Jacob Giehm Mikkelsen

  1. 2022
  2. Published

    Delivering genes with human immunodeficiency virus-derived vehicles : still state-of-the-art after 25 years. / Wolff, Jonas Holst; Mikkelsen, Jacob Giehm.

    In: Journal of Biomedical Science, Vol. 29, 79, 10.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  3. Published

    A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer. / Ipsen, Malene Blond; Sørensen, Ea Marie Givskov; Thomsen, Emil Aagaard et al.

    In: Oncogene, Vol. 41, No. 37, 09.2022, p. 4271-4281.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. Published

    A truncated reverse transcriptase enhances prime editing by split AAV vectors. / Gao, Zongliang; Ravendran, Sujan; Mikkelsen, Nanna S. et al.

    In: Molecular Therapy, Vol. 30, No. 9, 09.2022, p. 2942-2951.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    CRISPR-Cas9-directed gene tagging using a single integrase-defective lentiviral vector carrying a transposase-based Cas9 off switch. / Thomsen, Emil Aagaard; Skipper, Kristian Alsbjerg; Andersen, Sofie et al.

    In: Molecular Therapy - Nucleic Acids, Vol. 29, 09.2022, p. 563-576.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. Published

    Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic. / Duncan, Christopher J A; Skouboe, Morten K; Howarth, Sophie et al.

    In: The Journal of Experimental Medicine, Vol. 219, No. 6, e20212427, 06.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. Published

    Regulation of Ncbe in the Choroid Plexus of Mice after Hemorrhage-Induced Hydrocephalus. / Johnsen, Laura; Friis, Kathrine A.; Ryø, Laura B. et al.

    In: The FASEB Journal, Vol. 36, No. S1, 05.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    Simple Autofluorescence-Restrictive Sorting of eGFP+ RPE Cells Allows Reliable Assessment of Targeted Retinal Gene Therapy. / Kalaee, Sidsel Alsing; Lindholm, Anna Bøgh; Haldrup, Jakob et al.

    In: Frontiers in Drug Delivery, Vol. 2, 898568, 05.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    Single-Cell Monitoring of Activated Innate Immune Signaling by a d2eGFP-Based Reporter Mimicking Time-Restricted Activation of IFNB1 Expression. / Thomsen, Emil Aagaard; Andersen, Sofie; Marqvorsen, Mikkel Haarslev Schröder et al.

    In: Frontiers in cellular and infection microbiology, Vol. 11, 784762, 01.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. 2021
  11. Published

    Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient. / Brinck Andersen, Nanna Sophie; Jørgensen, Sofie Eg; Skipper, Kristian Alsbjerg et al.

    In: Autophagy, Vol. 17, No. 9, 09.2021, p. 2449-2464.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    PegIT - A web-based design tool for prime editing. / Anderson, Mads Valdemar; Haldrup, Jakob; Thomsen, Emil Aagaard et al.

    In: Nucleic Acids Research, Vol. 49, No. W1, 07.2021, p. W505-W509.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Retroviral Replication. / Pedersen, Finn Skou; Mikkelsen, Jacob Giehm.

    Encyclopedia of Life Sciences: Virology. Vol. 2 Chichester : John Wiley & Sons Ltd., 2021. p. 1-12.

    Research output: Contribution to book/anthology/report/proceedingBook chapterCommunication

  14. Published

    Targeted Knockout of the Vegfa Gene in the Retina by Subretinal Injection of RNP Complexes Containing Cas9 Protein and Modified sgRNAs. / Holmgaard, Andreas Braae; Askou, Anne Louise; Jensen, Emilie Grarup et al.

    In: Molecular Therapy, Vol. 29, No. 1, 01.2021, p. 191-207.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. 2020
  16. Published

    Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans. / Hait, Alon Schneider; Olagnier, David; Sancho-Shimizu, Vanessa et al.

    In: Science Immunology, Vol. 5, No. 54, eabc2691, 12.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization. / Dalskov, Louise; Narita, Ryo; Andersen, Line L. et al.

