Jacob Horsager

2025

Sympathetic and parasympathetic subtypes of body-first Lewy body disease observed in postmortem tissue from prediagnostic individuals

Andersen, K. B., Krishnamurthy, A., Just, M. K., Van Den Berge, N., Skjærbæk, C., Horsager, J., Knudsen, K., Vogel, J. W., Toledo, J. B., Attems, J., Polvikoski, T., Saito, Y., Murayama, S. & Borghammer, P., 2025, (E-pub / Early view) In: Nature Neuroscience. 1255555.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Validation of a data-driven motion-compensated PET brain image reconstruction algorithm in clinical patients using four radiotracers

Munk, O. L., Rodell, A. B., Danielsen, P. B., Madsen, J. R., Sørensen, M. T., Okkels, N., Horsager, J., Andersen, K. B., Borghammer, P., Aanerud, J., Jones, J., Hong, I. & Zuehlsdorff, S., Dec 2025, In: EJNMMI Physics. 12, 1, 11.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2024

Brain-first vs. body-first Parkinson's disease: An update on recent evidence

Horsager, J. & Borghammer, P., May 2024, In: Parkinsonism & Related Disorders. 122, p. 106101 106101.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Open Access

26 Citations (Scopus)

Cholinergic changes in Lewy body disease: implications for presentation, progression and subtypes

Okkels, N., Grothe, M. J., Taylor, J.-P., Hasselbalch, S. G., Fedorova, T. D., Knudsen, K., van der Zee, S., van Laar, T., Bohnen, N., Borghammer, P. & Horsager, J., 1 Jul 2024, In: Brain. 147, 7, p. 2308-2324 17 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

13 Citations (Scopus)

Correlation between dopaminergic and metabolic asymmetry in Lewy body disease - A dual-imaging study

Horsager, J., Andersen, K. B., Okkels, N., Knudsen, K., Skjærbæk, C., Van Den Berge, N., Pavese, N., Gottrup, H. & Borghammer, P., Oct 2024, In: Parkinsonism & Related Disorders. 127, p. 107117 107117.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

1 Citation (Scopus)

Cortical hypometabolism in Parkinson’s disease is linked to cholinergic basal forebrain atrophy

Labrador-Espinosa, M. A., Silva-Rodriguez, J., Okkels, N., Muñoz-Delgado, L., Horsager, J., Castro-Labrador, S., Franco-Rosado, P., Castellano-Guerrero, A. M., Iglesias-Camacho, E., San-Eufrasio, M., Macías-García, D., Jesús, S., Adarmes-Gómez, A., Ojeda-Lepe, E., Carrillo, F., Martín-Rodríguez, J. F., Roldan Lora, F., García-Solís, D., Borghammer, P. & Mir, P. & 1 others, Grothe, M. J., 2024, (Accepted/In press) In: Molecular Psychiatry. 44.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

1 Citation (Scopus)

Impaired cholinergic integrity of the colon and pancreas in dementia with Lewy bodies

Okkels, N., Horsager, J., Fedorova, T. D., Knudsen, K., Skjærbæk, C., Andersen, K. B., Labrador-Espinosa, M., Vestergaard, K., Mortensen, J. K., Klit, H., Møller, M., Danielsen, E. H., Johnsen, E. L., Bekan, G., Hansen, K. V., Munk, O. L., Damholdt, M. F., Kjeldsen, P. L., Hansen, A. K. & Gottrup, H. & 2 others, Grothe, M. J. & Borghammer, P., 4 Jan 2024, In: Brain. 147, 1, p. 255-266 12 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

4 Citations (Scopus)

The Body, the Brain, the Environment, and Parkinson's Disease

Dorsey, E. R., De Miranda, B. R., Horsager, J. & Borghammer, P., 2024, In: Journal of Parkinson's Disease. 14, 3, p. 363-381 19 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Open Access

10 Citations (Scopus)

2023

Cholinergic Imaging and Dementia

Okkels, N., Horsager, J., Pavese, N., Brooks, D. J. & Borghammer, P., 1 Jan 2023, Molecular Imaging of Neurodegenerative Disorders. Springer International Publishing, p. 127-144 18 p.

