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Jens Christian Jensenius

Influence of major surgery on the mannan-binding lectin pathway of innate immunity

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Influence of major surgery on the mannan-binding lectin pathway of innate immunity. / Ytting, H.; Christensen, I.J.; Basse, L.; Lykke, J.; Thiel, Steffen; Jensenius, Jens Christian; Nielsen, H.J.

In: Clin. Exp. Immunol., Vol. 144, 2006, p. 239-46.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Ytting, H, Christensen, IJ, Basse, L, Lykke, J, Thiel, S, Jensenius, JC & Nielsen, HJ 2006, 'Influence of major surgery on the mannan-binding lectin pathway of innate immunity', Clin. Exp. Immunol., vol. 144, pp. 239-46.

APA

Ytting, H., Christensen, I. J., Basse, L., Lykke, J., Thiel, S., Jensenius, J. C., & Nielsen, H. J. (2006). Influence of major surgery on the mannan-binding lectin pathway of innate immunity. Clin. Exp. Immunol., 144, 239-46.

CBE

Ytting H, Christensen IJ, Basse L, Lykke J, Thiel S, Jensenius JC, Nielsen HJ. 2006. Influence of major surgery on the mannan-binding lectin pathway of innate immunity. Clin. Exp. Immunol. 144:239-46.

MLA

Ytting, H. et al. "Influence of major surgery on the mannan-binding lectin pathway of innate immunity". Clin. Exp. Immunol. 2006, 144. 239-46.

Vancouver

Ytting H, Christensen IJ, Basse L, Lykke J, Thiel S, Jensenius JC et al. Influence of major surgery on the mannan-binding lectin pathway of innate immunity. Clin. Exp. Immunol. 2006;144:239-46.

Author

Ytting, H. ; Christensen, I.J. ; Basse, L. ; Lykke, J. ; Thiel, Steffen ; Jensenius, Jens Christian ; Nielsen, H.J. / Influence of major surgery on the mannan-binding lectin pathway of innate immunity. In: Clin. Exp. Immunol. 2006 ; Vol. 144. pp. 239-46.

Bibtex

@article{94d6f37059d611dbbee902004c4f4f50,
title = "Influence of major surgery on the mannan-binding lectin pathway of innate immunity",
abstract = "The mannan-binding lectin (MBL) pathway of complement activation is important in host defence against pathogens and possibly against cancer. We investigated the effect of major surgery on two central components of the MBL pathway; MBL and the MBL-associated serine protease MASP-2, and for comparison also measured the interleukin (IL)-6 and C-reactive protein (CRP) levels. Serial blood samples were obtained from patients belonging to two different cohorts. Cohort 1 comprised 60 patients undergoing open or laparoscopic colectomy for benign disease (n = 12) or colon cancer (n = 48). Cohort 2 comprised 27 patients undergoing elective, open surgery for colorectal cancer, and was included in order to cover blood sampling between days 2 and 6. As expected, the surgical stress induced a marked acute phase response, as evidenced by a large increase in IL-6 (18-fold) and CRP (13-fold) levels with maximum at 12 h and 2 days, respectively. However, in both cohorts the levels of MBL and MBL-associated serine protease 2 (MASP-2) were largely unaffected, except for a minor but significant increase around day 8 in cohort 1. The preoperative levels of IL-6 and CRP were correlated significantly in both cohorts (r = 0.71, P < 0.0001 and r = 0.65, P = 0.005, respectively). Preoperative MASP-2 correlated with preoperative CRP (r = 0.59, P = 0.001) and IL-6 (r = 0.55, P = 0.02) in cohort 2 only. In contrast to the marked effects on the levels of IL-6 and CRP, the surgery influenced only marginally the two proteins of the MBL pathway.",
author = "H. Ytting and I.J. Christensen and L. Basse and J. Lykke and Steffen Thiel and Jensenius, {Jens Christian} and H.J. Nielsen",
year = "2006",
language = "English",
volume = "144",
pages = "239--46",
journal = "Clin. Exp. Immunol.",

}

RIS

TY - JOUR

T1 - Influence of major surgery on the mannan-binding lectin pathway of innate immunity

AU - Ytting, H.

AU - Christensen, I.J.

AU - Basse, L.

AU - Lykke, J.

AU - Thiel, Steffen

AU - Jensenius, Jens Christian

AU - Nielsen, H.J.

PY - 2006

Y1 - 2006

N2 - The mannan-binding lectin (MBL) pathway of complement activation is important in host defence against pathogens and possibly against cancer. We investigated the effect of major surgery on two central components of the MBL pathway; MBL and the MBL-associated serine protease MASP-2, and for comparison also measured the interleukin (IL)-6 and C-reactive protein (CRP) levels. Serial blood samples were obtained from patients belonging to two different cohorts. Cohort 1 comprised 60 patients undergoing open or laparoscopic colectomy for benign disease (n = 12) or colon cancer (n = 48). Cohort 2 comprised 27 patients undergoing elective, open surgery for colorectal cancer, and was included in order to cover blood sampling between days 2 and 6. As expected, the surgical stress induced a marked acute phase response, as evidenced by a large increase in IL-6 (18-fold) and CRP (13-fold) levels with maximum at 12 h and 2 days, respectively. However, in both cohorts the levels of MBL and MBL-associated serine protease 2 (MASP-2) were largely unaffected, except for a minor but significant increase around day 8 in cohort 1. The preoperative levels of IL-6 and CRP were correlated significantly in both cohorts (r = 0.71, P < 0.0001 and r = 0.65, P = 0.005, respectively). Preoperative MASP-2 correlated with preoperative CRP (r = 0.59, P = 0.001) and IL-6 (r = 0.55, P = 0.02) in cohort 2 only. In contrast to the marked effects on the levels of IL-6 and CRP, the surgery influenced only marginally the two proteins of the MBL pathway.

AB - The mannan-binding lectin (MBL) pathway of complement activation is important in host defence against pathogens and possibly against cancer. We investigated the effect of major surgery on two central components of the MBL pathway; MBL and the MBL-associated serine protease MASP-2, and for comparison also measured the interleukin (IL)-6 and C-reactive protein (CRP) levels. Serial blood samples were obtained from patients belonging to two different cohorts. Cohort 1 comprised 60 patients undergoing open or laparoscopic colectomy for benign disease (n = 12) or colon cancer (n = 48). Cohort 2 comprised 27 patients undergoing elective, open surgery for colorectal cancer, and was included in order to cover blood sampling between days 2 and 6. As expected, the surgical stress induced a marked acute phase response, as evidenced by a large increase in IL-6 (18-fold) and CRP (13-fold) levels with maximum at 12 h and 2 days, respectively. However, in both cohorts the levels of MBL and MBL-associated serine protease 2 (MASP-2) were largely unaffected, except for a minor but significant increase around day 8 in cohort 1. The preoperative levels of IL-6 and CRP were correlated significantly in both cohorts (r = 0.71, P < 0.0001 and r = 0.65, P = 0.005, respectively). Preoperative MASP-2 correlated with preoperative CRP (r = 0.59, P = 0.001) and IL-6 (r = 0.55, P = 0.02) in cohort 2 only. In contrast to the marked effects on the levels of IL-6 and CRP, the surgery influenced only marginally the two proteins of the MBL pathway.

M3 - Journal article

VL - 144

SP - 239

EP - 246

JO - Clin. Exp. Immunol.

JF - Clin. Exp. Immunol.

ER -