Jacob Giehm Mikkelsen

  1. 2021
  2. Published

    Targeted Knockout of the Vegfa Gene in the Retina by Subretinal Injection of RNP Complexes Containing Cas9 Protein and Modified sgRNAs. / Holmgaard, Andreas Braae; Askou, Anne Louise; Jensen, Emilie Grarup; Alsing, Sidsel; Bak, Rasmus O; Mikkelsen, Jacob Giehm; Corydon, Thomas J.

    In: Molecular Therapy, Vol. 29, No. 1, 01.2021, p. 191-207.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. 2020
  4. Published

    Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans. / Hait, Alon Schneider; Olagnier, David; Sancho-Shimizu, Vanessa; Skipper, Kristian Alsbjerg; Helleberg, Marie; Larsen, Simon Muller; Bodda, Chiranjeevi; Moldovan, Liviu Ionut; Ren, Fanghui; Brinck Andersen, Nanna-Sophie; Thomsen, Michelle M; Freytag, Mette Ratzer; Darmalinggam, Sathya; Parkes, Isobel; Kadekar, Darshana D; Rahbek, Stine Hess; van der Horst, Demi; Kristensen, Lasse Sommer; Eriksson, Kristina; Kjems, Jørgen; Mostowy, Serge; Christiansen, Mette; Mikkelsen, Jacob Giehm; Brandt, Christian Thomas; Paludan, Søren R; Mogensen, Trine H.

    In: Science Immunology, Vol. 5, No. 54, eabc2691, 12.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization. / Dalskov, Louise; Narita, Ryo; Andersen, Line L.; Jensen, Nanna; Assil, Sonia; Kristensen, Kennith H.; Mikkelsen, Jacob G.; Fujita, Takashi; Mogensen, Trine H.; Paludan, Søren R.; Hartmann, Rune.

    In: Nucleic Acids Research, Vol. 48, No. 20, 11.2020, p. 11421-11433.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. Published

    MicroRNA-106b Regulates Expression of the Tumour Suppressors p21 and TXNIP and Promotes Tumour Cell Proliferation in Mycosis Fungoides. / Lindahl, Lise M; Gluud, Maria; Emmanuel, Thomas; Thomsen, Emil A; Hu, Tengpeng; Rittig, Anne H; Celis, Pamela; Stolearenco, Veronica; Krejsgaard, Thorbjørn; Johansen, Claus; Willerslev-Olsen, Andreas; Buus, Terkild B; Woetmann, Anders; Aagaard, Lars; Geisler, Carsten; Litman, Thomas; Mikkelsen, Jacob G; Odum, Niels; Iversen, Lars.

    In: Acta Dermato-Venereologica, Vol. 100, adv00270, 09.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. E-pub ahead of print
  8. Published

    Identification of BLNK and BTK as mediators of rituximab-induced programmed cell death by CRISPR screens in GCB-subtype diffuse large B-cell lymphoma. / Thomsen, Emil Aagaard; Rovsing, Anne Bruun; Anderson, Mads Valdemar; Due, Hanne; Huang, Jinrong; Luo, Yonglun; Dybkaer, Karen; Mikkelsen, Jacob Giehm.

    In: Molecular Oncology, Vol. 14, No. 9, 2020, p. 1978-1997.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. 2019
  10. Published

    Sustained transgene expression from sleeping beauty DNA transposons containing a core fragment of the HNRPA2B1-CBX3 ubiquitous chromatin opening element (UCOE). / Skipper, Kristian Alsbjerg; Hollensen, Anne Kruse; Antoniou, Michael N; Mikkelsen, Jacob Giehm.

    In: BMC Biotechnology, Vol. 19, No. 1, 75, 09.11.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy. / Askou, Anne Louise; Alsing, Sidsel; Benckendorff, Josephine N.E.; Holmgaard, Andreas; Mikkelsen, Jacob Giehm; Aagaard, Lars; Bek, Toke; Corydon, Thomas J.

    In: Molecular Therapy - Nucleic Acids, Vol. 16, 07.06.2019, p. 38-50.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    MicroRNA-155 controls vincristine sensitivity and predicts superior clinical outcome in diffuse large B-cell lymphoma. / Due, Hanne; Schönherz, Anna Amanda; Ryø, Laura; Primo, Maria Nascimento; Jespersen, Ditte Starberg; Thomsen, Emil Aagaard; Roug, Anne Stidholt; Xiao, Min; Tan, Xiaohong; Pang, Yuyang; Young, Ken H; Bøgsted, Martin; Mikkelsen, Jacob Giehm; Dybkær, Karen.

    In: Blood Advances, Vol. 3, No. 7, 09.04.2019, p. 1185-1196.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Dominant negative SERPING1 variants cause intracellular retention of C1-inhibitor in hereditary angioedema. / Haslund, Didde; Ryø, Laura Barrett; Majidi, Sara Seidelin; Christiansen, Iben Rose; Skipper, Kristian Alsbjerg; Fryland, Tue; Bohn, Anja Bille; Koch, Claus; Thomsen, Martin Kristian; Palarasah, Yaseelan; Corydon, Thomas Juhl; Bygum, Anette; Nejsum, Lene Niemann; Mikkelsen, Jacob Giehm.

    In: Journal of Clinical Investigation, Vol. 129, No. 1, CI98869, 2019, p. 388-405.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. 2018
  15. Published

    Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs. / Hollensen, Anne Kruse; Andersen, Sofie; Hjorth, Karina; Bak, Rasmus O; Hansen, Thomas B; Kjems, Jørgen; Aagaard, Lars; Damgaard, Christian Kroun; Mikkelsen, Jacob Giehm.