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review

Distribution of Cholinergic Nerve Terminals in the Aged Human Brain Measured with [¹⁸F]FEOBV PET and its Correlation with Histological Data

Okkels, N., Horsager, J., Labrador-Espinosa, M. A., Hansen, F. O., Andersen, K. B., Just, M. K., Fedorova, T. D., Skjærbæk, C., Munk, O. L., Hansen, K. V., Gottrup, H., Hansen, A. K., Grothe, M. J. & Borghammer, P., Apr 2023, In: NeuroImage. 269, 13 p., 119908.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

14 Citations (Scopus)

Dopaminergic Dysfunction Is More Symmetric in Dementia with Lewy Bodies Compared to Parkinson's Disease

Fedorova, T. D., Knudsen, K., Horsager, J., Hansen, A. K., Okkels, N., Gottrup, H., Vang, K. & Borghammer, P., 13 Jun 2023, In: Journal of Parkinson's Disease. 13, 4, p. 515-523 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

12 Citations (Scopus)

Severe cholinergic terminal loss in newly diagnosed dementia with Lewy bodies

Okkels, N., Horsager, J., Labrador-Espinosa, M., Kjeldsen, P. L., Damholdt, M. F., Mortensen, J., Vestergård, K., Knudsen, K., Andersen, K. B., Fedorova, T. D., Skjærbæk, C., Gottrup, H., Hansen, A. K., Grothe, M. J. & Borghammer, P., 1 Sept 2023, In: Brain : a journal of neurology. 146, 9, p. 3690-3704 15 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

24 Citations (Scopus)

Synaptic Density and Glucose Consumption in Patients with Lewy Body Diseases: An [¹¹C]UCB-J and [¹⁸F]FDG PET Study

Andersen, K. B., Hansen, A. K., Schacht, A. C., Horsager, J., Gottrup, H., Klit, H., Danielsen, E. H., Poston, K. L., Pavese, N., Brooks, D. J. & Borghammer, P., May 2023, In: Movement disorders : official journal of the Movement Disorder Society. 38, 5, p. 796-805 10 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

18 Citations (Scopus)

3 Downloads (Pure)

Thyroid [¹²³I]MIBG uptake in Parkinson's disease and diabetes mellitus

Fedorova, T. D., Knudsen, K., Rasmussen, T. K., Horsager, J., Nahimi, A., Skjærbæk, C., Schaeffer, E., Berg, D., Terkelsen, A. J. & Borghammer, P., Jun 2023, In: IBRO Neuroscience Reports. 14, p. 342-345 4 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

1 Citation (Scopus)

2022

[ 18F]FEOBV positron emission tomography may not be a suitable method to measure parasympathetic denervation in patients with Parkinson's disease.

Horsager, J., Okkels, N., Fedorova, T. D., Knudsen, K., Skjærbæk, C., Van Den Berge, N., Jacobsen, J., Munk, O. L., Danielsen, E. H., Bender, D., Brooks, D. J. & Borghammer, P., Nov 2022, In: Parkinsonism & Related Disorders. 104, p. 21-25 5 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

3 Citations (Scopus)

A postmortem study suggests a revision of the dual-hit hypothesis of Parkinson's disease

Borghammer, P., Just, M. K., Horsager, J., Skjærbæk, C., Raunio, A., Kok, E. H., Savola, S., Murayama, S., Saito, Y., Myllykangas, L. & Van Den Berge, N., Dec 2022, In: npj Parkinson's Disease . 8, 1, 166.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

76 Citations (Scopus)

Clinical and imaging evidence of brain-first and body-first Parkinson's disease

Horsager, J., Knudsen, K. & Sommerauer, M., Mar 2022, In: Neurobiology of Disease. 164, 105626.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

78 Citations (Scopus)

Disruption of Sleep Microarchitecture Is a Sensitive and Early Marker of Parkinson's Disease

Doppler, C. E. J., Smit, J., Hommelsen, M., Seger, A., Okkels, N., Horsager, J., Kinnerup, M., Hansen, A. K., Fedorova, T. D., Knudsen, K., Otto, M., Nahimi, A., Fink, G. R., Borghammer, P. & Sommerauer, M., Dec 2022, In: Journal of Parkinson's Disease. 12, 8, p. 2555-2560 6 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2 Citations (Scopus)

Imaging progressive peripheral and central dysfunction in isolated REM sleep behaviour disorder after 3 years of follow-up

Fedorova, T. D., Knudsen, K., Andersen, K. B., Horsager, J., Skjærbæk, C., Beier, C. P., Sommerauer, M., Svendsen, K. B., Otto, M. & Borghammer, P., Aug 2022, In: Parkinsonism and Related Disorders. 101, p. 99-104 6 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

13 Citations (Scopus)

21 Downloads (Pure)

In vivo vesicular acetylcholine transporter density in human peripheral organs: an [ 18F]FEOBV PET/CT study.