    In: Nucleic Acids Research, Vol. 48, No. 20, 11.2020, p. 11421-11433.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    MicroRNA-106b Regulates Expression of the Tumour Suppressors p21 and TXNIP and Promotes Tumour Cell Proliferation in Mycosis Fungoides. / Lindahl, Lise M; Gluud, Maria; Emmanuel, Thomas et al.

    In: Acta Dermato-Venereologica, Vol. 100, adv00270, 09.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. Published

    Identification of BLNK and BTK as mediators of rituximab-induced programmed cell death by CRISPR screens in GCB-subtype diffuse large B-cell lymphoma. / Thomsen, Emil Aagaard; Rovsing, Anne Bruun; Anderson, Mads Valdemar et al.

    In: Molecular Oncology, Vol. 14, No. 9, 2020, p. 1978-1997.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. 2019
  21. Published

    Sustained transgene expression from sleeping beauty DNA transposons containing a core fragment of the HNRPA2B1-CBX3 ubiquitous chromatin opening element (UCOE). / Skipper, Kristian Alsbjerg; Hollensen, Anne Kruse; Antoniou, Michael N et al.

    In: BMC Biotechnology, Vol. 19, No. 1, 75, 09.11.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy. / Askou, Anne Louise; Alsing, Sidsel; Benckendorff, Josephine N.E. et al.

    In: Molecular Therapy - Nucleic Acids, Vol. 16, 07.06.2019, p. 38-50.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    MicroRNA-155 controls vincristine sensitivity and predicts superior clinical outcome in diffuse large B-cell lymphoma. / Due, Hanne; Schönherz, Anna Amanda; Ryø, Laura et al.

    In: Blood Advances, Vol. 3, No. 7, 09.04.2019, p. 1185-1196.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    CRISPR-Based Lentiviral Knockout Libraries for Functional Genomic Screening and Identification of Phenotype-Related Genes. / Thomsen, Emil Aagaard; Mikkelsen, Jacob Giehm.

    In: Methods in Molecular Biology, 2019, p. 343-357.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleCommunication

  25. Published

    Dominant negative SERPING1 variants cause intracellular retention of C1-inhibitor in hereditary angioedema. / Haslund, Didde; Ryø, Laura Barrett; Majidi, Sara Seidelin et al.

    In: Journal of Clinical Investigation, Vol. 129, No. 1, CI98869, 2019, p. 388-405.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Published

    Production and Validation of Lentiviral Vectors for CRISPR/Cas9 Delivery. / Ryø, Laura Barrett; Thomsen, Emil Aagaard; Mikkelsen, Jacob Giehm.

    In: Methods in Molecular Biology, 2019, p. 93-109.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleCommunication

  27. 2018
  28. Published

    Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs. / Hollensen, Anne Kruse; Andersen, Sofie; Hjorth, Karina et al.

    In: Molecular Therapy - Nucleic Acids, Vol. 13, 07.12.2018, p. 365-375.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published

    Viral delivery of genome-modifying proteins for cellular reprogramming. / Mikkelsen, Jacob Giehm.

    In: Current Opinion in Genetics & Development, Vol. 52, 10.2018, p. 92-99.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  30. Published

    Retroviruses in Human Gene Therapy. / Pedersen, Finn Skou; Mikkelsen, Jacob Giehm.

    In: Encyclopedia of Life Sciences, 17.09.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleCommunication

  31. Published

    Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein. / Dalsgaard, Trine; Kaadt, Claudia Regina Cecchi; Askou, Anne Louise et al.

    In: Molecular Therapy - Nucleic Acids, Vol. 12, 07.09.2018, p. 672-683.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. Published

    Time-Restricted PiggyBac DNA Transposition by Transposase Protein Delivery Using Lentivirus-Derived Nanoparticles. / Skipper, Kristian Alsbjerg; Nielsen, Mathias Gaarde; Andersen, Sofie et al.

