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Jens Christian Jensenius

Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus

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Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus. / Messias-Reason, I; Bosco, D G; Nisihara, R M; Jakobsen, L H; Petzl-Erler, M L; Jensenius, Jens Christian.

In: Clinical and Experimental Dermatology. Supplement, Vol. 33, No. 4, 2008, p. 495-7.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Messias-Reason, I, Bosco, DG, Nisihara, RM, Jakobsen, LH, Petzl-Erler, ML & Jensenius, JC 2008, 'Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus', Clinical and Experimental Dermatology. Supplement, vol. 33, no. 4, pp. 495-7. https://doi.org/10.1111/j.1365-2230.2008.02743.x

APA

Messias-Reason, I., Bosco, D. G., Nisihara, R. M., Jakobsen, L. H., Petzl-Erler, M. L., & Jensenius, J. C. (2008). Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus. Clinical and Experimental Dermatology. Supplement, 33(4), 495-7. https://doi.org/10.1111/j.1365-2230.2008.02743.x

CBE

Messias-Reason I, Bosco DG, Nisihara RM, Jakobsen LH, Petzl-Erler ML, Jensenius JC. 2008. Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus. Clinical and Experimental Dermatology. Supplement. 33(4):495-7. https://doi.org/10.1111/j.1365-2230.2008.02743.x

MLA

Vancouver

Messias-Reason I, Bosco DG, Nisihara RM, Jakobsen LH, Petzl-Erler ML, Jensenius JC. Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus. Clinical and Experimental Dermatology. Supplement. 2008;33(4):495-7. https://doi.org/10.1111/j.1365-2230.2008.02743.x

Author

Messias-Reason, I ; Bosco, D G ; Nisihara, R M ; Jakobsen, L H ; Petzl-Erler, M L ; Jensenius, Jens Christian. / Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus. In: Clinical and Experimental Dermatology. Supplement. 2008 ; Vol. 33, No. 4. pp. 495-7.

Bibtex

@article{6874e20fcf6d4c59bfd71abff6a694c2,
title = "Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus",
abstract = "Endemic pemphigus foliaceus (EPF) is an autoimmune disease, which occurs in Brazil and other regions of South America. Mannose-binding lectin (MBL) and MBL-associated serine protease (MASP-2) play a key role in innate immunity, and its deficiency has been related to increased susceptibility to infection and autoimmune diseases. MBL and MASP-2 serum levels were measured in 114 patients with EPF and in 100 healthy individuals in Brazil. MBL and MASP-2 levels were measured by sandwich assays (time-resolved immunofluorimetic assay) using monoclonal antibodies. No difference was observed in the MBL level in patients with EPF compared with controls [mean +/- SEM 1230.07 +/- 132.18 ng/mL (median 789.0 ng/mL) vs. 1036.98 +/- 117.99 ng/mL (median 559.5 ng/mL), P = 0.32]. Non-significant lower MASP-2 levels were observed in EPF [274.34 +/- 15.66 ng/mL (median 239.5 ng/mL ) vs. 304.72 +/- 15.28 ng/mL [median 261.0 ng/mL ), P = 0.06]. MBL deficiency (<10 ng/mL) or MASP-2 deficiency (<100 ng/mL) did not differ significantly between patients and controls. These data indicate that MBL and MASP-2 deficiency are not associated with susceptibility to EPF.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Child, Complement Pathway, Classical, Female, Genotype, Humans, Male, Mannose-Binding Lectin, Mannose-Binding Protein-Associated Serine Proteases, Middle Aged, Pemphigus",
author = "I Messias-Reason and Bosco, {D G} and Nisihara, {R M} and Jakobsen, {L H} and Petzl-Erler, {M L} and Jensenius, {Jens Christian}",
year = "2008",
doi = "10.1111/j.1365-2230.2008.02743.x",
language = "English",
volume = "33",
pages = "495--7",
journal = "Clinical and Experimental Dermatology. Supplement",
issn = "0966-3487",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus

AU - Messias-Reason, I

AU - Bosco, D G

AU - Nisihara, R M

AU - Jakobsen, L H

AU - Petzl-Erler, M L

AU - Jensenius, Jens Christian

PY - 2008

Y1 - 2008

N2 - Endemic pemphigus foliaceus (EPF) is an autoimmune disease, which occurs in Brazil and other regions of South America. Mannose-binding lectin (MBL) and MBL-associated serine protease (MASP-2) play a key role in innate immunity, and its deficiency has been related to increased susceptibility to infection and autoimmune diseases. MBL and MASP-2 serum levels were measured in 114 patients with EPF and in 100 healthy individuals in Brazil. MBL and MASP-2 levels were measured by sandwich assays (time-resolved immunofluorimetic assay) using monoclonal antibodies. No difference was observed in the MBL level in patients with EPF compared with controls [mean +/- SEM 1230.07 +/- 132.18 ng/mL (median 789.0 ng/mL) vs. 1036.98 +/- 117.99 ng/mL (median 559.5 ng/mL), P = 0.32]. Non-significant lower MASP-2 levels were observed in EPF [274.34 +/- 15.66 ng/mL (median 239.5 ng/mL ) vs. 304.72 +/- 15.28 ng/mL [median 261.0 ng/mL ), P = 0.06]. MBL deficiency (<10 ng/mL) or MASP-2 deficiency (<100 ng/mL) did not differ significantly between patients and controls. These data indicate that MBL and MASP-2 deficiency are not associated with susceptibility to EPF.

AB - Endemic pemphigus foliaceus (EPF) is an autoimmune disease, which occurs in Brazil and other regions of South America. Mannose-binding lectin (MBL) and MBL-associated serine protease (MASP-2) play a key role in innate immunity, and its deficiency has been related to increased susceptibility to infection and autoimmune diseases. MBL and MASP-2 serum levels were measured in 114 patients with EPF and in 100 healthy individuals in Brazil. MBL and MASP-2 levels were measured by sandwich assays (time-resolved immunofluorimetic assay) using monoclonal antibodies. No difference was observed in the MBL level in patients with EPF compared with controls [mean +/- SEM 1230.07 +/- 132.18 ng/mL (median 789.0 ng/mL) vs. 1036.98 +/- 117.99 ng/mL (median 559.5 ng/mL), P = 0.32]. Non-significant lower MASP-2 levels were observed in EPF [274.34 +/- 15.66 ng/mL (median 239.5 ng/mL ) vs. 304.72 +/- 15.28 ng/mL [median 261.0 ng/mL ), P = 0.06]. MBL deficiency (<10 ng/mL) or MASP-2 deficiency (<100 ng/mL) did not differ significantly between patients and controls. These data indicate that MBL and MASP-2 deficiency are not associated with susceptibility to EPF.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Complement Pathway, Classical

KW - Female

KW - Genotype

KW - Humans

KW - Male

KW - Mannose-Binding Lectin

KW - Mannose-Binding Protein-Associated Serine Proteases

KW - Middle Aged

KW - Pemphigus

U2 - 10.1111/j.1365-2230.2008.02743.x

DO - 10.1111/j.1365-2230.2008.02743.x

M3 - Journal article

C2 - 18498410

VL - 33

SP - 495

EP - 497

JO - Clinical and Experimental Dermatology. Supplement

JF - Clinical and Experimental Dermatology. Supplement

SN - 0966-3487

IS - 4

ER -