Jan Asad

  1. 2019
  2. Published

    Translational control in brain pathologies : biological significance and therapeutic opportunities. / Delaidelli, Alberto; Jan, Asad; Herms, Jochen; Sorensen, Poul H.

    In: Acta Neuropathologica, Vol. 137, No. 4, 04.2019, p. 535-555.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  3. 2018
  4. Published

    Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity. / Jan, Asad; Jansonius, Brandon; Delaidelli, Alberto; Bhanshali, Forum; An, Yi Andy; Ferreira, Nelson; Smits, Lisa M; Negri, Gian Luca; Schwamborn, Jens C; Jensen, Poul H; Mackenzie, Ian R; Taubert, Stefan; Sorensen, Poul H.

    In: Acta Neuropathologica Communications, Vol. 6, No. 1, 54, 2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. 2017
  6. Published

    MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation. / Delaidelli, Alberto; Negri, Gian Luca; Jan, Asad; Jansonius, Brandon; El-Naggar, Amal; Lim, Jonathan K M; Khan, Debjit; Zarni Oo, Htoo; Carnie, Christopher J; Remke, Marc; Maris, John M; Leprivier, Gabriel; Sorensen, Poul H.

    In: Cell Death and Differentiation, Vol. 24, No. 9, 09.2017, p. 1564-1576.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. Published

    eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response. / Jan, Asad; Jansonius, Brandon; Delaidelli, Alberto; Somasekharan, Syam Prakash; Bhanshali, Forum; Vandal, Milène; Negri, Gian Luca; Moerman, Don; MacKenzie, Ian; Calon, Frédéric; Hayden, Michael R; Taubert, Stefan; Sorensen, Poul H.

    In: Acta Neuropathologica, Vol. 133, No. 1, 01.2017, p. 101-119.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. 2015
  9. Published

    Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression. [Corrected]. / Jan, Asad; Karasinska, Joanna M; Kang, Martin H; de Haan, Willeke; Ruddle, Piers; Kaur, Achint; Connolly, Colum; Leavitt, Blair R; Sorensen, Poul H; Hayden, Michael R.

    In: Neuroscience Letters, Vol. 598, 26.06.2015, p. 66-72.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. 2012
  11. Published

    Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation. / Kroth, Heiko; Ansaloni, Annalisa; Varisco, Yvan; Jan, Asad; Sreenivasachary, Nampally; Rezaei-Ghaleh, Nasrollah; Giriens, Valérie; Lohmann, Sophie; López-Deber, María Pilar; Adolfsson, Oskar; Pihlgren, Maria; Paganetti, Paolo; Froestl, Wolfgang; Nagel-Steger, Luitgard; Willbold, Dieter; Schrader, Thomas; Zweckstetter, Markus; Pfeifer, Andrea; Lashuel, Hilal A; Muhs, Andreas.

    In: The Journal of biological chemistry, Vol. 287, No. 41, 2012, p. 34786-800.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches. / Jan, Asad; Lashuel, Hilal A.

    In: Methods in molecular biology (Clifton, N.J.), Vol. 849, 2012, p. 227-43.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. 2011
  14. Published

    Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species. / Jan, Asad; Adolfsson, Oskar; Allaman, Igor; Buccarello, Anna-Lucia; Magistretti, Pierre J; Pfeifer, Andrea; Muhs, Andreas; Lashuel, Hilal A.

    In: The Journal of biological chemistry, Vol. 286, No. 10, 11.03.2011, p. 8585-96.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. 2010
  16. Published

    Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research. / Jan, Asad; Hartley, Dean M; Lashuel, Hilal A.

    In: Nature Protocols (Print), Vol. 5, No. 6, 06.2010, p. 1186-209.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. 2008
  18. Published

    The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity. / Jan, Asad; Gokce, Ozgun; Luthi-Carter, Ruth; Lashuel, Hilal A.

    In: Journal of Biological Chemistry, Vol. 283, No. 42, 2008, p. 28176-89.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review