    In: Molecular Therapy - Nucleic Acids, Vol. 11, 01.06.2018, p. 253-262.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. Published

    Defective RNA sensing by RIG-I in severe influenza virus infection. / Jørgensen, Sofie Eg; Christiansen, Mette; Ryø, Laura Barrett et al.

    In: Clinical and Experimental Immunology, Vol. 192, No. 3, 06.2018, p. 366-376.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. 2017
  35. Published

    In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells. / Holmgaard, Andreas; Askou, Anne Louise; Benckendorff, Josephine Natalia Esther et al.

    In: Molecular Therapy - Nucleic Acids, Vol. 9, 15.12.2017, p. 89-99.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. Published

    Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections. / Ogunjimi, Benson; Zhang, Shen-Ying; Sørensen, Katrine Biehl et al.

    In: Journal of Clinical Investigation, 01.09.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  37. Published

    Improved microRNA suppression by WPRE-linked Tough Decoy microRNA sponges. / Hollensen, Anne Kruse; Thomsen, Rune; Bak, Rasmus O et al.

    In: RNA, Vol. 23, No. 8, 08.2017, p. 1247-1258.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. Published

    Suppression of Choroidal Neovascularization in Mice by Subretinal Delivery of Multigenic Lentiviral Vectors Encoding Anti-Angiogenic MicroRNAs. / Askou, Anne Louise; Benckendorff, Josephine Natalia Esther; Holmgaard, Andreas et al.

    In: Human Gene Therapy. Methods, Vol. 28, No. 4, 08.2017, p. 222-233.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  39. Published

    Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1. / Staunstrup, Nicklas Heine; Stenderup, Karin; Mortensen, Sidsel et al.

    In: Disease Models & Mechanisms, Vol. 10, 01.07.2017, p. 869-880.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. / Jønsson, K L; Laustsen, A; Krapp, C et al.

    In: Nature Communications, Vol. 8, 14391, 10.02.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  41. 2016
  42. Published

    Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection. / Thomsen, Martin K; Nandakumar, Ramya; Stadler, Daniela et al.

    In: Hepatology, Vol. 64, No. 3, 16.06.2016, p. 746-759.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. Published

    Anti-Apoptotic Effects of Lentiviral Vector Transduction Promote Increased Rituximab Tolerance in Cancerous B-Cells. / Ranjbar, Ben; Krogh, Louise; Laursen, Maria Bach et al.

    In: PLOS ONE, Vol. 11, No. 4, 05.04.2016, p. e0153069.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. Published

    Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses. / Holm, Christian K; Rahbek, Stine H; Gad, Hans Henrik et al.

    In: Nature Communications, Vol. 7, 10680, 19.02.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  45. Published

    High miR-34a expression improves response to doxorubicin in diffuse large B-cell lymphoma. / Marques, Sara Correia; Ranjbar, Ben; Laursen, Maria Bach et al.

    In: Experimental Hematology, 17.02.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. Published

    Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors. / Cai, Yujia; Laustsen, Anders; Zhou, Yan et al.

    In: eLife, Vol. 5, 2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  47. 2015
  48. Published

    Efficient in vivo gene transfer to xenotransplanted human skin by lentivirus-mediated, but not by AAV-directed, gene delivery. / Jakobsen, Maria Vad; Askou, Anne Louise; Dokkedahl, Karin Stenderup et al.

    2015. Poster session presented at Annual Congress The European Society of Gene and Cell Therapy (ESGCT), Helsinki, Finland.

    Research output: Contribution to conferencePosterResearchpeer-review

  49. Published

    Robust Lentiviral Gene Delivery But Limited Transduction Capacity of Commonly Used Adeno-Associated Viral Serotypes in Xenotransplanted Human Skin. / Jakobsen, Maria; Askou, Anne Louise; Stenderup, Karin et al.

    In: Human Gene Therapy. Methods, Vol. 26, No. 4, 08.2015, p. 123-33.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  50. Published
  51. Published

    Overexpression of MicroRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus. / Rasmussen, Tue Kruse; Andersen, Thomas; Bak, Rasmus Otkjær et al.