    In: Molecular Therapy - Nucleic Acids, Vol. 13, 07.12.2018, p. 365-375.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    Viral delivery of genome-modifying proteins for cellular reprogramming. / Mikkelsen, Jacob Giehm.

    In: Current Opinion in Genetics & Development, Vol. 52, 10.2018, p. 92-99.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  17. Published

    Retroviruses in Human Gene Therapy. / Pedersen, Finn Skou; Mikkelsen, Jacob Giehm.

    In: Encyclopedia of Life Sciences, 17.09.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleCommunication

  18. Published

    Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein. / Dalsgaard, Trine; Kaadt, Claudia Regina Cecchi; Askou, Anne Louise; Bak, Rasmus O; Andersen, Pernille O; Hougaard, David; Jensen, Thomas G; Dagnæs-Hansen, Frederik; Mikkelsen, Jacob Giehm; Corydon, Thomas J; Aagaard, Lars.

    In: Molecular Therapy - Nucleic Acids, Vol. 12, 07.09.2018, p. 672-683.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. Published

    Time-Restricted PiggyBac DNA Transposition by Transposase Protein Delivery Using Lentivirus-Derived Nanoparticles. / Skipper, Kristian Alsbjerg; Nielsen, Mathias Gaarde; Andersen, Sofie; Ryø, Laura Barrett; Bak, Rasmus O; Mikkelsen, Jacob Giehm.

    In: Molecular Therapy - Nucleic Acids, Vol. 11, 01.06.2018, p. 253-262.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. Published

    Defective RNA sensing by RIG-I in severe influenza virus infection. / Jørgensen, Sofie Eg; Christiansen, Mette; Ryø, Laura Barrett; Gad, Hans Henrik; Gjedsted, Jakob; Staeheli, Peter; Mikkelsen, Jacob Giehm; Storgaard, Merete; Hartmann, Rune; Mogensen, Trine Hyrup.

    In: Clinical and Experimental Immunology, Vol. 192, No. 3, 06.2018, p. 366-376.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. 2017
  22. Published

    In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells. / Holmgaard, Andreas; Askou, Anne Louise; Benckendorff, Josephine Natalia Esther; Thomsen, Emil Aagaard; Cai, Yujia; Bek, Toke; Mikkelsen, Jacob Giehm; Corydon, Thomas J.

    In: Molecular Therapy - Nucleic Acids, Vol. 9, 15.12.2017, p. 89-99.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections. / Ogunjimi, Benson; Zhang, Shen-Ying; Sørensen, Katrine Biehl; Skipper, Kristian A; Carter-Timofte, Madalina; Kerner, Gaspard; Luecke, Stefanie; Prabakaran, Thaneas; Cai, Yujia; Meester, Josephina; Bartholomeus, Esther; Bolar, Nikhita Ajit; Vandeweyer, Geert; Claes, Charlotte; Sillis, Yasmine; Lorenzo, Lazaro; Fiorenza, Raffaele A; Boucherit, Soraya; Dielman, Charlotte; Heynderickx, Steven; Elias, George; Kurotova, Andrea; Auwera, Ann Vander; Verstraete, Lieve; Lagae, Lieven; Verhelst, Helene; Jansen, Anna; Ramet, Jose; Suls, Arvid; Smits, Evelien; Ceulemans, Berten; Van Laer, Lut; Plat Wilson, Genevieve; Kreth, Jonas; Picard, Capucine; Von Bernuth, Horst; Fluss, Joël; Chabrier, Stephane; Abel, Laurent; Mortier, Geert; Fribourg, Sebastien; Mikkelsen, Jacob Giehm; Casanova, Jean-Laurent; Paludan, Søren R; Mogensen, Trine H.

    In: Journal of Clinical Investigation, 01.09.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    Improved microRNA suppression by WPRE-linked Tough Decoy microRNA sponges. / Hollensen, Anne Kruse; Thomsen, Rune; Bak, Rasmus O; Petersen, Charlotte Christie; Ermegaard, Eva Reumert; Aagaard, Lars; Damgaard, Christian Kroun; Mikkelsen, Jacob Giehm.

    In: RNA, Vol. 23, No. 8, 08.2017, p. 1247-1258.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    Suppression of Choroidal Neovascularization in Mice by Subretinal Delivery of Multigenic Lentiviral Vectors Encoding Anti-Angiogenic MicroRNAs. / Askou, Anne Louise; Benckendorff, Josephine Natalia Esther; Holmgaard, Andreas; Storm, Tina; Aagaard, Lars; Bek, Toke; Mikkelsen, Jacob Giehm; Corydon, Thomas Juhl.

    In: Human Gene Therapy. Methods, Vol. 28, No. 4, 08.2017, p. 222-233.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Published

    Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1. / Staunstrup, Nicklas Heine; Stenderup, Karin; Mortensen, Sidsel; Nascimento Primo, Maria; Rosada, Cecilia; Steiniche, Torben; Liu, Ying; Li, Rong; Schmidt, Mette; Purup, Stig; Dagnæs-Hansen, Frederik; Schrøder, Lisbeth Dahl; Svensson, Lars; Petersen, Thomas Kongstad; Callesen, Henrik; Bolund, Lars; Mikkelsen, Jacob Giehm.

