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Jens Christian Jensenius

Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens

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Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens. / Husby, Sofie; Oxelius, V A; Teisner, Børge; Jensenius, Jens Christian; Svehag, S E.

In: International Archives of Allergy and Applied Immunology, Vol. 77, No. 4, 1985, p. 416-22.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Husby, S, Oxelius, VA, Teisner, B, Jensenius, JC & Svehag, SE 1985, 'Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens', International Archives of Allergy and Applied Immunology, vol. 77, no. 4, pp. 416-22.

APA

Husby, S., Oxelius, V. A., Teisner, B., Jensenius, J. C., & Svehag, S. E. (1985). Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens. International Archives of Allergy and Applied Immunology, 77(4), 416-22.

CBE

Husby S, Oxelius VA, Teisner B, Jensenius JC, Svehag SE. 1985. Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens. International Archives of Allergy and Applied Immunology. 77(4):416-22.

MLA

Husby, Sofie et al. "Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens". International Archives of Allergy and Applied Immunology. 1985, 77(4). 416-22.

Vancouver

Husby S, Oxelius VA, Teisner B, Jensenius JC, Svehag SE. Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens. International Archives of Allergy and Applied Immunology. 1985;77(4):416-22.

Author

Husby, Sofie ; Oxelius, V A ; Teisner, Børge ; Jensenius, Jens Christian ; Svehag, S E. / Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens. In: International Archives of Allergy and Applied Immunology. 1985 ; Vol. 77, No. 4. pp. 416-22.

Bibtex

@article{b4a9ffccf7884ea19336bcfca72231b1,
title = "Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens",
abstract = "The occurrence of antibodies to five dietary protein antigens in the sera from 21 healthy adults was investigated by a modified Farr assay. Antibody to ovalbumin (OA) occurred most frequently (90%) whereas only 24% had antibodies to alpha-lactalbumin (ALA). No correlation was noted between the titer of antibodies against bovine serum albumin (BSA) and OA in the single individual. The avidity constants (10(8)-10(9) l/mol) and cross-reactivities against other albumins of anti-BSA antibodies in two human sera were comparable to that of the antibodies in pooled hyperimmune rabbit antiserum. Crossed radioimmunoelectrophoresis showed serum anti-BSA and anti-OA antibodies to be predominantly of the IgG class (13/13, 10/10), occasionally of the IgA- (6/13, 1/10) and rarely of the IgM class (1/13, 0/10). Analysis by radioelectroimmunoassay (rocket immunoelectrophoresis) of the IgG subclass distribution of anti-BSA and anti-OA antibodies showed total absence of IgG3. In contrast, antibodies of the IgG4 subclass were frequently present even in sera with very low levels of total IgG4.",
keywords = "Adult, Antibody Affinity, Antigens, Cross Reactions, Dietary Proteins, Female, Food Hypersensitivity, Humans, Immunoglobulin Allotypes, Immunoglobulin G, Male, Middle Aged, Ovalbumin, Serum Albumin, Bovine",
author = "Sofie Husby and Oxelius, {V A} and B{\o}rge Teisner and Jensenius, {Jens Christian} and Svehag, {S E}",
year = "1985",
language = "English",
volume = "77",
pages = "416--22",
journal = "International Archives of Allergy and Applied Immunology",
issn = "0020-5915",
publisher = "S. Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens

AU - Husby, Sofie

AU - Oxelius, V A

AU - Teisner, Børge

AU - Jensenius, Jens Christian

AU - Svehag, S E

PY - 1985

Y1 - 1985

N2 - The occurrence of antibodies to five dietary protein antigens in the sera from 21 healthy adults was investigated by a modified Farr assay. Antibody to ovalbumin (OA) occurred most frequently (90%) whereas only 24% had antibodies to alpha-lactalbumin (ALA). No correlation was noted between the titer of antibodies against bovine serum albumin (BSA) and OA in the single individual. The avidity constants (10(8)-10(9) l/mol) and cross-reactivities against other albumins of anti-BSA antibodies in two human sera were comparable to that of the antibodies in pooled hyperimmune rabbit antiserum. Crossed radioimmunoelectrophoresis showed serum anti-BSA and anti-OA antibodies to be predominantly of the IgG class (13/13, 10/10), occasionally of the IgA- (6/13, 1/10) and rarely of the IgM class (1/13, 0/10). Analysis by radioelectroimmunoassay (rocket immunoelectrophoresis) of the IgG subclass distribution of anti-BSA and anti-OA antibodies showed total absence of IgG3. In contrast, antibodies of the IgG4 subclass were frequently present even in sera with very low levels of total IgG4.

AB - The occurrence of antibodies to five dietary protein antigens in the sera from 21 healthy adults was investigated by a modified Farr assay. Antibody to ovalbumin (OA) occurred most frequently (90%) whereas only 24% had antibodies to alpha-lactalbumin (ALA). No correlation was noted between the titer of antibodies against bovine serum albumin (BSA) and OA in the single individual. The avidity constants (10(8)-10(9) l/mol) and cross-reactivities against other albumins of anti-BSA antibodies in two human sera were comparable to that of the antibodies in pooled hyperimmune rabbit antiserum. Crossed radioimmunoelectrophoresis showed serum anti-BSA and anti-OA antibodies to be predominantly of the IgG class (13/13, 10/10), occasionally of the IgA- (6/13, 1/10) and rarely of the IgM class (1/13, 0/10). Analysis by radioelectroimmunoassay (rocket immunoelectrophoresis) of the IgG subclass distribution of anti-BSA and anti-OA antibodies showed total absence of IgG3. In contrast, antibodies of the IgG4 subclass were frequently present even in sera with very low levels of total IgG4.

KW - Adult

KW - Antibody Affinity

KW - Antigens

KW - Cross Reactions

KW - Dietary Proteins

KW - Female

KW - Food Hypersensitivity

KW - Humans

KW - Immunoglobulin Allotypes

KW - Immunoglobulin G

KW - Male

KW - Middle Aged

KW - Ovalbumin

KW - Serum Albumin, Bovine

M3 - Journal article

C2 - 4018884

VL - 77

SP - 416

EP - 422

JO - International Archives of Allergy and Applied Immunology

JF - International Archives of Allergy and Applied Immunology

SN - 0020-5915

IS - 4

ER -