Jakob Kirkegård

High Age Increases the Risk of Complications and Reduces Survival Following Esophagectomy for Adenocarcinoma

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Introduction: The aim of the present study was to investigate the impact of high age and comorbidities in relation
to postoperative complications, mortality, and long-term survival in patients undergoing surgery for adenocarcinoma of the
esophagus and gastro-esophageal junction (GEJ). Methods: A cohort study of 557 patients operated for adenocarcinoma of the
esophagus and GEJ. Data were collected from a prospectively maintained database, the Danish National Patient Registry, and
medical records. Univariate and multivariate statistical models were used to analyze data after stratification for possible
confounders. Results: The incidence of postoperative complications increased in patients aged ≥ 75 years compared with
younger patients (OR: 1.57; 95% CI: 0.93-2.62) although not significant. However, testing for trend revealed a linear increase
with age for severe complications (p=0.005). Age ≥ 75 years was also associated with increased 90-day but not 30-day
mortality (HR: 5.05; 95% CI: 1.70-14.94 and HR: 3.47; 95% CI: 0.61-19.72 respectively). Overall survival decreased with
increasing age (p=0.036). Conclusion: We found high age as an independent risk factor for death within 90 days but not 30
days after surgery for adenocarcinoma of the esophagus and GEJ. The presence of co-morbidity seemed to increase the risk for
postoperative complications.
Original languageEnglish
JournalJournal of Surgery
Pages (from-to)1-7
Number of pages7
Publication statusPublished - 1 Feb 2018

    Research areas

  • Esphageal neoplasms, Adenocarcinoma, Aged, Esophagectomy, Survival

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