    In: Disease Models & Mechanisms, Vol. 10, 01.07.2017, p. 869-880.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. Published

    IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. / Jønsson, K L; Laustsen, A; Krapp, C; Skipper, K A; Thavachelvam, K; Hotter, D; Egedal, J H; Kjolby, M; Mohammadi, P; Prabakaran, T; Sørensen, L K; Sun, C; Jensen, S B; Holm, C K; Lebbink, Robert Jan; Johannsen, M; Nyegaard, M; Mikkelsen, J G; Kirchhoff, F; Paludan, S R; Jakobsen, M R.

    In: Nature Communications, Vol. 8, 14391, 10.02.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. 2016
  29. Published

    Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection. / Thomsen, Martin K; Nandakumar, Ramya; Stadler, Daniela; Malo, Antje; Valls, Roser Marin; Wang, Fan; Reinert, Line S; Dagnaes-Hansen, Frederik; Hollensen, Anne Kruse; Mikkelsen, Jacob Giehm; Protzer, Ulrike; Paludan, Søren R.

    In: Hepatology, Vol. 64, No. 3, 16.06.2016, p. 746-759.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. Published

    Anti-Apoptotic Effects of Lentiviral Vector Transduction Promote Increased Rituximab Tolerance in Cancerous B-Cells. / Ranjbar, Ben; Krogh, Louise; Laursen, Maria Bach; Primo, Maria Nascimento; Marques, Sara Correia; Dybkær, Karen; Mikkelsen, Jacob Giehm.

    In: PLOS ONE, Vol. 11, No. 4, 05.04.2016, p. e0153069.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. Published

    Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses. / Holm, Christian K; Rahbek, Stine H; Gad, Hans Henrik; Bak, Rasmus O; Jakobsen, Martin R; Jiang, Zhaozaho; Hansen, Anne Louise; Jensen, Simon K; Sun, Chenglong; Thomsen, Martin K; Laustsen, Anders; Nielsen, Camilla G; Severinsen, Kasper; Xiong, Yingluo; Burdette, Dara L; Hornung, Veit; Lebbink, Robert Jan; Duch, Mogens; Fitzgerald, Katherine A; Bahrami, Shervin; Mikkelsen, Jacob Giehm; Hartmann, Rune; Paludan, Søren R.

    In: Nature Communications, Vol. 7, 10680, 19.02.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. Published

    High miR-34a expression improves response to doxorubicin in diffuse large B-cell lymphoma. / Marques, Sara Correia; Ranjbar, Ben; Laursen, Maria Bach; Falgreen, Steffen; Bilgrau, Anders Ellern; Bødker, Julie Støve; Jørgensen, Laura Krogh; Primo, Maria Nascimento; Schmitz, Alexander; Ettrup, Marianne Schmidt; Johnsen, Hans Erik; Bøgsted, Martin; Mikkelsen, Jacob Giehm; Dybkær, Karen.

    In: Experimental Hematology, 17.02.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. Published

    Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors. / Cai, Yujia; Laustsen, Anders; Zhou, Yan; Sun, Chenglong; Anderson, Mads Valdemar; Li, Shengting; Uldbjerg, Niels; Luo, Yonglun; Jakobsen, Martin R; Mikkelsen, Jacob Giehm.

    In: eLife, Vol. 5, 2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. 2015
  35. Published

    Efficient in vivo gene transfer to xenotransplanted human skin by lentivirus-mediated, but not by AAV-directed, gene delivery. / Jakobsen, Maria Vad; Askou, Anne Louise; Dokkedahl, Karin Stenderup; Kjeldsen, Cecilia Rosada; Dagnæs-Hansen, Frederik; Jensen, Thomas G.; Corydon, Thomas Juhl; Mikkelsen, Jacob Giehm; Aagaard, Lars.

    2015. Poster session presented at Annual Congress The European Society of Gene and Cell Therapy (ESGCT), Helsinki, Finland.

    Research output: Contribution to conferencePosterResearchpeer-review

  36. Published

    Robust Lentiviral Gene Delivery But Limited Transduction Capacity of Commonly Used Adeno-Associated Viral Serotypes in Xenotransplanted Human Skin. / Jakobsen, Maria; Askou, Anne Louise; Stenderup, Karin; Rosada, Cecilia; Dagnæs-Hansen, Frederik; Jensen, Thomas G; Corydon, Thomas J; Mikkelsen, Jacob Giehm; Aagaard, Lars.

    In: Human Gene Therapy. Methods, Vol. 26, No. 4, 08.2015, p. 123-33.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  37. Published
  38. Published

    Overexpression of MicroRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus. / Rasmussen, Tue Kruse; Andersen, Thomas; Bak, Rasmus Otkjær; Yiu, Gloria; Sørensen, Christian; Stengaard-Pedersen, Kristian; Mikkelsen, Jacob Giehm; Utz, Paul Joseph; Holm, Christian Kanstrup; Deleuran, Bent.

    In: Arthritis research & therapy, Vol. 17, No. 1, 154, 09.06.2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  39. Published

    Functional IRF3 deficiency in a patient with herpes simplex encephalitis. / Andersen, Line Lykke; Mørk, Nanna; Reinert, Line S; Kofod-Olsen, Emil; Narita, Ryo; Jørgensen, Sofie E; Skipper, Kristian A; Höning, Klara; Gad, Hans Henrik; Østergaard, Lars; Ørntoft, Torben F; Hornung, Veit; Paludan, Søren R; Mikkelsen, Jacob Giehm; Fujita, Takashi; Christiansen, Mette; Hartmann, Rune; Mogensen, Trine H.

