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Jens Christian Jensenius

Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity.

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Standard

Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity. / Sørensen, GL; Petersen, I; Thiel, Steffen; Fenger, M; Christensen, K; Kyvik, KO; Sørensen, TJ; Holmskov, U; Jensenius, Jens Christian.

In: Genetic Epidemiology, Vol. 31, 2007, p. 31-41.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Sørensen, GL, Petersen, I, Thiel, S, Fenger, M, Christensen, K, Kyvik, KO, Sørensen, TJ, Holmskov, U & Jensenius, JC 2007, 'Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity.', Genetic Epidemiology, vol. 31, pp. 31-41.

APA

Sørensen, GL., Petersen, I., Thiel, S., Fenger, M., Christensen, K., Kyvik, KO., ... Jensenius, J. C. (2007). Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity. Genetic Epidemiology, 31, 31-41.

CBE

Sørensen GL, Petersen I, Thiel S, Fenger M, Christensen K, Kyvik KO, Sørensen TJ, Holmskov U, Jensenius JC. 2007. Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity. Genetic Epidemiology. 31:31-41.

MLA

Vancouver

Sørensen GL, Petersen I, Thiel S, Fenger M, Christensen K, Kyvik KO et al. Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity. Genetic Epidemiology. 2007;31:31-41.

Author

Sørensen, GL ; Petersen, I ; Thiel, Steffen ; Fenger, M ; Christensen, K ; Kyvik, KO ; Sørensen, TJ ; Holmskov, U ; Jensenius, Jens Christian. / Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity. In: Genetic Epidemiology. 2007 ; Vol. 31. pp. 31-41.

Bibtex

@article{f40c0db09cd511dcbee902004c4f4f50,
title = "Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity.",
abstract = "The lectin pathway of the complement system is activated when Mannan-binding lectin (MBL) in complex with MASP-2 binds microorganisms. Polymorphisms in both genes are responsible for low serum levels, which associate with increased risk of infection and autoimmune disease. The present study includes 1215 MBL measurements and 1214 MASP-2 activity measurements in healthy Danish adult twins. Total MASP-2 activity was estimated by C4 cleaving activity of samples diluted in an excess of MBL. Twin-twin correlations were higher in monozygotic (MZ) than in dizygotic (DZ) twins for both traits. Heritabilites of MBL levels and MASP-2 activity were estimated using structural equation modeling allowing assessment of the contribution of common genes affecting both traits. The estimated heritability was 0.77 [95{\%} CI 0.64;0.91] for MBL levels and 0.75 [95{\%} CI 0.59;0.81] for MASP-2 activity with the presence of additive genetic factors, shared environmental factors, and non-shared environmental factors. The genetic correlation, i.e., common genetic factors affecting MBL and MASP-2 activity was estimated to r(g) = 0.34 [0.25;0.42]. The data indicate a strong genetic influence for the serum levels of MBL and for MASP-2 activity with a significant genetic correlation between the two traits.",
author = "GL S{\o}rensen and I Petersen and Steffen Thiel and M Fenger and K Christensen and KO Kyvik and TJ S{\o}rensen and U Holmskov and Jensenius, {Jens Christian}",
year = "2007",
language = "English",
volume = "31",
pages = "31--41",
journal = "Genetic Epidemiology",
issn = "0741-0395",
publisher = "JohnWiley & Sons, Inc.",

}

RIS

TY - JOUR

T1 - Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity.

AU - Sørensen, GL

AU - Petersen, I

AU - Thiel, Steffen

AU - Fenger, M

AU - Christensen, K

AU - Kyvik, KO

AU - Sørensen, TJ

AU - Holmskov, U

AU - Jensenius, Jens Christian

PY - 2007

Y1 - 2007

N2 - The lectin pathway of the complement system is activated when Mannan-binding lectin (MBL) in complex with MASP-2 binds microorganisms. Polymorphisms in both genes are responsible for low serum levels, which associate with increased risk of infection and autoimmune disease. The present study includes 1215 MBL measurements and 1214 MASP-2 activity measurements in healthy Danish adult twins. Total MASP-2 activity was estimated by C4 cleaving activity of samples diluted in an excess of MBL. Twin-twin correlations were higher in monozygotic (MZ) than in dizygotic (DZ) twins for both traits. Heritabilites of MBL levels and MASP-2 activity were estimated using structural equation modeling allowing assessment of the contribution of common genes affecting both traits. The estimated heritability was 0.77 [95% CI 0.64;0.91] for MBL levels and 0.75 [95% CI 0.59;0.81] for MASP-2 activity with the presence of additive genetic factors, shared environmental factors, and non-shared environmental factors. The genetic correlation, i.e., common genetic factors affecting MBL and MASP-2 activity was estimated to r(g) = 0.34 [0.25;0.42]. The data indicate a strong genetic influence for the serum levels of MBL and for MASP-2 activity with a significant genetic correlation between the two traits.

AB - The lectin pathway of the complement system is activated when Mannan-binding lectin (MBL) in complex with MASP-2 binds microorganisms. Polymorphisms in both genes are responsible for low serum levels, which associate with increased risk of infection and autoimmune disease. The present study includes 1215 MBL measurements and 1214 MASP-2 activity measurements in healthy Danish adult twins. Total MASP-2 activity was estimated by C4 cleaving activity of samples diluted in an excess of MBL. Twin-twin correlations were higher in monozygotic (MZ) than in dizygotic (DZ) twins for both traits. Heritabilites of MBL levels and MASP-2 activity were estimated using structural equation modeling allowing assessment of the contribution of common genes affecting both traits. The estimated heritability was 0.77 [95% CI 0.64;0.91] for MBL levels and 0.75 [95% CI 0.59;0.81] for MASP-2 activity with the presence of additive genetic factors, shared environmental factors, and non-shared environmental factors. The genetic correlation, i.e., common genetic factors affecting MBL and MASP-2 activity was estimated to r(g) = 0.34 [0.25;0.42]. The data indicate a strong genetic influence for the serum levels of MBL and for MASP-2 activity with a significant genetic correlation between the two traits.

M3 - Journal article

VL - 31

SP - 31

EP - 41

JO - Genetic Epidemiology

JF - Genetic Epidemiology

SN - 0741-0395

ER -