    In: Arthritis research & therapy, Vol. 17, No. 1, 154, 09.06.2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  52. Published

    Functional IRF3 deficiency in a patient with herpes simplex encephalitis. / Andersen, Line Lykke; Mørk, Nanna; Reinert, Line S et al.

    In: Journal of Experimental Medicine, Vol. 212, No. 9, 2015, p. 1371-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  53. Published

    Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors. / Askou, Anne Louise; Aagaard, Lars; Kostic, Corinne et al.

    In: Molecular therapy. Methods & clinical development, Vol. 2, 2015, p. 14064.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  54. 2014
  55. Published

    Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases. / Cai, Yujia; Bak, Rasmus; Mikkelsen, Jacob Giehm.

    In: eLife, Vol. 3, 24.04.2014, p. e01911.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  56. Published

    Induction of Atherosclerosis in Mice and Hamsters Without Germline Genetic Engineering. / Bjørklund, Martin Mæng; Hollensen, Anne K; Hagensen, Mette K et al.

    In: Circulation Research, 27.03.2014.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  57. Published

    Integration-deficient lentiviral vectors as gene delivery vehicles for treatment of AMD. / Askou, Anne Louise; Hebsgaard Holm-Nielsen, Maria; Jensen, Thomas G. et al.

    2014. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Versailles, France.

    Research output: Contribution to conferencePosterResearchpeer-review

  58. 2013
  59. Published

    miRNA sponges: soaking up miRNAs for regulation of gene expression. / Bak, Rasmus; Mikkelsen, Jacob Giehm.

    In: Wiley Interdisciplinary Reviews: RNA, 23.12.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  60. Published

    DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors. / Cai, Yujia; Bak, Rasmus O.; Krogh, Louise Bechmann et al.

    In: Nucleic Acids Research, 21.11.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  61. Published

    Integrase-defective lentiviral vectors-a stage for nonviral integration machineries. / Staunstrup, Nicklas Heine; Mikkelsen, Jacob Giehm.

    In: Current Gene Therapy, 05.11.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  62. Published

    DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors. / Cai, Yujia; Bak, Rasmus O.; Krogh, Louise B. et al.

    2013. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Madrid, Spain.

    Research output: Contribution to conferencePosterResearch

  63. Published

    MicroRNA inhibition by dual-targeting and clustered Tough Decoy inhibitors. / Hollensen, Anne Kruse; Bak, Rasmus O.; Haslund, Didde et al.

    2013. Abstract from Annual Congress of the European Society of Gene and Cell Therapy, Madrid, Spain.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  64. Published

    Multigenic lentiviral vectors for anti-angiogenic treatment of age-related macular degeneration (AMD). / Askou, Anne Louise; Aagaard, Lars; Kostic, Corinne et al.

    2013. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Madrid, Spain.

    Research output: Contribution to conferencePosterResearch

  65. Published

    Targeted genome editing by lentiviral protein transduction of zinc‐finger and TAL‐effector nucleases. / Cai, Yujia; Bak, Rasmus O.; Mikkelsen, Jacob Giehm.

    2013. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Madrid, Spain.

    Research output: Contribution to conferencePosterResearch

  66. Published

    IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. / Jakobsen, Martin Roelsgaard; Bak, Rasmus O; Andersen, Annika et al.

    In: Proceedings of the National Academy of Sciences of the United States of America, 23.10.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  67. Published
  68. Published

    Managing MicroRNAs with Vector-Encoded Decoy-Type Inhibitors. / Bak, Rasmus Otkjær; Hollensen, Anne Kruse; Mikkelsen, Jacob Giehm.

    In: Molecular Therapy, Vol. 21, No. 8, 08.2013, p. 1478-85.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  69. Published

    A lentiviral vector-based genetic sensor system for comparative analysis of permeability and activity of vitamin D3 analogues in xenotransplanted human skin. / Staunstrup, Nicklas Heine; Bak, Rasmus Otkjær; Cai, Yujia et al.