    In: Journal of Experimental Medicine, Vol. 212, No. 9, 2015, p. 1371-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors. / Askou, Anne Louise; Aagaard, Lars; Kostic, Corinne; Arsenijevic, Yvan; Hollensen, Anne Kruse; Bek, Toke; Jensen, Thomas G.; Mikkelsen, Jacob Giehm; Corydon, Thomas Juhl.

    In: Molecular therapy. Methods & clinical development, Vol. 2, 2015, p. 14064.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  41. 2014
  42. Published

    Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases. / Cai, Yujia; Bak, Rasmus; Mikkelsen, Jacob Giehm.

    In: eLife, Vol. 3, 24.04.2014, p. e01911.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. Published

    Induction of Atherosclerosis in Mice and Hamsters Without Germline Genetic Engineering. / Bjørklund, Martin Mæng; Hollensen, Anne K; Hagensen, Mette K; Dagnaes-Hansen, Frederik; Christoffersen, Christina; Mikkelsen, Jacob G; Bentzon, Jacob F.

    In: Circulation Research, 27.03.2014.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. Published

    Integration-deficient lentiviral vectors as gene delivery vehicles for treatment of AMD. / Askou, Anne Louise; Hebsgaard Holm-Nielsen, Maria; Jensen, Thomas G.; Aagaard, Lars; Mikkelsen, Jacob Giehm; Corydon, Thomas Juhl.

    2014. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Versailles, France.

    Research output: Contribution to conferencePosterResearchpeer-review

  45. 2013
  46. Published

    miRNA sponges: soaking up miRNAs for regulation of gene expression. / Bak, Rasmus; Mikkelsen, Jacob Giehm.

    In: Wiley Interdisciplinary Reviews: RNA, 23.12.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  47. Published

    DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors. / Cai, Yujia; Bak, Rasmus O.; Krogh, Louise Bechmann; Staunstrup, Nicklas H; Moldt, Brian; Corydon, Thomas J; Schrøder, Lisbeth Dahl; Mikkelsen, Jacob Giehm.

    In: Nucleic Acids Research, 21.11.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  48. Published

    Integrase-defective lentiviral vectors-a stage for nonviral integration machineries. / Staunstrup, Nicklas Heine; Mikkelsen, Jacob Giehm.

    In: Current Gene Therapy, 05.11.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  49. Published

    DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors. / Cai, Yujia; Bak, Rasmus O.; Krogh, Louise B.; Staunstrup, Nicklas Heine; Moldt, Brian; Corydon, Thomas Juhl; Schrøder, Lisbeth Dahl; Mikkelsen, Jacob Giehm.

    2013. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Madrid, Spain.

    Research output: Contribution to conferencePosterResearch

  50. Published

    MicroRNA inhibition by dual-targeting and clustered Tough Decoy inhibitors. / Hollensen, Anne Kruse; Bak, Rasmus O.; Haslund, Didde; Mikkelsen, Jacob Giehm.

    2013. Abstract from Annual Congress of the European Society of Gene and Cell Therapy, Madrid, Spain.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  51. Published

    Multigenic lentiviral vectors for anti-angiogenic treatment of age-related macular degeneration (AMD). / Askou, Anne Louise; Aagaard, Lars; Kostic, Corinne; Arsenijevic, Yvan; Bek, Toke; Jensen, Thomas G.; Mikkelsen, Jacob Giehm; Corydon, Thomas Juhl.

    2013. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Madrid, Spain.

    Research output: Contribution to conferencePosterResearch

  52. Published

    Targeted genome editing by lentiviral protein transduction of zinc‐finger and TAL‐effector nucleases. / Cai, Yujia; Bak, Rasmus O.; Mikkelsen, Jacob Giehm.

    2013. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Madrid, Spain.

    Research output: Contribution to conferencePosterResearch

  53. Published

    IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. / Jakobsen, Martin Roelsgaard; Bak, Rasmus O; Andersen, Annika; Berg, Randi K; Jensen, Søren B; Tengchuan, Jin; Laustsen, Anders; Hansen, Kathrine; Ostergaard, Lars; Fitzgerald, Katherine A; Xiao, T Sam; Mikkelsen, Jacob G; Mogensen, Trine H; Paludan, Søren R.

    In: Proceedings of the National Academy of Sciences of the United States of America, 23.10.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  54. Published
  55. Published

    Managing MicroRNAs with Vector-Encoded Decoy-Type Inhibitors. / Bak, Rasmus Otkjær; Hollensen, Anne Kruse; Mikkelsen, Jacob Giehm.

    In: Molecular Therapy, Vol. 21, No. 8, 08.2013, p. 1478-85.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  56. Published

    A lentiviral vector-based genetic sensor system for comparative analysis of permeability and activity of vitamin D3 analogues in xenotransplanted human skin. / Staunstrup, Nicklas Heine; Bak, Rasmus Otkjær; Cai, Yujia; Svensson, Lars; Petersen, Anette Thomas; Rosada, Cecilia; Stenderup, Karin; Bolund, Lars; Mikkelsen, Jacob Giehm.

    In: Experimental Dermatology, Vol. 22, No. 3, 22.03.2013, p. 178-83.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  57. Published

    Efficient sleeping beauty DNA transposition from DNA minicircles. / Sharma, Nynne; Cai, Yujia; Bak, Rasmus O; Jakobsen, Martin Roelsgaard; Schrøder, Lisbeth Dahl; Mikkelsen, Jacob Giehm.

