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Jens Christian Jensenius

Antithrombin 3. Protection against death after injection of thromboplastin

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Intravenous injection of autologous lipoprotein (thromboplastin) or thrombin produced a lethal, hemorrhagic syndrome in chicken embryos. The embryos could be protected from this fatal result by injection of antithrombin III, an alpha(2)-globulin (molecular weight 60,000 to 80,000) purified from human, bovine, and guinea pig blood. Heparin also protected the embryos, but other inhibitors were less protective.
Original languageEnglish
JournalScience
Volume166
Issue3904
Pages (from-to)517-8
Number of pages2
ISSN0036-8075
Publication statusPublished - 1969

    Research areas

  • Alpha-Globulins, Animals, Antithrombins, Blood Protein Electrophoresis, Cattle, Chick Embryo, Electrophoresis, Disc, Guinea Pigs, Hemorrhage, Heparin, Humans, Injections, Intravenous, Molecular Weight, Thromboplastin

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