    In: Experimental Dermatology, Vol. 22, No. 3, 22.03.2013, p. 178-83.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  70. Published

    Efficient sleeping beauty DNA transposition from DNA minicircles. / Sharma, Nynne; Cai, Yujia; Bak, Rasmus O et al.

    In: Molecular Therapy - Nucleic Acids, Vol. 2, 2013, p. e74.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  71. Published

    Epigenetic marking and repression of porcine endogenous retroviruses. / Wolf, Gernot; Mikkelsen, Jacob Giehm; Nielsen, Anders Lade et al.

    In: Journal of General Virology, Vol. 94, No. 5, 2013, p. 960- 970.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  72. Published

    Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant. / Al-Mashhadi, Rozh H; Sørensen, Charlotte B; Kragh, Peter M et al.

    In: Science Translational Medicine, Vol. 5, No. 166, 2013, p. 166ra1.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  73. Published

    Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT). / Jakobsen, Jannik Ejnar; Johansen, Marianne G; Schmidt, Mette et al.

    In: Transgenic Research, Vol. 22, 2013, p. 709-723.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  74. Published

    Inhibition of p53-dependent, but not p53-independent, cell death by U19 protein from human herpesvirus 6B. / Kofod-Olsen, Emil; Møller, Janni Michelle; Schleimann, Mariane Høgsbjerg et al.

    In: P L o S One, Vol. 8, No. e59223, 2013, p. 1-11.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  75. Published

    Potent microRNA suppression by RNA Pol II-transcribed 'Tough Decoy' inhibitors. / Bak, Rasmus Otkjær; Hollensen, Anne Kruse; Primo, Maria Nascimento et al.

    In: RNA, Vol. 19, No. 2, 2013, p. 280-293.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  76. Published

    Suppression of microRNAs by dual-targeting and clustered Tough Decoy inhibitors. / Hollensen, Anne Kruse; Bak, Rasmus Otkjær; Haslund, Didde et al.

    In: RNA Biology, Vol. 10, No. 3, 2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  77. 2012
  78. Published

    Potent microRNA suppression by RNA Pol II-transcribed Tough Decoy inhibitors. / Bak, Rasmus Otkjær; Hollensen, Anne Kruse; Nascimento Primo, Maria et al.

    2012. Poster session presented at Annual Congress of the European Society of Gene and Cell Therapy, Versailles, France.

    Research output: Contribution to conferencePosterResearch

  79. Published

    Variable Potency and Transfer Efficiency of Lentivirus-Encoded miRNA Inhibitors. / Bak, Rasmus Otkjær; Hollensen, Anne Kruse; Primo, Maria Do Nascimento Lopes et al.

    2012. Poster session presented at Keystone Symposia, Santa Fe, New Mexico, United States.

    Research output: Contribution to conferencePosterResearch

  80. Published

    AAV-delivered polycistronic microRNA-clusters for knockdown of VEGF in vivo. / Pihlmann, Maria; Askou, Anne Louise; Aagaard, Lars et al.

    In: The Journal of Gene Medicine, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  81. Published

    Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin. / Staunstrup, Nicklas Heine; Madsen, Johannes Kjær; Primo, Maria Nascimento et al.

    In: P L o S One, Vol. 7, No. 5, 2012, p. e36658.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  82. Published

    Hypercholesterolemic minipigs created by liver-specific expression of a PCSK9 gain-of-function mutant. / Bentzon, Jacob Fog; Sørensen, Charlotte Brandt; Al-Mashhadi, Rozh Husain et al.

    In: Transgenic Research, Vol. 21, No. 4, 2012, p. 910-911.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  83. Published

    Lentiviral vectors for cutaneous RNA managing. / Nascimento Lopes Primo, Maria; Bak, Rasmus O; Mikkelsen, Jacob Giehm.

    In: Experimental Dermatology Online, Vol. 21, No. 3, 2012, p. 162-70.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  84. Published

    Reduced choroidal neovascularization by AAV-anti-VEGF shRNA delivery. / Askou, Anne Louise; Pihlmann, Maria; Pournaras, Jean-Antoine et al.