    In: Molecular Therapy - Nucleic Acids, Vol. 2, 2013, p. e74.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  58. Published

    Epigenetic marking and repression of porcine endogenous retroviruses. / Wolf, Gernot; Mikkelsen, Jacob Giehm; Nielsen, Anders Lade; Pedersen, Finn Skou.

    In: Journal of General Virology, Vol. 94, No. 5, 2013, p. 960- 970.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  59. Published

    Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant. / Al-Mashhadi, Rozh H; Sørensen, Charlotte B; Kragh, Peter M; Christoffersen, Christina; Mortensen, Martin B; Tolbod, Lars P; Thim, Troels; Du, Yutao; Li, Juan; Liu, Ying; Moldt, Brian; Schmidt, Mette; Vajta, Gabor; Larsen, Torben; Purup, Stig; Bolund, Lars; Nielsen, Lars B; Callesen, Henrik; Falk, Erling; Mikkelsen, Jacob Giehm; Bentzon, Jacob F.

    In: Science Translational Medicine, Vol. 5, No. 166, 2013, p. 166ra1.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  60. Published

    Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT). / Jakobsen, Jannik Ejnar; Johansen, Marianne G; Schmidt, Mette; Dagnæs-Hansen, Frederik; Dam, Karen; Gunnarsson, Anders; Liu, Ying; Kragh, Peter M; Li, Rong; Holm, Ida E; Callesen, Henrik; Mikkelsen, Jacob Giehm; Nielsen, Anders Lade; Jørgensen, Arne Lund.

    In: Transgenic Research, Vol. 22, 2013, p. 709-723.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  61. Published

    Inhibition of p53-dependent, but not p53-independent, cell death by U19 protein from human herpesvirus 6B. / Kofod-Olsen, Emil; Møller, Janni Michelle; Schleimann, Mariane Høgsbjerg; Bundgaard, Bettina; Bak, Rasmus Otkjær; Øster, Bodil; Mikkelsen, Jacob Giehm; Hupp, Ted; Höllsberg, Per.

    In: P L o S One, Vol. 8, No. e59223, 2013, p. 1-11.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  62. Published

    Potent microRNA suppression by RNA Pol II-transcribed 'Tough Decoy' inhibitors. / Bak, Rasmus Otkjær; Hollensen, Anne Kruse; Primo, Maria Nascimento; Sørensen, Camilla Darum; Mikkelsen, Jacob Giehm.

    In: RNA, Vol. 19, No. 2, 2013, p. 280-293.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  63. Published

    Suppression of microRNAs by dual-targeting and clustered Tough Decoy inhibitors. / Hollensen, Anne Kruse; Bak, Rasmus Otkjær; Haslund, Didde; Mikkelsen, Jacob Giehm.

    In: RNA Biology, Vol. 10, No. 3, 2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  64. 2012
  65. Published

    Potent microRNA suppression by RNA Pol II-transcribed Tough Decoy inhibitors. / Bak, Rasmus Otkjær; Hollensen, Anne Kruse; Nascimento Primo, Maria; Sørensen, Camilla Darum; Haslund, Didde; Mikkelsen, Jacob Giehm.

    2012. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Versailles, France.

    Research output: Contribution to conferencePosterResearch

  66. Published

    The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells. / Sharma, Nynne; Hollensen, Anne Kruse; Bak, Rasmus Otkjær; Staunstrup, Nicklas Heine; Schrøder, Lisbeth Dahl; Mikkelsen, Jacob Giehm.

    In: PLOS ONE, 10.07.2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  67. Published

    Variable Potency and Transfer Efficiency of Lentivirus-Encoded miRNA Inhibitors. / Bak, Rasmus Otkjær; Hollensen, Anne Kruse; Primo, Maria Do Nascimento Lopes; Mikkelsen, Jacob Giehm.

    2012. Poster session presented at Keystone Symposia, Santa Fe, New Mexico, United States.

    Research output: Contribution to conferencePosterResearch

  68. Published

    AAV-delivered polycistronic microRNA-clusters for knockdown of VEGF in vivo. / Pihlmann, Maria; Askou, Anne Louise; Aagaard, Lars; Bruun, Gitte Hoffmann; Svalgaard, Jesper Dyrendom; Holm-Nielsen, Marie Hebsgaard; Dagnaes-Hansen, Frederik; Bek, Toke; Mikkelsen, Jacob Giehm; Jensen, Thomas G.; Corydon, Thomas Juhl.

    In: The Journal of Gene Medicine, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  69. Published

    Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin. / Staunstrup, Nicklas Heine; Madsen, Johannes Kjær; Primo, Maria Nascimento; Li, Juan; Liu, Ying; Kragh, Peter M; Li, Rong; Schmidt, Mette; Purup, Stig; Dagnæs-Hansen, Frederik; Svensson, Lars; Petersen, Thomas K; Callesen, Henrik; Bolund, Lars; Mikkelsen, Jacob Giehm.

    In: P L o S One, Vol. 7, No. 5, 2012, p. e36658.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  70. Published

    Generation of minipigs with targeted insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT). / Jakobsen, Jannik E.; Johansen, Marianne Gregers; Schmidt, Mette; Dagnæs-Hansen, Frederik; Dam, Karen; Gunnarsson, Anders; Liu, Ying; Kragh, Peter; Li, Rong; Holm, Ida Elisabeth; Callesen, Henrik; Mikkelsen, Jacob Giehm; Nielsen, Anders Lade; Jørgensen, Arne Lund.

