Iver Kristiansen Nordentoft

Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Kevin Litchfield, The Francis Crick Institute
  • ,
  • Stacey Stanislaw, Roche Tissue Diagnostics
  • ,
  • Lavinia Spain, The Francis Crick Institute, Royal Marsden Hospital, London
  • ,
  • Lisa L. Gallegos, Roche Tissue Diagnostics
  • ,
  • Andrew Rowan, The Francis Crick Institute
  • ,
  • Desiree Schnidrig, The Francis Crick Institute
  • ,
  • Heidi Rosenbaum, Roche Sequencing Solutions
  • ,
  • Alexandre Harle, The Francis Crick Institute, Universite de Lorraine
  • ,
  • Lewis Au, The Francis Crick Institute, Royal Marsden Hospital, London
  • ,
  • Samantha M. Hill, Roche Tissue Diagnostics, University of Arizona
  • ,
  • Zayd Tippu, Royal Marsden Hospital, London
  • ,
  • Jennifer Thomas, Royal Marsden Hospital, London
  • ,
  • Lisa Thompson, Royal Marsden Hospital, London
  • ,
  • Hang Xu, The Francis Crick Institute
  • ,
  • Stuart Horswell, The Francis Crick Institute
  • ,
  • Aoune Barhoumi, Roche Tissue Diagnostics
  • ,
  • Carol Jones, Roche Tissue Diagnostics
  • ,
  • Katherine F. Leith, Roche Tissue Diagnostics
  • ,
  • Daniel L. Burgess, Roche Sequencing Solutions
  • ,
  • Thomas B.K. Watkins, The Francis Crick Institute
  • ,
  • Emilia Lim, The Francis Crick Institute
  • ,
  • Nicolai J. Birkbak
  • Philippe Lamy
  • ,
  • Iver Nordentoft
  • Lars Dyrskjøt
  • Lisa Pickering, Royal Marsden Hospital, London
  • ,
  • Stephen Hazell, Royal Marsden NHS Foundation Trust
  • ,
  • Mariam Jamal-Hanjani, University College London
  • ,
  • PEACE Consortium
  • ,
  • James Larkin, Denmark
  • Charles Swanton, The Francis Crick Institute, Unknown
  • Nelson Alexander
  • ,
  • Samra Turajlic

Solid tumors are under-sampled in the clinic, such that only 0.0005% of initial tumor volume is used as input for diagnostic testing. Litchfield et al. apply the principles of representative sampling to implement an unbiased tumor sampling approach that improves the reproducibility and accuracy of next-generation sequencing.

Original languageEnglish
Article number107550
JournalCell Reports
Volume31
Issue5
ISSN2211-1247
DOIs
Publication statusPublished - May 2020

    Research areas

  • biomarkers, homogenization, molecular profiling, representative sampling, tumor hetereogeneity, tumor mutational burden, tumor sampling, tumor sequencing

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