    2012.

    Research output: Contribution to conferencePosterResearch

  85. Published

    Reduction of choroidal neovascularization in mice by adeno-associated virus-delivered anti-vascular endothelial growth factor short hairpin RNA. / Askou, Anne Louise; Pournaras, Jean-Antoine C; Pihlmann, Maria et al.

    In: Journal of Gene Medicine (Online), Vol. 14, No. 11, 2012, p. 632-41.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  86. Published

    Regulation of pro-inflammatory cytokines TNFα and IL24 by microRNA-203 in primary keratinocytes. / Nascimento Primo, Maria; Bak, Rasmus O; Schibler, Beatrice et al.

    In: Cytokine, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  87. Published

    The Impact of cHS4 Insulators on DNA Transposon Vector Mobilization and Silencing in Retinal Pigment Epithelium Cells. / Sharma, Nynne; Hollensen, Anne Kruse; Bak, Rasmus Otkjær et al.

    In: PLOS ONE, Vol. 7, No. 10, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  88. Published

    U20 is responsible for human herpesvirus 6B inhibition of TNF receptor-dependent signaling and apoptosis. / Kofod-Olsen, Emil; Ross-Hansen, Katrine; Schleimann, Mariane Høgsbjerg et al.

    In: Journal of Virology, Vol. 86, 2012, p. 11483-92.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  89. 2011
  90. Published

    Efficient Sleeping Beauty transposition from DNA minicircles. / Cai, Yujia; Sharma, Nynne; Jakobsen, Martin Roelsgaard et al.

    2011. Poster session presented at The annual congress of the European Society for Gene and Cell Therapy, Brighton, United Kingdom.

    Research output: Contribution to conferencePosterResearch

  91. Published

    Suppression of miRNA activity by vector-encoded inhibitors. / Bak, Rasmus Otkjær; Primo, Maria Do Nascimento Lopes; Hollensen, Anne Kruse et al.

    2011. Poster session presented at The annual congress of the European Society for Gene and Cell Therapy, Brighton, United Kingdom.

    Research output: Contribution to conferencePosterResearch

  92. Published

    Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells. / Moldt, Brian; Miskey, Csaba; Staunstrup, Nicklas Heine et al.

    In: Molecular Therapy, Vol. 19, No. 8, 08.2011.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  93. Published

    Mobilization of DNA transposable elements from lentiviral vectors. / Bak, Rasmus Otkjær; Mikkelsen, Jacob Giehm.

    In: Mobile Genetic Elements, Vol. 1, No. 2, 07.2011, p. 139-144.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  94. Published

    A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues. / Staunstrup, Nicklas H; Sharma, Nynne; Bak, Rasmus O et al.

    In: B M C Biotechnology, Vol. 11, No. 1, 07.04.2011, p. 33.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  95. Published

    Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin. / Bak, Rasmus O; Stenderup, Karin; Rosada, Cecilia et al.

    In: B M C Dermatology, Vol. 11, No. 1, 27.02.2011, p. 5.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  96. Published

    Establishment of a pig fibroblast-derived cell line for locus-directed transgene expression in cell cultures and blastocysts. / Jakobsen, Jannik E; Li, Juan; Moldt, Brian et al.

    In: Molecular Biology Reports, Vol. 38, No. 1, 2011, p. 151-61.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  97. Published

    Integrase-defective lentiviral vectors--a stage for nonviral integration machineries. / Staunstrup, Nicklas H; Mikkelsen, Jacob Giehm.

    In: Current Gene Therapy, Vol. 11, No. 5, 2011, p. 350-62.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  98. Published

    Pig transgenesis by Sleeping Beauty DNA transposition. / Jakobsen, Jannik E.; Li, Juan; Kragh, Peter M et al.