Horsager, J., Okkels, N., Van Den Berge, N., Jacobsen, J., Schact, A., Munk, O. L., Vang, K., Bender, D., Brooks, D. J. & Borghammer, P., 1 Apr 2022, In: EJNMMI research. 12, 1, 17.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

6 Citations (Scopus)

Mapping Cholinergic Synaptic Loss in Parkinson's Disease: An [18F]FEOBV PET Case-Control Study

Horsager, J., Okkels, N., Hansen, A. K., Damholdt, M. F., Andersen, K. H., Fedorova, T. D., Munk, O. L., Danielsen, E. H., Pavese, N., Brooks, D. J. & Borghammer, P., Dec 2022, In: Journal of Parkinson's Disease. 12, 8, p. 2493-2506 14 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

23 Citations (Scopus)

2021

Asymmetric Dopaminergic Dysfunction in Brain-First versus Body-First Parkinson's Disease Subtypes

Knudsen, K., Fedorova, T. D., Horsager, J., Andersen, K. B., Skjærbæk, C., Berg, D., Schaeffer, E., Brooks, D. J., Pavese, N., Van Den Berge, N. & Borghammer, P., Oct 2021, In: Journal of Parkinson's Disease. 11, 4, p. 1677-1687 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

52 Citations (Scopus)

Fasting gallbladder volume is increased in patients with Parkinson's disease

Horsager, J., Tiroke, L. H., Skjærbæk, C., Knudsen, K., Fedorova, T. D., Okkels, N. & Borghammer, P., Jun 2021, In: Parkinsonism & Related Disorders. 87, p. 56-60 5 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

5 Citations (Scopus)

53 Downloads (Pure)

Gastrointestinal Dysfunction in Parkinson’s Disease

Skjærbæk, C., Knudsen, K., Horsager, J. & Borghammer, P., 1 Feb 2021, In: Journal of Clinical Medicine. 10, 3, p. 1-17 17 p., 493.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Open Access

46 Citations (Scopus)

Microsleep disturbances are associated with noradrenergic dysfunction in Parkinson's disease

Doppler, C. E. J., Smit, J. A. M., Hommelsen, M., Seger, A., Horsager, J., Kinnerup, M. B., Hansen, A. K., Fedorova, T. D., Knudsen, K., Otto, M., Nahimi, A., Borghammer, P. & Sommerauer, M., Aug 2021, In: Sleep. 44, 8, 7 p., zsab040.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

24 Citations (Scopus)

Neuropathological evidence of body-first vs. brain-first Lewy body disease

Borghammer, P., Horsager, J., Andersen, K., Van Den Berge, N., Raunio, A., Murayama, S., Parkkinen, L. & Myllykangas, L., Dec 2021, In: Neurobiology of Disease. 161, 10 p., 105557.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

121 Citations (Scopus)

Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis

Kjærgaard, K., Frisch, K., Sørensen, M., Munk, O. L., Hofmann, A. F., Horsager, J., Schacht, A. C., Erickson, M., Shapiro, D. A. & Keiding, S., Jan 2021, In: Journal of Hepatology. 74, 1, p. 58-65 8 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

64 Citations (Scopus)

88 Downloads (Pure)

Prodromal Parkinson disease subtypes - key to understanding heterogeneity

Berg, D., Borghammer, P., Fereshtehnejad, S.-M., Heinzel, S., Horsager, J., Schaeffer, E. & Postuma, R. B., Jun 2021, In: Nature Reviews. Neurology. 17, 6, p. 349-361 13 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

224 Citations (Scopus)

Radionuclide imaging of the gut-brain axis in Parkinson disease

Horsager, J., Knudsen, K. & Borghammer, P., Nov 2021, In: Journal of Nuclear Medicine. 62, 11, p. 1504-1505 2 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

1 Citation (Scopus)

Reduced Synaptic Density in Patients with Lewy Body Dementia: An [¹¹C-]UCB-J PET Imaging Study

Andersen, K. B., Hansen, A. K., Damholdt, M. F., Horsager, J., Skjaerbaek, C., Gottrup, H., Klit, H., Schacht, A. C., Danielsen, E. H., Brooks, D. J. & Borghammer, P., Sept 2021, In: Movement Disorders. 36, 9, p. 2057-2065 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

52 Citations (Scopus)

The Logic and Pitfalls of Parkinson's as Brain- Versus Body-First Subtypes

Borghammer, P. & Horsager, J., Mar 2021, In: Movement Disorders. 36, 3, p. 785-786 2 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review

6 Citations (Scopus)

Vagus Nerve Cross-Sectional Area in Patients With Parkinson's Disease-An Ultrasound Case-Control Study

