Jakob Kirkegård

Long-term Survival Following Ablation of Colorectal Liver Metastases

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Introduction: Ablation of colorectal liver metastases (CRLM) in highly selected patients is an option with curative potential. Patient selection and the ablative technique have continued to improve over the years. This study assessed the trends in long-term survival after ablation of CRLM. Methods: We conducted a register-based cohort study of all patients with CRLM referred to ablative treatment by the multidisciplinary team for hepatic diseases at our institution between 2000 and 2014. Patient data used to calculate estimates of survival was retrieved using national registries. Patients were divided into three subgroups according to time of ablation (2000-2004; 2005-2009, and 2010-2014). Survival was defined as the time from the first ablation procedure until death, censoring or end of the follow-up period (December 31, 2015). Results: 741 CRLM ablations were performed in 444 patients. The estimated 5-year survival from first ablation procedure was for 2000-2004: 18.9% (95% CI: 10.7-28.8%); 2005-2009: 31.1% (95% CI: 24.3-38.2%); and 2010-2014: 53.3% (95% CI: 44.3-61.5%). Log rank test showed a statistically significant difference in the survival between the three subgroups (p < 0.001). Conclusion: Survival rates improved from 2000 to 2014 probably owing to multiple factors, including advances in ablation procedures, oncological therapy, and optimized patient selection.
Original languageEnglish
JournalJournal of Surgery
Volume6
Issue1
Pages (from-to)13-18
Number of pages6
ISSN2330-0930
Publication statusPublished - 5 Jan 2018

    Research areas

  • Survival, Ablation, Radiofrequency/RFA, Microwave/MWA, Colorectal Cancer, Liver Metastases

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