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Jens Christian Jensenius

An insight into normal and pathological pregnancies using large-scale microarrays: lessons from microarrays

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Gérard Chaouat
  • ,
  • Nathalie Rodde
  • ,
  • Marie Petitbarat
  • ,
  • Roberta Bulla
  • ,
  • Mona Rahmati
  • ,
  • Sylvie Dubanchet
  • ,
  • Sandrine Zourbas
  • ,
  • Isabelle Bataillon
  • ,
  • Nathalie Coqué
  • ,
  • Benoit Hennuy
  • ,
  • Jacques Martal
  • ,
  • Carine Munaut
  • ,
  • Julie Aubert
  • ,
  • Valérie Sérazin
  • ,
  • Thiel Steffen
  • ,
  • Jens Christian Jensenius
  • Jean Michel Foidart
  • ,
  • Olivier Sandra
  • ,
  • Francesco Tedesco
  • ,
  • Nathalie Lédée
In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and large-scale microarrays in CBA × DBA/2 and CBA × BALB/c combinations, recently described as a murine model for preeclampsia. Our results are in line with other data suggesting a very early deregulation of local immune vascular events rather than a break of immune tolerance. Other data presented at the Tioman 2010 Preeclampsia Workshop supporting this hypothesis are briefly summarised, as well as indications and caveats from a recent human microarray on implantation failure and recurrent pregnancy loss.
Original languageEnglish
JournalJournal of Reproductive Immunology
Volume89
Issue2
Pages (from-to)163-72
Number of pages10
ISSN0165-0378
DOIs
Publication statusPublished - 2011

    Research areas

  • Animals, Disease Models, Animal, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Immune Tolerance, Male, Mice, Mice, Inbred BALB C, Mice, Inbred CBA, Mice, Inbred DBA, Oligonucleotide Array Sequence Analysis, Pre-Eclampsia, Pregnancy

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