Horsager, J., Walter, U., Fedorova, T. D., Andersen, K. B., Skjærbæk, C., Knudsen, K., Okkels, N., von Weitzel-Mudersbach, P., Dyrskog, S. E., Bergholt, B. & Borghammer, P., 22 Jun 2021, In: Frontiers in Neurology. 12, 681413.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

14 Citations (Scopus)

2020

Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study

Horsager, J., Andersen, K. B., Knudsen, K., Skjærbæk, C., Fedorova, T. D., Okkels, N., Schaeffer, E., Bonkat, S. K., Geday, J., Otto, M., Sommerauer, M., Danielsen, E. H., Bech, E., Kraft, J., Munk, O. L., Hansen, S. D., Pavese, N., Göder, R., Brooks, D. J. & Berg, D. & 1 others, Borghammer, P., 1 Oct 2020, In: Brain. 143, 10, p. 3077-3088 12 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

484 Citations (Scopus)

2019

"Brain-first" vs. "body-first" Parkinson's disease is determined by RBD-status - a multi-modality imaging study

Horsager, J., Knudsen, K., Andersen, K., Skjaerbaek, C., Fedorova, T., Geday, J., Kraft, J., Bech, E., Danielsen, E., Moller, M., Pavese, N., Brooks, D. & Borghammer, P., 2019, In: Movement Disorders. 34, S2, p. S796-S796 1 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research › peer-review

Cardiac ¹¹ C-Donepezil Binding Increases With Age in Healthy Humans: Potentially Signifying Sigma-1 Receptor Upregulation

Horsager, J., Fedorova, T. D., Berge, N. A. E. V. D., Klinge, M. W., Knudsen, K., Hansen, A., Alstrup, A. K. O., Krogh, K., Gormsen, L. C. & Borghammer, P., 1 Jul 2019, In: Journal of Cardiovascular Pharmacology and Therapeutics. 24, 4, p. 365-370 6 p., 1074248419838509.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

8 Citations (Scopus)

Esophageal transit and intestinal dysfunction in Parkinson’s disease

Skjærbæk, C., Knudsen, K., Horsager, J. & Borghammer, P., 21 Mar 2019.

Research output: Contribution to conference › Poster › Research

Esophageal transit and intestinal dysfunction in Parkinson’s disease

Skjærbæk, C., Knudsen, K., Horsager, J. & Borghammer, P., 13 May 2019.

Research output: Contribution to conference › Poster › Research

Human biodistribution, dosimetry, radiosynthesis and quality control of the bile acid PET tracer [N-methyl-11C]cholylsarcosine

Frisch, K., Kjærgaard, K., Horsager, J., Schacht, A. C. & Munk, O. L., Jun 2019, In: Nuclear Medicine and Biology. 72-73, May-June, p. 55-61 7 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

7 Citations (Scopus)

Obeticholic acid improves hepatobiliary excretion of bile acids in patients with PBC

Kjærgaard, K., Frisch, K., Munk, O. L., Hofmann, A. F., Sørensen, M., Horsager, J., Erickson, M., Shapiro, D. A. & Keiding, S., 9 Nov 2019.

Research output: Contribution to conference › Poster › Research › peer-review

Prognostic modeling for patients with colorectal liver metastases incorporating FDG PET radiomic features

Rahmim, A., Bak-Fredslund, K. P., Ashrafinia, S., Lu, L., Schmidtlein, C. R., Subramaniam, R. M., Morsing, A., Keiding, S., Horsager, J. & Munk, O. L., 2019, In: European Journal of Radiology. 113, April, p. 101-109 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

46 Citations (Scopus)

2017

Hepatic metabolism of 11C-methionine and secretion of 11C-protein measured by PET in pigs

Horsager, J., Lausten, S. B., Bender, D., Munk, O. L. & Keiding, S., 1 Sept 2017, In: American Journal of Nuclear Medicine and Molecular Imaging. 7, 4, p. 167-173 7 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2016

Optimal 2-[(18)F]fluoro-2-deoxy-D-galactose PET/CT protocol for detection of hepatocellular carcinoma

Horsager, J., Bak-Fredslund, K., Larsen, L. P. S., Villadsen, G. E., Bogsrud, T. V. & Sørensen, M., 1 Dec 2016, In: EJNMMI research. 6, 1, p. 56 56.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

12 Citations (Scopus)

2015

Metabolic liver function measured in vivo by dynamic (18)F-FDGal PET/CT without arterial blood sampling

Nielsen, J. H., Munk, O. L. & Sørensen, M., 2015, In: EJNMMI research. 5, p. 32

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

11 Citations (Scopus)

Jacob Horsager

Research output

Search results