    In: Transgenic Research, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  71. Published

    Hypercholesterolemic minipigs created by liver-specific expression of a PCSK9 gain-of-function mutant. / Bentzon, Jacob Fog; Sørensen, Charlotte Brandt; Al-Mashhadi, Rozh Husain; Kragh, Peter M; Nielsen, Lars Bo; Li, Juan; Lin, Lin; Liu, Ying; Moldt, Brian; Schmidt, Mette; Thim, Troels; Vajta, Gabor; Purup, Stig; Bolund, Lars; Callesen, Henrik; Mikkelsen, Jacob Giehm; Falk, Erling.

    In: Transgenic Research, Vol. 21, No. 4, 2012, p. 910-911.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  72. Published

    Lentiviral vectors for cutaneous RNA managing. / Nascimento Lopes Primo, Maria; Bak, Rasmus O; Mikkelsen, Jacob Giehm.

    In: Experimental Dermatology Online, Vol. 21, No. 3, 2012, p. 162-70.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  73. Published

    Reduced choroidal neovascularization by AAV-anti-VEGF shRNA delivery. / Askou, Anne Louise; Pihlmann, Maria; Pournaras, Jean-Antoine; Arsenijevic, Yvan; Costic, Corinne ; Bek, Toke; Dagnæs-Hansen, Frederik; Mikkelsen, Jacob Giehm; Jensen, Thomas G.; Corydon, Thomas Juhl.

    2012.

    Research output: Contribution to conferencePosterResearch

  74. Published

    Reduction of choroidal neovascularization in mice by adeno-associated virus-delivered anti-vascular endothelial growth factor short hairpin RNA. / Askou, Anne Louise; Pournaras, Jean-Antoine C; Pihlmann, Maria; Svalgaard, Jesper D; Arsenijevic, Yvan; Kostic, Corinne; Bek, Toke; Dagnaes-Hansen, Frederik; Mikkelsen, Jacob Giehm; Jensen, Thomas G.; Corydon, Thomas Juhl.

    In: Journal of Gene Medicine (Online), Vol. 14, No. 11, 2012, p. 632-41.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  75. Published

    Regulation of pro-inflammatory cytokines TNFα and IL24 by microRNA-203 in primary keratinocytes. / Nascimento Primo, Maria; Bak, Rasmus O; Schibler, Beatrice; Mikkelsen, Jacob Giehm.

    In: Cytokine, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  76. Published

    The Impact of cHS4 Insulators on DNA Transposon Vector Mobilization and Silencing in Retinal Pigment Epithelium Cells. / Sharma, Nynne; Hollensen, Anne Kruse; Bak, Rasmus Otkjær; Staunstrup, Nicklas Heine; Schrøder, Lisbeth Dahl; Mikkelsen, Jacob Giehm.

    In: P L o S One, Vol. 7, No. 10, 2012, p. e48421.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  77. Published

    U20 is responsible for human herpesvirus 6B inhibition of TNF receptor-dependent signaling and apoptosis. / Kofod-Olsen, Emil; Ross-Hansen, Katrine; Schleimann, Mariane Høgsbjerg; Jensen, Dea Kejlberg; Møller, Janni Michelle; Bundgaard, Bettina; Mikkelsen, Jacob Giehm; Höllsberg, Per.

    In: Journal of Virology, Vol. 86, 2012, p. 11483-92.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  78. 2011
  79. Published

    Efficient Sleeping Beauty transposition from DNA minicircles. / Cai, Yujia; Sharma, Nynne; Jakobsen, Martin Roelsgaard; Schrøder, Lisbeth Dahl; Bak, Rasmus Otkjær; Mikkelsen, Jacob Giehm.

    2011. Poster session presented at The annual congress of the European Society for Gene and Cell Therapy, Brighton, United Kingdom.

    Research output: Contribution to conferencePosterResearch

  80. Published

    Suppression of miRNA activity by vector-encoded inhibitors. / Bak, Rasmus Otkjær; Primo, Maria Do Nascimento Lopes; Hollensen, Anne Kruse; Mikkelsen, Jacob Giehm.

    2011. Poster session presented at The annual congress of the European Society for Gene and Cell Therapy, Brighton, United Kingdom.

    Research output: Contribution to conferencePosterResearch

  81. Published

    Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells. / Moldt, Brian; Miskey, Csaba; Staunstrup, Nicklas Heine; Gogol-Döring, Andreas; Bak, Rasmus Otkjær; Sharma, Nynne; Mátés, Lajos; Izsvák, Zsuzsanna; Chen, Wei; Ivics, Zoltán; Mikkelsen, Jacob Giehm.

    In: Molecular Therapy, Vol. 19, No. 8, 08.2011.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  82. Published

    Mobilization of DNA transposable elements from lentiviral vectors. / Bak, Rasmus Otkjær; Mikkelsen, Jacob Giehm.

    In: Mobile Genetic Elements, Vol. 1, No. 2, 07.2011, p. 139-144.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  83. Published

    A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues. / Staunstrup, Nicklas H; Sharma, Nynne; Bak, Rasmus O; Svensson, Lars; Petersen, Thomas K; Aarenstrup, Lene; Kristiansen, Karsten; Bolund, Lars; Mikkelsen, Jacob Giehm.

    In: B M C Biotechnology, Vol. 11, No. 1, 07.04.2011, p. 33.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  84. Published

    Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin. / Bak, Rasmus O; Stenderup, Karin; Rosada, Cecilia; Petersen, Line B; Moldt, Brian; Dagnæs-Hansen, Frederik; Jakobsen, Maria; Kamp, Soren; Jensen, Thomas G; Dam, Tomas N; Mikkelsen, Jacob Giehm.

