Jan Asad

Postdoc

Profile photo

Jan Asad

Postdoc

  • Department of Biomedicine - Forskning og uddannelse, Vest
  • DANDRITE - Jensen Group
Postal address:
Ole Worms Allé 3
8000
Aarhus C
Denmark
Postal address:
Ole Worms Allé 3
1182, 226
8000
Aarhus C
Denmark

Email: ajan@dandrite.au.dk

Qualifications

Neuroscience, PhD, EPFL, Lausanne

1 Jul 200629 Jul 2010

Clinical Medicine, MBBS

30 Sep 200131 Oct 2004

Employment

Postdoc

Department of Biomedicine - Forskning og uddannelse, Vest

Aarhus University

Aarhus C, Denmark

11 Sep 2019 → present

Postdoc

DANDRITE - Jensen Group

Aarhus University

Aarhus C, Denmark

10 Nov 2019 → present

Postdoc

DANDRITE - Jensen Group

Aarhus University

Aarhus C, Denmark

2 Nov 201910 Nov 2019

Postdoc

DANDRITE - Jensen Group

Aarhus University

Aarhus C, Denmark

28 Sep 20172 Nov 2019

Postdoc

Aarhus Institute of Advanced Studies

Aarhus University

Aarhus C, Denmark

20 Sep 20171 Sep 2019

Postdoc

Department of Biomedicine - Forskning og uddannelse, Vest

Aarhus University

Aarhus C, Denmark

28 Sep 20171 Sep 2019

Postdoc

Aarhus Institute of Advanced Studies

Aarhus University

Aarhus C, Denmark

29 Aug 20175 Sep 2017

Publications

Translational control in brain pathologies: biological significance and therapeutic opportunities

Delaidelli, A., Jan, A., Herms, J. & Sorensen, P. H., Apr 2019, In : Acta Neuropathologica. 137, 4, p. 535-555 21 p.

Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

Jan, A., Jansonius, B., Delaidelli, A., Bhanshali, F., An, Y. A., Ferreira, N., Smits, L. M., Negri, G. L., Schwamborn, J. C., Jensen, P. H., Mackenzie, I. R., Taubert, S. & Sorensen, P. H., 2018, In : Acta Neuropathologica Communications. 6, 1, 17 p., 54.

MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation

Delaidelli, A., Negri, G. L., Jan, A., Jansonius, B., El-Naggar, A., Lim, J. K. M., Khan, D., Zarni Oo, H., Carnie, C. J., Remke, M., Maris, J. M., Leprivier, G. & Sorensen, P. H., Sep 2017, In : Cell Death and Differentiation. 24, 9, p. 1564-1576 13 p.

eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response

Jan, A., Jansonius, B., Delaidelli, A., Somasekharan, S. P., Bhanshali, F., Vandal, M., Negri, G. L., Moerman, D., MacKenzie, I., Calon, F., Hayden, M. R., Taubert, S. & Sorensen, P. H., Jan 2017, In : Acta Neuropathologica. 133, 1, p. 101-119 19 p.

Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression. [Corrected]

Jan, A., Karasinska, J. M., Kang, M. H., de Haan, W., Ruddle, P., Kaur, A., Connolly, C., Leavitt, B. R., Sorensen, P. H. & Hayden, M. R., 26 Jun 2015, In : Neuroscience Letters. 598, p. 66-72 7 p.

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation

Kroth, H., Ansaloni, A., Varisco, Y., Jan, A., Sreenivasachary, N., Rezaei-Ghaleh, N., Giriens, V., Lohmann, S., López-Deber, M. P., Adolfsson, O., Pihlgren, M., Paganetti, P., Froestl, W., Nagel-Steger, L., Willbold, D., Schrader, T., Zweckstetter, M., Pfeifer, A., Lashuel, H. A. & Muhs, A., 2012, In : The Journal of biological chemistry. 287, 41, p. 34786-800 15 p.

Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches

Jan, A. & Lashuel, H. A., 2012, In : Methods in molecular biology (Clifton, N.J.). 849, p. 227-43 17 p.

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

Jan, A., Adolfsson, O., Allaman, I., Buccarello, A-L., Magistretti, P. J., Pfeifer, A., Muhs, A. & Lashuel, H. A., 11 Mar 2011, In : The Journal of biological chemistry. 286, 10, p. 8585-96 12 p.

Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research

Jan, A., Hartley, D. M. & Lashuel, H. A., Jun 2010, In : Nature Protocols (Print). 5, 6, p. 1186-209 24 p.

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

Jan, A., Gokce, O., Luthi-Carter, R. & Lashuel, H. A., 2008, In : Journal of Biological Chemistry. 283, 42, p. 28176-89 14 p.

Press / Media

“Jekyll and Hyde” enzyme has potential for countering cancer and Alzheimer’s

Asad Jan

24/10/2016

1 Media contribution