Projects per year
Personal profile
Research
My research focuses on bladder cancer genomics, tumor evolution, and ctDNA-based monitoring of minimal residual disease and treatment response. I specialize in exome, whole-genome, and targeted sequencing of cfDNA and tissue, applied in both prospective trials and retrospective cohort studies. My research has contributed to key discoveries in bladder cancer subtypes, ctDNA detection, mutational signatures, and TCR repertoire profiling.
Profile
Translational cancer researcher specializing in bladder cancer, with expertise in circulating tumor DNA (ctDNA), liquid biopsy technologies, tumor heterogeneity, mutational dynamics, and next-generation sequencing (NGS) methodologies
Cooperation and dissemination
I collaborate closely with clinical departments, national cancer centers, and international academic institutions across Denmark, Europe, and the USA. Ongoing consortia include a multicenter Phase III trials TOMBOLA) and translational research networks integrating ctDNA, immunotherapy, and genomics. I also contribute to academic–industry partnerships and cross-disciplinary initiatives focused on precision oncology and biomarker development.
Teaching
I regularly teach and supervise Master's and PhD students in molecular biology and ctDNA analysis. This includes hands-on instruction in NGS methods, data interpretation, and experimental design. I have taught international PhD courses at Aarhus University and mentored early-career researchers on translational cancer projects.
Keywords
- Cancer
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Projects
- 4 Active
-
The urinary microbiome
Birkenkamp-Demtröder, K. (PI), Rasmussen, J. (Participant), Nordentoft, I. K. (Participant) & Dyrskjøt, L. (PI)
01/09/2022 → …
Project: Research
-
TOMBOLA: Treatment Of Metastatic Bladder cancer at the time Of biochemical reLApse following radical cystectomy
Birkenkamp-Demtröder, K. (PI), Nordentoft, I. K. (Collaborator), Agerbæk, M. (PI), Jensen, J. B. (PI) & Dyrskjøt, L. (PI)
01/04/2020 → …
Project: Research
-
Analyse af personlige genomiske rearrangementer (PAGER) til kontrol af patienter med blærekræft
Birkenkamp-Demtröder, K. (Participant), Dyrskjøt, L. (Participant), Nordentoft, I. K. (Participant), Jensen, J. B. (Participant), Agerbæk, M. (Participant) & Ørntoft, T. F. (Participant)
02/01/2013 → …
Project: Research
-
Molekylære forandringer i klinisk blærekræft
Birkenkamp-Demtröder, K. (Participant), Nordentoft, I. K. (Participant), Dyrskjøt, L. (Participant) & Ørntoft, T. F. (Participant)
01/01/2011 → …
Project: Research
Research output
-
Circulating tumour DNA and circulating tumour cells in bladder cancer — from discovery to clinical implementation
Lindskrog, S. V., Strandgaard, T., Nordentoft, I., Galsky, M. D., Powles, T., Agerbæk, M., Jensen, J. B., Alix-Panabières, C. & Dyrskjøt, L., 2025, (E-pub / Early view) In: Nature Reviews Urology. 5068.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
-
Comprehensive genomic characterization of early-stage bladder cancer
Prip, F., Lamy, P., Lindskrog, S. V., Strandgaard, T., Nordentoft, I., Birkenkamp-Demtröder, K., Birkbak, N. J., Kristjánsdóttir, N., Kjær, A., Andreasen, T. G., Ahrenfeldt, J., Pedersen, J. S., Rasmussen, A. M., Hermann, G. G., Mogensen, K., Petersen, A. C., Hartmann, A., Grimm, M. O., Horstmann, M. & Nawroth, R. & 12 others, , Jan 2025, In: Nature Genetics. 57, 1, p. 115-125 11 p., 2301.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access1 Citation (Scopus) -
Beyond basics: Key mutation selection features for successful tumor-informed ctDNA detection
Nesic, M., Rasmussen, M. H., Henriksen, T. V., Demuth, C., Frydendahl, A., Nordentoft, I., Dyrskjøt, L. & Andersen, C. L., Sept 2024, In: International Journal of Cancer. 155, 5, p. 925-933 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access4 Citations (Scopus) -
Detection of circulating tumor DNA by tumor-informed whole-genome sequencing enables prediction of recurrence in stage III colorectal cancer patients
Frydendahl, A., Nors, J., Rasmussen, M. H., Henriksen, T. V., Nesic, M., Reinert, T., Afterman, D., Lauterman, T., Kuzman, M., Gonzalez, S., Glavas, D., Smadback, J., Maloney, D., Levativ, J., Yahalom, M., Ptashkin, R., Tavassoly, I., Donenhirsh, Z., White, E. & Kandasamy, R. & 13 others, , Nov 2024, In: European Journal of Cancer. 211, 114314.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
Field Cancerization Is Associated with Tumor Development, T-cell Exhaustion, and Clinical Outcomes in Bladder Cancer
Strandgaard, T., Nordentoft, I., Birkenkamp-Demtröder, K., Salminen, L., Prip, F., Rasmussen, J., Andreasen, T. G., Lindskrog, S. V., Christensen, E., Lamy, P., Knudsen, M., Steiniche, T., Jensen, J. B. & Dyrskjøt, L., Jan 2024, In: European Urology. 85, 1, p. 82-92 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile19 Citations (Scopus)66 Downloads (Pure)
Activities
-
Member of the American Association for Cancer Research
Nordentoft, I. K. (Member)
1 Dec 2013Activity: Presentations, memberships, employment, ownership and other activities › Member of research network
-
Advanced Sciclone NGS Training
Nordentoft, I. K. (Participant)
12 Nov 2013 → 14 Nov 2013Activity: Participating in or organising an event types › Participation in or organisation of workshop, seminar or course
-
Cancer Genomics Conference
Nordentoft, I. K. (Participant)
3 Nov 2013 → 5 Nov 2013Activity: Participating in or organising an event types › Participation in or organisation of workshop, seminar or course
-
Next Generation Sequencing Analysis
Nordentoft, I. K. (Participant)
27 May 2013 → 31 May 2013Activity: Participating in or organising an event types › Participation in or organisation of workshop, seminar or course
-
Integrative Digital PCR
Nordentoft, I. K. (Participant)
11 Apr 2013 → 12 Apr 2013Activity: Participating in or organising an event types › Participation in or organisation of workshop, seminar or course