    In: B M C Dermatology, Vol. 11, No. 1, 27.02.2011, p. 5.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  85. Published

    Establishment of a pig fibroblast-derived cell line for locus-directed transgene expression in cell cultures and blastocysts. / Jakobsen, Jannik E; Li, Juan; Moldt, Brian; Kragh, Peter M; Callesen, Henrik; Hertz, Jens Michael; Bolund, Lars; Jørgensen, Arne Lund; Mikkelsen, Jacob Giehm; Nielsen, Anders Lade.

    In: Molecular Biology Reports, Vol. 38, No. 1, 2011, p. 151-61.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  86. Published

    Integrase-defective lentiviral vectors--a stage for nonviral integration machineries. / Staunstrup, Nicklas H; Mikkelsen, Jacob Giehm.

    In: Current Gene Therapy, Vol. 11, No. 5, 2011, p. 350-62.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  87. Published

    Pig transgenesis by Sleeping Beauty DNA transposition. / Jakobsen, Jannik E.; Li, Juan; Kragh, Peter M; Moldt, Brian; Lin, Lin; Liu, Ying; Schmidt, Mette; Winther, Kjeld Dahl; Schyth, Brian Dall; Holm, Ida Elisabeth; Vajta, Gabor; Bolund, Lars; Callesen, Henrik; Jørgensen, Arne Lund; Nielsen, Anders Lade; Mikkelsen, Jacob Giehm.

    In: Transgenic Research, Vol. 20, No. 3, 2011, p. 533-545.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  88. 2010
  89. Published

    microRNA-clusters for AAV-based treatment of age-related macular degeneration (AMD). / Pihlmann, Maria; Aagaard, Lars; Hindkjær, Tina; Mikkelsen, Jacob Giehm; Bek, Toke; Jensen, Thomas G.; Corydon, Thomas Juhl.

    In: European Society of Gene & Cell Therapy, abstract book, 22.10.2010, p. 411-411.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  90. Published

    Cytokine regulation in psoriasis by endogenous and viral vector-delivered small non-coding RNAs. / Bak, Rasmus Otkjær; Jakobsen, Maria; Stenderup, Karin; Rosada, Cecilia; Barrett Petersen, Line; Moldt, Brian; Dagnæs-Hansen, Frederik; Kamp, Søren; Jensen, Thomas G.; Dam, Tomas Norman; Mikkelsen, Jacob Giehm.

    2010. Abstract from Novo Scholarship Symposium, Copenhagen, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  91. Published

    Elimination of the plasmid bacterial backbone in site-directed transgenesis. / Jakobsen, Jannik E.; Mikkelsen, Jacob Giehm; Nielsen, Anders Lade.

    In: BioTechniques, Vol. 48, No. 4, 2010.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  92. Published

    Regulation of cytokine expression by lentivirus-encoded RNA antagomirs. / Bak, Rasmus Otkjær; Barrett Petersen, Line; Moldt, Brian; Stenderup, Karin; Rosada, Cecilia; Aagaard, Lars; Dam, Tomas Norman; Mikkelsen, Jacob Giehm.

    2010. Poster session presented at American Society of Gene Therapy 13th Annual Meeting, Washington, United States.

    Research output: Contribution to conferencePosterResearch

  93. Published

    Regulation of cytokines by small RNAs during skin inflammation. / Bak, Rasmus Otkjær; Mikkelsen, Jacob Giehm.

    In: Journal of Biomedical Science, Vol. 17, No. 53, 2010.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  94. Published

    Targeting of human interleukin-12B by small hairpin RNAa in xenografted psoriatic skin. / Stenderup, Karin; Bak, Rasmus Otkjær; Rosada, Cecilia; Petersen, Line Berrett; Moldt, Brian; Dagnæs-Hansen, Frederik; Jakobsen, Maria; Kamp, Søren; Jensen, Thomas G.; Dam, Tomas Norman; Mikkelsen, Jacob Giehm.

    In: Journal of Investigative Dermatology, No. 130, 2010.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  95. 2009
  96. Published

    Hybrid Lentivirus-transposon Vectors With a Random Integration Profile in Human Cells. / Staunstrup, Nicklas H; Moldt, Brian; Mátés, Lajos; Villesen, Palle; Jakobsen, Maria; Ivics, Zoltán; Izsvák, Zsuzsanna; Mikkelsen, Jacob Giehm.

    In: Molecular Therapy, Vol. 17, No. 7, 01.07.2009, p. 1205-14.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  97. Published

    Amelioration of Psoriasis by Anti-TNF-alpha RNAi in the Xenograft Transplantation Model. / Jakobsen, Maria; Stenderup, Karin; Rosada, Cecilia; Moldt, Brian; Kamp, Søren; Dam, Tomas N; Jensen, Thomas G; Mikkelsen, Jacob Giehm.

    In: Molecular Therapy, 2009.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  98. Published
  99. Published

    Development of gene therapy for age-related macula degeneration (AMD). / Svalgaard, Jesper; Mikkelsen, Jacob Giehm; Bek, Toke; Jensen, Thomas G.; Corydon, Thomas Juhl.

    In: Human Gene Therapy, No. 11, 2009, p. 1448.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  100. Published

    Efficient SB100X-directed transposition from non-integrating lentiviral vectors in primary human cells. / Moldt, Brian; Staunstrup, Nicklas Heine; Bak, Rasmus Otkjær; Sharma, Nynne; Mates, Lajos; Izsvak, Zsuzsanna; Ivics, Zoltan; Mikkelsen, Jacob Giehm.