    In: Transgenic Research, Vol. 20, No. 3, 2011, p. 533-545.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  99. 2010
  100. Published

    microRNA-clusters for AAV-based treatment of age-related macular degeneration (AMD). / Pihlmann, Maria; Aagaard, Lars; Hindkjær, Tina et al.

    In: European Society of Gene & Cell Therapy, abstract book, 22.10.2010, p. 411-411.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  101. Published

    Cytokine regulation in psoriasis by endogenous and viral vector-delivered small non-coding RNAs. / Bak, Rasmus Otkjær; Jakobsen, Maria; Stenderup, Karin et al.

    2010. Abstract from Novo Scholarship Symposium, Copenhagen, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  102. Published

    Elimination of the plasmid bacterial backbone in site-directed transgenesis. / Jakobsen, Jannik E.; Mikkelsen, Jacob Giehm; Nielsen, Anders Lade.

    In: BioTechniques, Vol. 48, No. 4, 2010.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  103. Published

    Regulation of cytokine expression by lentivirus-encoded RNA antagomirs. / Bak, Rasmus Otkjær; Barrett Petersen, Line; Moldt, Brian et al.

    2010. Poster session presented at American Society of Gene Therapy 13th Annual Meeting, Washington, United States.

    Research output: Contribution to conferencePosterResearch

  104. Published

    Regulation of cytokines by small RNAs during skin inflammation. / Bak, Rasmus Otkjær; Mikkelsen, Jacob Giehm.

    In: Journal of Biomedical Science, Vol. 17, No. 53, 2010.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  105. Published

    Targeting of human interleukin-12B by small hairpin RNAa in xenografted psoriatic skin. / Stenderup, Karin; Bak, Rasmus Otkjær; Rosada, Cecilia et al.

    In: Journal of Investigative Dermatology, No. 130, 2010.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  106. 2009
  107. Published

    Hybrid Lentivirus-transposon Vectors With a Random Integration Profile in Human Cells. / Staunstrup, Nicklas H; Moldt, Brian; Mátés, Lajos et al.

    In: Molecular Therapy, Vol. 17, No. 7, 01.07.2009, p. 1205-14.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  108. Published

    Amelioration of Psoriasis by Anti-TNF-alpha RNAi in the Xenograft Transplantation Model. / Jakobsen, Maria; Stenderup, Karin; Rosada, Cecilia et al.

    In: Molecular Therapy, 2009.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  109. Published
  110. Published

    Development of gene therapy for age-related macula degeneration (AMD). / Svalgaard, Jesper; Mikkelsen, Jacob Giehm; Bek, Toke et al.

    In: Human Gene Therapy, No. 11, 2009, p. 1448.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  111. Published

    Efficient SB100X-directed transposition from non-integrating lentiviral vectors in primary human cells. / Moldt, Brian; Staunstrup, Nicklas Heine; Bak, Rasmus Otkjær et al.

    2009. Abstract from European Society of Gene and Cellular Therapy Annual Meeting, Hannover, Germany.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  112. Published

    Shielding of Sleeping Beauty DNA Transposon-delivered Transgene Cassettes by Heterologous Insulators in Early Embryonal Cells. / Dalsgaard, Trine; Moldt, Brian; Sharma, Nynne et al.

    In: Molecular Therapy, Vol. 17, No. 1, 2009, p. 121-130.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  113. 2008
  114. Published

    Alleviation of psoriasis upon genetic knockdown of human tumour necrosis factor-alfa by lentivirus-encoded short hairpin RNA in a xenograft transplantation model. / Stenderup, Karin; Jakobsen, Maria Vad; Rosada, Cecilia et al.

    2008. Abstract from Psoriasis: From Gene to Clinic, London, United Kingdom.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  115. Published

    Delivering the Goods - Therapeutic RNAi for Human Genetic Disease. / Mikkelsen, Jacob Giehm; Carlsen, Inge Gram; Jakobsen, Maria et al.

    Research Progress in Antisense Elements (Genetics). ed. / Jessica C. Taylor; Amelia J. Williams. Nova Science Publishers, 2008.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearch

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