesis.
Original languageEnglish
JournalActa Endocrinologica
Pages (from-to)272-80
Number of pages9
Publication statusPublished - 1982

    Research areas

  • Animals, Animals, Newborn, Cells, Cultured, Estradiol, Gonadal Steroid Hormones, Male, Mesonephros, Progesterone, Rabbits, Radioimmunoassay, Testis, Testosterone

See relations at Aarhus University Citationformats

ID: 43924506