    2009. Abstract from European Society of Gene and Cellular Therapy Annual Meeting, Hannover, Germany.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  101. Published

    Shielding of Sleeping Beauty DNA Transposon-delivered Transgene Cassettes by Heterologous Insulators in Early Embryonal Cells. / Dalsgaard, Trine; Moldt, Brian; Sharma, Nynne; Wolf, Gernot; Schmitz, Alexander; Pedersen, Finn S; Mikkelsen, Jacob G.

    In: Molecular Therapy, Vol. 17, No. 1, 2009, p. 121-130.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  102. 2008
  103. Published

    Alleviation of psoriasis upon genetic knockdown of human tumour necrosis factor-alfa by lentivirus-encoded short hairpin RNA in a xenograft transplantation model. / Stenderup, Karin; Jakobsen, Maria Vad; Rosada, Cecilia; Moldt, Brian; Kamp, Søren; Dam, Tomas Norman; Jensen, Thomas G.; Mikkelsen, Jacob Giehm.

    2008. Abstract from Psoriasis: From Gene to Clinic, London, United Kingdom.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  104. Published

    Delivering the Goods - Therapeutic RNAi for Human Genetic Disease. / Mikkelsen, Jacob Giehm; Carlsen, Inge Gram; Jakobsen, Maria; Corydon, Thomas Juhl.

    Research Progress in Antisense Elements (Genetics). ed. / Jessica C. Taylor; Amelia J. Williams. Nova Science Publishers, 2008.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearch

  105. Published

    Genomic insertion of lentiviral DNA circles directed by the yeast Flp recombinase. / Moldt, Brian; Staunstrup, Nicklas Heine; Jakobsen, Maria; Yanez-Munoz, Rafael J; Mikkelsen, Jacob Giehm.

    In: B M C Biotechnology, Vol. 8, 2008.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  106. Published

    High-Efficiency Sleeping Beauty Transposition from Lentiviral DNA Substrates in Primary Human Cells. / Moldt, Brian; Staunstrup, Nicklas Heine; Jakobsen, Maria; Mates, Lajos; Ivics, Zoltan; Izsvak, Zsuzsanna; Mikkelsen, Jacob Giehm.

    2008. Poster session presented at American Society of Gene Therapy 11th Annual Meeting, Boston, United States.

    Research output: Contribution to conferencePosterResearch

  107. Published

    Human herpesvirus 6B U19 protein is a PML-regulated transcriptional activator that localizes to nuclear foci in a PML-independent manner. / Kofod-Olsen, Emil; Ross-Hansen, Katrine; Mikkelsen, Jacob Giehm; Höllsberg, Per.

    In: Journal of General Virology, Vol. 89, 2008, p. 106-16.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  108. Published

    Is TNF-a-targeted short hairpin RNA (shRNA) a novel potential therapeutic tool in psoriasis treatment? / Stenderup, Karin; Jakobsen, Maria; Rosada, Cecilia; Moldt, Brian; Kamp, Søren; Dam, Tomas Norman; Jensen, Thomas G.; Mikkelsen, Jacob Giehm.

    In: Journal of Investigative Dermatology, Vol. 128, No. suppl 1, 2008, p. 113 no 674.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  109. Published

    Partial Correction of Psoriasis upon Genetic Knock-Down of Human TNF-α by Lentivirus-Encoded shRNAs in a Xenograft Mouse Model. / Jakobsen, Maria; Stenderup, Karin; Rosada, Cecilia; Moldt, Brian; Kamp, Søren; Dam, Tomas Norman; Jensen, Thomas G.; Mikkelsen, Jacob Giehm.

    2008. Abstract from American Society of Gene Therapy, Boston, Massachusetts, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  110. Published

    Regulated gene insertion by steroid-induced PhiC31 integrase. / Sharma, Nynne; Moldt, Brian; Dalsgaard, Trine; Jensen, Thomas G.; Mikkelsen, Jacob Giehm.

    In: Nucleic Acids Research, 2008, p. e67.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  111. 2007
  112. Published

    Cis-acting gene regulatory activities in the terminal regions of sleeping beauty DNA transposon-based vectors. / Moldt, Brian; Yant, Stephen R; Andersen, Peter Refsing; Kay, Mark A; Mikkelsen, Jacob Giehm.

    In: Human Gene Therapy, Vol. 18, No. 12, 01.12.2007, p. 1193-204.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  113. Published

    Cis-acting gene regulatory activities in the terminal regions of sleeping beauty DNA transposon-based vectors. / Moldt, Brian; Yant, Stephen R.; Andersen, Peter Refsing; Kay, Mark A.; Mikkelsen, Jacob Giehm.

    In: Human Gene Therapy, Vol. 18, No. 12, 2007, p. 1193-204.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  114. Published

    Site-Specific Genomic Integration of Lentiviral DNA Circles. / Moldt, Brian; Staunstrup, Nicklas Heine; Jakobsen, Maria; Yáñez-Muñoz, Rafael J.; Mikkelsen, Jacob Giehm.

    2007. Poster session presented at American Society of Gene Therapy 10th Annual Meeting, Seattle, United States.

    Research output: Contribution to conferencePosterResearch

  115. 2006
  116. Published

    RNA-interferens - vejen til individualiseret genetisk medicin. / Corydon, Thomas Juhl; Mikkelsen, Jacob Giehm.

    In: Ugeskrift for Laeger, Vol. 50, No. 168, 2006, p. 4401.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

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