Projects per year
Personal profile
Research
My research focuses on bladder cancer genomics, tumor evolution, and ctDNA-based monitoring of minimal residual disease and treatment response. I specialize in exome, whole-genome, and targeted sequencing of cfDNA and tissue, applied in both prospective trials and retrospective cohort studies. My research has contributed to key discoveries in bladder cancer subtypes, ctDNA detection, mutational signatures, and TCR repertoire profiling.
Profile
Translational cancer researcher specializing in bladder cancer, with expertise in circulating tumor DNA (ctDNA), liquid biopsy technologies, tumor heterogeneity, mutational dynamics, and next-generation sequencing (NGS) methodologies
Cooperation and dissemination
I collaborate closely with clinical departments, national cancer centers, and international academic institutions across Denmark, Europe, and the USA. Ongoing consortia include a multicenter Phase III trials TOMBOLA) and translational research networks integrating ctDNA, immunotherapy, and genomics. I also contribute to academic–industry partnerships and cross-disciplinary initiatives focused on precision oncology and biomarker development.
Teaching
I regularly teach and supervise Master's and PhD students in molecular biology and ctDNA analysis. This includes hands-on instruction in NGS methods, data interpretation, and experimental design. I have taught international PhD courses at Aarhus University and mentored early-career researchers on translational cancer projects.
Keywords
- Cancer
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Collaborations and top research areas from the last five years
Projects
- 4 Active
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The urinary microbiome
Birkenkamp-Demtröder, K. (PI), Rasmussen, J. (Participant), Nordentoft, I. K. (Participant) & Dyrskjøt, L. (PI)
01/09/2022 → …
Project: Research
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TOMBOLA: Treatment Of Metastatic Bladder cancer at the time Of biochemical reLApse following radical cystectomy
Birkenkamp-Demtröder, K. (PI), Nordentoft, I. K. (Collaborator), Agerbæk, M. (PI), Jensen, J. B. (PI) & Dyrskjøt, L. (PI)
01/04/2020 → …
Project: Research
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Analyse af personlige genomiske rearrangementer (PAGER) til kontrol af patienter med blærekræft
Birkenkamp-Demtröder, K. (Participant), Dyrskjøt, L. (Participant), Nordentoft, I. K. (Participant), Jensen, J. B. (Participant), Agerbæk, M. (Participant) & Ørntoft, T. F. (Participant)
02/01/2013 → …
Project: Research
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Molekylære forandringer i klinisk blærekræft
Birkenkamp-Demtröder, K. (Participant), Nordentoft, I. K. (Participant), Dyrskjøt, L. (Participant) & Ørntoft, T. F. (Participant)
01/01/2011 → …
Project: Research
Research output
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Blood-Based Biomarkers for Bladder Cancer Diagnosis and Prognosis
Birkenkamp-Demtröder, K., Nordentoft, I., Strandgaard, T., Lindskrog, S. V. & Dyrskjøt, L., Jan 2025, Biology of Bladder Cancer: From Molecular Insights to Clinical Strategies. Knowles, M. A. & Dyrskjøt, L. (eds.). Springer, p. 393-413 21 p.Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
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Circulating tumour DNA and circulating tumour cells in bladder cancer — from discovery to clinical implementation
Lindskrog, S. V., Strandgaard, T., Nordentoft, I., Galsky, M. D., Powles, T., Agerbæk, M., Jensen, J. B., Alix-Panabières, C. & Dyrskjøt, L., 2025, (E-pub / Early view) In: Nature Reviews Urology. 5068.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
1 Citation (Scopus) -
Comprehensive genomic characterization of early-stage bladder cancer
Prip, F., Lamy, P., Lindskrog, S. V., Strandgaard, T., Nordentoft, I., Birkenkamp-Demtröder, K., Birkbak, N. J., Kristjánsdóttir, N., Kjær, A., Andreasen, T. G., Ahrenfeldt, J., Pedersen, J. S., Rasmussen, A. M., Hermann, G. G., Mogensen, K., Petersen, A. C., Hartmann, A., Grimm, M. O., Horstmann, M. & Nawroth, R. & 12 others, , Jan 2025, In: Nature Genetics. 57, 1, p. 115-125 11 p., 2301.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
Low T cell diversity associates with poor outcome in bladder cancer: A comprehensive longitudinal analysis of the T cell receptor repertoire
Kjær, A., Kristjánsdóttir, N., Juul, R. I., Nordentoft, I., Birkenkamp-Demtröder, K., Ahrenfeldt, J., Strandgaard, T., Radif, D., Hodgson, D., Abbosh, C., Aerts, H. J. W. L., Agerbæk, M., Jensen, J. B., Birkbak, N. J. & Dyrskjøt, L., 20 May 2025, In: Cell Reports Medicine. 6, 5, 102101.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Molecular Subtypes of Non-Muscle-Invasive Bladder Cancer
Prip, F., Lindskrog, S. V., Lamy, P., Strandgaard, T., Nordentoft, I., Birkenkamp-Demtröder, K. & Dyrskjøt, L., Jan 2025, Biology of Bladder Cancer: From Molecular Insights to Clinical Strategies. Knowles, M. A. & Dyrskjøt, L. (eds.). Springer Nature, p. 263-277 15 p.Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
Activities
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Member of the American Association for Cancer Research
Nordentoft, I. K. (Member)
1 Dec 2013Activity: Presentations, memberships, employment, ownership and other activities › Member of research network
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Advanced Sciclone NGS Training
Nordentoft, I. K. (Participant)
12 Nov 2013 → 14 Nov 2013Activity: Participating in or organising an event types › Participation in or organisation of workshop, seminar or course
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Cancer Genomics Conference
Nordentoft, I. K. (Participant)
3 Nov 2013 → 5 Nov 2013Activity: Participating in or organising an event types › Participation in or organisation of workshop, seminar or course
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Next Generation Sequencing Analysis
Nordentoft, I. K. (Participant)
27 May 2013 → 31 May 2013Activity: Participating in or organising an event types › Participation in or organisation of workshop, seminar or course
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Integrative Digital PCR
Nordentoft, I. K. (Participant)
11 Apr 2013 → 12 Apr 2013Activity: Participating in or organising an event types › Participation in or organisation of workshop, seminar or course