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Jens Christian Jensenius

Evidence for two populations of B-L (Ia-like) molecules encoded by the chicken MHC

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Two specific alloantisera detecting B-L (Ia-like) antigens on chicken lymphocytes of the B6 and B15 haplotypes were found to cross-react strongly. Anti-B-L6 and anti-B-L15 alloantisera both reacted with B-L molecules on B6 and B15 lymphocytes as demonstrated by immunofluorescence and SDS-PAGE analysis of 125I-labeled B-L antigens isolated by incubation with anti-B-L alloantisera. Absorption studies showed that the anti-B-L alloantisera reacted with at least two kinds of antigenic determinant, one set shared by B-L6 and B-L15 molecules and another set specific for each haplotype. In spite of the absence of genetic evidence for more than one B-L locus in the chicken B complex, it was shown by sequential antibody incubations that these two different B-L antigenic determinants are associated with at least two separate species of B-L molecules, indicating the presence of at least two B-L loci within the MHC of the chicken.
Original languageEnglish
Pages (from-to)381-91
Number of pages11
Publication statusPublished - 1981

    Research areas

  • Animals, B-Lymphocytes, Chickens, Chromosome Mapping, Electrophoresis, Polyacrylamide Gel, Genes, Histocompatibility Antigens Class II, Major Histocompatibility Complex, T-Lymphocytes

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