Iver Kristiansen Nordentoft

miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer

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MicroRNA is a naturally occurring class of non-coding RNA molecules that mediate posttranscriptional gene regulation and are strongly implicated in cellular processes such as cell proliferation, carcinogenesis, cell survival and apoptosis. Consequently there is increasing focus on miRNA expression as prognostic factors for outcome and chemotherapy response. Only approximately 50% of patients with bladder cancer respond to chemotherapy. Therefore, predictive markers, such as miRNAs, that can identify subgroups of patients who will benefit from chemotherapy will have great value for treatment guidance.
Original languageEnglish
JournalB M C Medical Genomics
Pages (from-to)40
Publication statusPublished - 2012

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